Distinct roles for phosphoinositide 3-kinase, mitogen-activated protein kinase and p38 MAPK in mediating cell cycle progression of breast cancer cells

Addition of the ErbB-ligand, Heregulinbeta1 (HRG), to breast tumour-derived T47D cells promotes D-cyclin expression, p21(cip1) synthesis, cyclin-dependent kinase (CDK) activation through re-distribution of p27(kip1) and DNA synthesis. In contrast EGF has no effect on T47D cell cycle progression. By...

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Veröffentlicht in:	Oncogene 2002-07, Vol.21 (29), p.4567-4576
Hauptverfasser:	NEVE, Richard M, HOLBRO, Thomas, HYNES, Nancy E
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Biological and medical sciences Blotting, Western Breast cancer Breast Neoplasms - enzymology Breast Neoplasms - pathology Cancer cells Cell cycle Cell Cycle - drug effects Cell Cycle Proteins - metabolism Cell Division - drug effects Cell growth Cell physiology Cell proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin-dependent kinase Cyclin-dependent kinase inhibitor p21 Cyclin-dependent kinase inhibitor p27 Cyclin-dependent kinases Cyclins - metabolism Development and progression DNA biosynthesis Enzyme Inhibitors - pharmacology Epidermal growth factor Epidermal Growth Factor - pharmacology ErbB protein ErbB-2 protein Flow Cytometry Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans Kinases Ligands Mammary gland diseases MAP kinase Medical sciences Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Molecular modelling Neuregulin-1 - pharmacology p38 Mitogen-Activated Protein Kinases Peptides Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Physiological aspects Protein kinase Protein kinases Proteins Signal Transduction - drug effects Therapeutic targets Time Factors Tumor Cells, Cultured Tumors
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