Myocardial viability evaluation using magnetocardiography in patients with coronary artery disease
OBJECTIVEMagnetocardiography (MCG) has been used to risk stratify patients in terms of sudden death or to detect ischemia. We evaluated the potential of this technique to assess myocardial viability in coronary artery disease. METHODSFifteen patients aged 36–75 (median, 59) years with stable single-...
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| Veröffentlicht in: | Coronary artery disease 2004-05, Vol.15 (3), p.155-162 |
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| creator | Morguet, Andreas J Behrens, Steffen Kosch, Olaf Lange, Christine Zabel, Markus Selbig, Daniela Munz, Dieter L Schultheiss, Heinz-Peter Koch, Hans |
| description | OBJECTIVEMagnetocardiography (MCG) has been used to risk stratify patients in terms of sudden death or to detect ischemia. We evaluated the potential of this technique to assess myocardial viability in coronary artery disease.
METHODSFifteen patients aged 36–75 (median, 59) years with stable single-vessel disease (≥70% diameter stenosis) and corresponding regional wall-motion abnormality underwent (1) echocardiography to evaluate wall motion, (2) Tl dipyridamole single-photon emission computed tomography to document perfusion and (3) quantitative F-fluorodeoxyglucose positron emission tomography to assess viability in 16 left-ventricular wall segments. MCG was performed in each patient using a shielded prototype 49-channel low-temperature superconducting quantum interference device (SQUID) system. Multiple time and area parameters were extracted automatically from each baseline-corrected data set.
RESULTSEleven patients had prior myocardial infarction. In each patient, four to 12 (median, seven) segments were lesion dependent, totalling up to 117 out of 240 segments. A total of 88 segments (75%) were viable and 29 segments (25%) represented scar. Patients were divided into three categories(a) no scar segments (five patients), (b) scar in one to three segments (six patients) and (c) scar in ≥ four segments (four patients). The three MCG parameters with the best selectivity were identified using linear discriminant analysis with forward inclusion (P |
| doi_str_mv | 10.1097/00019501-200405000-00004 |
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METHODSFifteen patients aged 36–75 (median, 59) years with stable single-vessel disease (≥70% diameter stenosis) and corresponding regional wall-motion abnormality underwent (1) echocardiography to evaluate wall motion, (2) Tl dipyridamole single-photon emission computed tomography to document perfusion and (3) quantitative F-fluorodeoxyglucose positron emission tomography to assess viability in 16 left-ventricular wall segments. MCG was performed in each patient using a shielded prototype 49-channel low-temperature superconducting quantum interference device (SQUID) system. Multiple time and area parameters were extracted automatically from each baseline-corrected data set.
RESULTSEleven patients had prior myocardial infarction. In each patient, four to 12 (median, seven) segments were lesion dependent, totalling up to 117 out of 240 segments. A total of 88 segments (75%) were viable and 29 segments (25%) represented scar. Patients were divided into three categories(a) no scar segments (five patients), (b) scar in one to three segments (six patients) and (c) scar in ≥ four segments (four patients). The three MCG parameters with the best selectivity were identified using linear discriminant analysis with forward inclusion (P<0.10). The corresponding Fisherʼs discriminant functions classified all patients correctly (Wilksʼ λ=0.079).
CONCLUSIONSelected MCG parameters yielded accurate patient classification with regard to the extension of myocardial scar within the viable tissue in retrospect. These findings indicate that MCG may contribute to the assessment of myocardial viability. Further evaluation in a comprehensive multicenter study is warranted.</description><identifier>ISSN: 0954-6928</identifier><identifier>EISSN: 1473-5830</identifier><identifier>DOI: 10.1097/00019501-200405000-00004</identifier><identifier>PMID: 15096996</identifier><language>eng</language><publisher>England: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Aged ; Cicatrix - diagnosis ; Cicatrix - pathology ; Coronary Angiography ; Coronary Disease - diagnosis ; Coronary Disease - physiopathology ; Diagnosis, Differential ; Discriminant Analysis ; Electrocardiography ; Female ; Fluorodeoxyglucose F18 ; Humans ; Magnetics - instrumentation ; Male ; Middle Aged ; Myocardium - pathology ; Risk Factors ; Signal Processing, Computer-Assisted - instrumentation ; Thallium ; Tissue Survival ; Tomography, Emission-Computed</subject><ispartof>Coronary artery disease, 2004-05, Vol.15 (3), p.155-162</ispartof><rights>2004 Lippincott Williams & Wilkins, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3854-14d3acd6c6a1df7204f40e339b83e1a283278a1a6bb21c1050ce1e4f357ce0203</citedby><cites>FETCH-LOGICAL-c3854-14d3acd6c6a1df7204f40e339b83e1a283278a1a6bb21c1050ce1e4f357ce0203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15096996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morguet, Andreas J</creatorcontrib><creatorcontrib>Behrens, Steffen</creatorcontrib><creatorcontrib>Kosch, Olaf</creatorcontrib><creatorcontrib>Lange, Christine</creatorcontrib><creatorcontrib>Zabel, Markus</creatorcontrib><creatorcontrib>Selbig, Daniela</creatorcontrib><creatorcontrib>Munz, Dieter L</creatorcontrib><creatorcontrib>Schultheiss, Heinz-Peter</creatorcontrib><creatorcontrib>Koch, Hans</creatorcontrib><title>Myocardial viability evaluation using magnetocardiography in patients with coronary artery disease</title><title>Coronary artery disease</title><addtitle>Coron Artery Dis</addtitle><description>OBJECTIVEMagnetocardiography (MCG) has been used to risk stratify patients in terms of sudden death or to detect ischemia. We evaluated the potential of this technique to assess myocardial viability in coronary artery disease.
