Transcriptional targeting of conditionally replicating adenovirus to dividing endothelial cells

Conditionally replicating adenoviruses (CRADs) are a novel strategy in cancer treatment and clinical trials using CRADs targeted to tumor cells have been reported recently. We hypothesized that it would be possible to construct CRADs targeted to dividing endothelial cells, which are present in the t...

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Veröffentlicht in:	Gene therapy 2002-07, Vol.9 (14), p.972-979
Hauptverfasser:	SAVONTAUS, M. T, SAUTER, B. V, HUANG, T-G, WOO, S. L. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - physiology Adenoviruses Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Angiogenesis Antigens, CD Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Capillaries Cell Division Cell Line Clinical trials Cytotoxicity E1A protein E1B gene Endoglin Endothelial cells Endothelium Endothelium, Vascular - cytology Fundamental and applied biological sciences. Psychology Gene therapy Genes, Regulator Genetic Engineering Genetic Therapy - methods Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Medical sciences Neoplasms - blood supply Neoplasms - genetics Neoplasms - therapy Neovascularization, Pathologic Plaque assay Receptor Protein-Tyrosine Kinases - genetics Receptors, Cell Surface Receptors, Growth Factor - genetics Receptors, Vascular Endothelial Growth Factor Regulatory sequences Reverse Transcriptase Polymerase Chain Reaction Transcription Transfection - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor cells Umbilical vein Vascular Cell Adhesion Molecule-1 - genetics Vascular endothelial growth factor receptor 2 Virus Replication
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