Cytomegalovirus (CMV) retinitis immune restoration disease occurs during highly active antiretroviral therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environment
Plasma levels of cytomegalovirus (CMV)-specific immunoglobulin G (IgG), soluble (s) CD30, sCD26 (dipeptidyl peptidase IV [DPP IV]) enzyme activity, and tumor necrosis factor receptor-I (TNFR-I) were assessed in human immunodeficiency virus (HIV)-infected patients who experienced CMV retinitis (CMVR)...
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| Veröffentlicht in: | The Journal of infectious diseases 2002-06, Vol.185 (12), p.1813-1817 |
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| container_title | The Journal of infectious diseases |
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| creator | Stone, Shelley F. Price, Patricia Tay-Kearney, Mei-Ling French, Martyn A. |
| description | Plasma levels of cytomegalovirus (CMV)-specific immunoglobulin G (IgG), soluble (s) CD30, sCD26 (dipeptidyl peptidase IV [DPP IV]) enzyme activity, and tumor necrosis factor receptor-I (TNFR-I) were assessed in human immunodeficiency virus (HIV)-infected patients who experienced CMV retinitis (CMVR) as an immune restoration disease (IRD) during their first 6 months of highly active antiretroviral therapy (HAART) and in CMV-seropositive, HIV-infected patients with similar baseline CD4+ T cell counts who had uneventful immune reconstitution. Patients who experienced CMVR IRD had a significant increase in CMV-specific IgG during their first 12 months of HAART, indicating restored CMV-specific immune responses. They also had significantly higher levels of sCD30 both before HAART and for up to 12 months after start of treatment. sCD30 levels remained elevated during 48 months of HAART, suggesting persistence of a predominant Th2 cytokine environment. Levels of sCD26 (DPP IV) enzyme activity and TNFR-I did not differ significantly between the 2 groups at any time point. |
| doi_str_mv | 10.1086/340636 |
| format | Article |
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Patients who experienced CMVR IRD had a significant increase in CMV-specific IgG during their first 12 months of HAART, indicating restored CMV-specific immune responses. They also had significantly higher levels of sCD30 both before HAART and for up to 12 months after start of treatment. sCD30 levels remained elevated during 48 months of HAART, suggesting persistence of a predominant Th2 cytokine environment. Levels of sCD26 (DPP IV) enzyme activity and TNFR-I did not differ significantly between the 2 groups at any time point.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/340636</identifier><identifier>PMID: 12085331</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; AIDS ; Antigens, CD - analysis ; Antiretroviral Therapy, Highly Active ; Antiretrovirals ; Biological and medical sciences ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; Concise Comunications ; Cytokines ; Cytomegalovirus ; Cytomegalovirus infections ; Cytomegalovirus Retinitis - complications ; Cytomegalovirus Retinitis - immunology ; Dipeptidyl Peptidase 4 - analysis ; Enzyme activity ; Female ; Highly active antiretroviral therapy ; HIV ; HIV Infections - complications ; HIV Infections - drug therapy ; Human viral diseases ; Humans ; Immunoglobulin G - analysis ; Infectious diseases ; Ki-1 Antigen - analysis ; Longitudinal Studies ; Male ; Medical sciences ; Receptors, Tumor Necrosis Factor - analysis ; Receptors, Tumor Necrosis Factor, Type I ; Recurrence ; Retinitis ; Retrospective Studies ; T lymphocytes ; Th2 Cells - immunology ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>The Journal of infectious diseases, 2002-06, Vol.185 (12), p.1813-1817</ispartof><rights>Copyright 2002 Infectious Diseases Society of America</rights><rights>2002 by the Infectious Diseases Society of America 2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jun 15 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-63d925394166e2717f0280e08e0bf88e4db8d9c6c095e559ed9a519a9b7344243</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30138191$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30138191$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13738319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12085331$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stone, Shelley F.