METHODSFifteen patients aged 36–75 (median, 59) years with stable single-vessel disease (≥70% diameter stenosis) and corresponding regional wall-motion abnormality underwent (1) echocardiography to evaluate wall motion, (2) Tl dipyridamole single-photon emission computed tomography to document perfusion and (3) quantitative F-fluorodeoxyglucose positron emission tomography to assess viability in 16 left-ventricular wall segments. MCG was performed in each patient using a shielded prototype 49-channel low-temperature superconducting quantum interference device (SQUID) system. Multiple time and area parameters were extracted automatically from each baseline-corrected data set.
RESULTSEleven patients had prior myocardial infarction. In each patient, four to 12 (median, seven) segments were lesion dependent, totalling up to 117 out of 240 segments. A total of 88 segments (75%) were viable and 29 segments (25%) represented scar. Patients were divided into three categories(a) no scar segments (five patients), (b) scar in one to three segments (six patients) and (c) scar in ≥ four segments (four patients). The three MCG parameters with the best selectivity were identified using linear discriminant analysis with forward inclusion (P<0.10). The corresponding Fisherʼs discriminant functions classified all patients correctly (Wilksʼ λ=0.079).
CONCLUSIONSelected MCG parameters yielded accurate patient classification with regard to the extension of myocardial scar within the viable tissue in retrospect. These findings indicate that MCG may contribute to the assessment of myocardial viability. Further evaluation in a comprehensive multicenter study is warranted.</description><subject>Adult</subject><subject>Aged</subject><subject>Cicatrix - diagnosis</subject><subject>Cicatrix - pathology</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary Disease - physiopathology</subject><subject>Diagnosis, Differential</subject><subject>Discriminant Analysis</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Humans</subject><subject>Magnetics - instrumentation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardium - pathology</subject><subject>Risk Factors</subject><subject>Signal Processing, Computer-Assisted - instrumentation</subject><subject>Thallium</subject><subject>Tissue Survival</subject><subject>Tomography, Emission-Computed</subject><issn>0954-6928</issn><issn>1473-5830</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kcFu1DAQhq0K1G4Lr4B84pZ2HNuJc6wqaJGKuMDZmjiTXRdvvLWTrvbtMd0FThyskaXvt2e-YYwLuBbQtTcAIDoNoqoBFOhyrcoBdcZWQrWy0kbCG7aCTquq6WpzwS5zfiohpVt9zi6Ehq7pumbF-q-H6DANHgN_8dj74OcDpxcMC84-TnzJflrzLa4nmo9kXCfcbQ7cT3xXGJrmzPd-3nAXU5wwHTimmUoZfCbM9I69HTFken-qV-zH50_f7x6qx2_3X-5uHysnTelTqEGiGxrXoBjGtgY1KiApu95IElgbWbcGBTZ9XwsnytSOBKlR6tYR1CCv2Mfju7sUnxfKs9367CgEnCgu2bbC6Ma0TQHNEXQp5pxotLvkt6VxK8D-9mv_-LV__dpXvyX64fTH0m9p-Bc8CS2AOgL7GIqE_DMse0p2Qxjmjf3f3uQv0nSHUA</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Morguet, Andreas J</creator><creator>Behrens, Steffen</creator><creator>Kosch, Olaf</creator><creator>Lange, Christine</creator><creator>Zabel, Markus</creator><creator>Selbig, Daniela</creator><creator>Munz, Dieter L</creator><creator>Schultheiss, Heinz-Peter</creator><creator>Koch, Hans</creator><general>Lippincott Williams & Wilkins, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200405</creationdate><title>Myocardial viability evaluation using magnetocardiography in patients with coronary artery disease</title><author>Morguet, Andreas J ; Behrens, Steffen ; Kosch, Olaf ; Lange, Christine ; Zabel, Markus ; Selbig, Daniela ; Munz, Dieter L ; Schultheiss, Heinz-Peter ; Koch, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3854-14d3acd6c6a1df7204f40e339b83e1a283278a1a6bb21c1050ce1e4f357ce0203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cicatrix - diagnosis</topic><topic>Cicatrix - pathology</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - diagnosis</topic><topic>Coronary Disease - physiopathology</topic><topic>Diagnosis, Differential</topic><topic>Discriminant Analysis</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Humans</topic><topic>Magnetics - instrumentation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardium - pathology</topic><topic>Risk Factors</topic><topic>Signal Processing, Computer-Assisted - instrumentation</topic><topic>Thallium</topic><topic>Tissue Survival</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morguet, Andreas J</creatorcontrib><creatorcontrib>Behrens, Steffen</creatorcontrib><creatorcontrib>Kosch, Olaf</creatorcontrib><creatorcontrib>Lange, Christine</creatorcontrib><creatorcontrib>Zabel, Markus</creatorcontrib><creatorcontrib>Selbig, Daniela</creatorcontrib><creatorcontrib>Munz, Dieter L</creatorcontrib><creatorcontrib>Schultheiss, Heinz-Peter</creatorcontrib><creatorcontrib>Koch, Hans</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Coronary artery disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morguet, Andreas J</au><au>Behrens, Steffen</au><au>Kosch, Olaf</au><au>Lange, Christine</au><au>Zabel, Markus</au><au>Selbig, Daniela</au><au>Munz, Dieter L</au><au>Schultheiss, Heinz-Peter</au><au>Koch, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial viability evaluation using magnetocardiography in patients with coronary artery disease</atitle><jtitle>Coronary artery disease</jtitle><addtitle>Coron Artery Dis</addtitle><date>2004-05</date><risdate>2004</risdate><volume>15</volume><issue>3</issue><spage>155</spage><epage>162</epage><pages>155-162</pages><issn>0954-6928</issn><eissn>1473-5830</eissn><abstract>OBJECTIVEMagnetocardiography (MCG) has been used to risk stratify patients in terms of sudden death or to detect ischemia. We evaluated the potential of this technique to assess myocardial viability in coronary artery disease.
METHODSFifteen patients aged 36–75 (median, 59) years with stable single-vessel disease (≥70% diameter stenosis) and corresponding regional wall-motion abnormality underwent (1) echocardiography to evaluate wall motion, (2) Tl dipyridamole single-photon emission computed tomography to document perfusion and (3) quantitative F-fluorodeoxyglucose positron emission tomography to assess viability in 16 left-ventricular wall segments. MCG was performed in each patient using a shielded prototype 49-channel low-temperature superconducting quantum interference device (SQUID) system. Multiple time and area parameters were extracted automatically from each baseline-corrected data set.
RESULTSEleven patients had prior myocardial infarction. In each patient, four to 12 (median, seven) segments were lesion dependent, totalling up to 117 out of 240 segments. A total of 88 segments (75%) were viable and 29 segments (25%) represented scar. Patients were divided into three categories(a) no scar segments (five patients), (b) scar in one to three segments (six patients) and (c) scar in ≥ four segments (four patients). The three MCG parameters with the best selectivity were identified using linear discriminant analysis with forward inclusion (P<0.10). The corresponding Fisherʼs discriminant functions classified all patients correctly (Wilksʼ λ=0.079).
CONCLUSIONSelected MCG parameters yielded accurate patient classification with regard to the extension of myocardial scar within the viable tissue in retrospect. These findings indicate that MCG may contribute to the assessment of myocardial viability. Further evaluation in a comprehensive multicenter study is warranted.</abstract><cop>England</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>15096996</pmid><doi>10.1097/00019501-200405000-00004</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Cicatrix - diagnosis Cicatrix - pathology Coronary Angiography Coronary Disease - diagnosis Coronary Disease - physiopathology Diagnosis, Differential Discriminant Analysis Electrocardiography Female Fluorodeoxyglucose F18 Humans Magnetics - instrumentation Male Middle Aged Myocardium - pathology Risk Factors Signal Processing, Computer-Assisted - instrumentation Thallium Tissue Survival Tomography, Emission-Computed |
| title | Myocardial viability evaluation using magnetocardiography in patients with coronary artery disease |
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