</creatorcontrib><creatorcontrib>Price, Patricia</creatorcontrib><creatorcontrib>Tay-Kearney, Mei-Ling</creatorcontrib><creatorcontrib>French, Martyn A.</creatorcontrib><title>Cytomegalovirus (CMV) retinitis immune restoration disease occurs during highly active antiretroviral therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environment</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Plasma levels of cytomegalovirus (CMV)-specific immunoglobulin G (IgG), soluble (s) CD30, sCD26 (dipeptidyl peptidase IV [DPP IV]) enzyme activity, and tumor necrosis factor receptor-I (TNFR-I) were assessed in human immunodeficiency virus (HIV)-infected patients who experienced CMV retinitis (CMVR) as an immune restoration disease (IRD) during their first 6 months of highly active antiretroviral therapy (HAART) and in CMV-seropositive, HIV-infected patients with similar baseline CD4+ T cell counts who had uneventful immune reconstitution. Patients who experienced CMVR IRD had a significant increase in CMV-specific IgG during their first 12 months of HAART, indicating restored CMV-specific immune responses. They also had significantly higher levels of sCD30 both before HAART and for up to 12 months after start of treatment. sCD30 levels remained elevated during 48 months of HAART, suggesting persistence of a predominant Th2 cytokine environment. Levels of sCD26 (DPP IV) enzyme activity and TNFR-I did not differ significantly between the 2 groups at any time point.</description><subject>Adult</subject><subject>AIDS</subject><subject>Antigens, CD - analysis</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Antiretrovirals</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-CD8 Ratio</subject><subject>Concise Comunications</subject><subject>Cytokines</subject><subject>Cytomegalovirus</subject><subject>Cytomegalovirus infections</subject><subject>Cytomegalovirus Retinitis - complications</subject><subject>Cytomegalovirus Retinitis - immunology</subject><subject>Dipeptidyl Peptidase 4 - analysis</subject><subject>Enzyme activity</subject><subject>Female</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - drug therapy</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Infectious diseases</subject><subject>Ki-1 Antigen - analysis</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Receptors, Tumor Necrosis Factor - analysis</subject><subject>Receptors, Tumor Necrosis Factor, Type I</subject><subject>Recurrence</subject><subject>Retinitis</subject><subject>Retrospective Studies</subject><subject>T lymphocytes</subject><subject>Th2 Cells - immunology</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQhyMEokuBNwAZJBAcAv4Xxz6iFVBEKQcKqnqJvM5k19vEDrZT2LfkkfBqV21BQpwszXz6fR7NFMVDgl8RLMVrxrFg4lYxIxWrSyEIu13MMKa0JFKpg-JejGuMMWeivlscEIplxRiZFb_mm-QHWOreX9owRfRi_unbSxQgWWeTjcgOw-QgF2LyQSfrHWptBB0BeWOmEFE7BeuWaGWXq36DtEn2EpB2yeaQsE3VPUorCHrclNa1k4H2jzjfoews4wjGdtbcMI7eRYjoh00r65BGY4DWD9blcHS6osjkv1_YzILLGu8GcOl-cafTfYQH-_ew-Pru7en8qDz-_P7D_M1xabgkqRSsVbRiihMhgNak7jCVGLAEvOikBN4uZKuMMFhVUFUKWqUrorRa1Ixzytlh8XyXOwb_fcrjNIONBvpeO_BTbGoiq5oI-V-QSC4I4SKDT_8C134KLg_RUMoUpkTc0JrgYwzQNWOwgw6bhuBmewnN7hIy-HifNi0GaK-x_eoz8GwP6Gh03wXtjI3XHKuZZERl7smO89P4b9mjHbPervWKYpgwSdTWVe76Nib4edXX4aIRNaur5ujsvPl4fsLPvpzQhrHfLkXhwQ</recordid><startdate>20020615</startdate><enddate>20020615</enddate><creator>Stone, Shelley F.</creator><creator>Price, Patricia</creator><creator>Tay-Kearney, Mei-Ling</creator><creator>French, Martyn A.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020615</creationdate><title>Cytomegalovirus (CMV) retinitis immune restoration disease occurs during highly active antiretroviral therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environment</title><author>Stone, Shelley F. ; Price, Patricia ; Tay-Kearney, Mei-Ling ; French, Martyn A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-63d925394166e2717f0280e08e0bf88e4db8d9c6c095e559ed9a519a9b7344243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>AIDS</topic><topic>Antigens, CD - analysis</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Antiretrovirals</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4-CD8 Ratio</topic><topic>Concise Comunications</topic><topic>Cytokines</topic><topic>Cytomegalovirus</topic><topic>Cytomegalovirus infections</topic><topic>Cytomegalovirus Retinitis - complications</topic><topic>Cytomegalovirus Retinitis - immunology</topic><topic>Dipeptidyl Peptidase 4 - analysis</topic><topic>Enzyme activity</topic><topic>Female</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - drug therapy</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Infectious diseases</topic><topic>Ki-1 Antigen - analysis</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Receptors, Tumor Necrosis Factor - analysis</topic><topic>Receptors, Tumor Necrosis Factor, Type I</topic><topic>Recurrence</topic><topic>Retinitis</topic><topic>Retrospective Studies</topic><topic>T lymphocytes</topic><topic>Th2 Cells - immunology</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stone, Shelley F.</creatorcontrib><creatorcontrib>Price, Patricia</creatorcontrib><creatorcontrib>Tay-Kearney, Mei-Ling</creatorcontrib><creatorcontrib>French, Martyn A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stone, Shelley F.</au><au>Price, Patricia</au><au>Tay-Kearney, Mei-Ling</au><au>French, Martyn A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytomegalovirus (CMV) retinitis immune restoration disease occurs during highly active antiretroviral therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environment</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2002-06-15</date><risdate>2002</risdate><volume>185</volume><issue>12</issue><spage>1813</spage><epage>1817</epage><pages>1813-1817</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Plasma levels of cytomegalovirus (CMV)-specific immunoglobulin G (IgG), soluble (s) CD30, sCD26 (dipeptidyl peptidase IV [DPP IV]) enzyme activity, and tumor necrosis factor receptor-I (TNFR-I) were assessed in human immunodeficiency virus (HIV)-infected patients who experienced CMV retinitis (CMVR) as an immune restoration disease (IRD) during their first 6 months of highly active antiretroviral therapy (HAART) and in CMV-seropositive, HIV-infected patients with similar baseline CD4+ T cell counts who had uneventful immune reconstitution. Patients who experienced CMVR IRD had a significant increase in CMV-specific IgG during their first 12 months of HAART, indicating restored CMV-specific immune responses. They also had significantly higher levels of sCD30 both before HAART and for up to 12 months after start of treatment. sCD30 levels remained elevated during 48 months of HAART, suggesting persistence of a predominant Th2 cytokine environment. Levels of sCD26 (DPP IV) enzyme activity and TNFR-I did not differ significantly between the 2 groups at any time point.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>12085331</pmid><doi>10.1086/340636</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 2002-06, Vol.185 (12), p.1813-1817 |
| issn | 0022-1899 1537-6613 |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult AIDS Antigens, CD - analysis Antiretroviral Therapy, Highly Active Antiretrovirals Biological and medical sciences CD4 Lymphocyte Count CD4-CD8 Ratio Concise Comunications Cytokines Cytomegalovirus Cytomegalovirus infections Cytomegalovirus Retinitis - complications Cytomegalovirus Retinitis - immunology Dipeptidyl Peptidase 4 - analysis Enzyme activity Female Highly active antiretroviral therapy HIV HIV Infections - complications HIV Infections - drug therapy Human viral diseases Humans Immunoglobulin G - analysis Infectious diseases Ki-1 Antigen - analysis Longitudinal Studies Male Medical sciences Receptors, Tumor Necrosis Factor - analysis Receptors, Tumor Necrosis Factor, Type I Recurrence Retinitis Retrospective Studies T lymphocytes Th2 Cells - immunology Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Cytomegalovirus (CMV) retinitis immune restoration disease occurs during highly active antiretroviral therapy-induced restoration of CMV-specific immune responses within a predominant Th2 cytokine environment |
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