Spinal Axon Regeneration Induced by Elevation of Cyclic AMP

Myelin inhibitors, including MAG, are major impediments to CNS regeneration. However, CNS axons of DRGs regenerate if the peripheral branch of these neurons is lesioned first. We show that 1 day post-peripheral-lesion, DRG-cAMP levels triple and MAG/myelin no longer inhibit growth, an effect that is...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2002-06, Vol.34 (6), p.895-903
Hauptverfasser:	Qiu, Jin, Cai, Dongming, Dai, Haining, McAtee, Marietta, Hoffman, Paul N., Bregman, Barbara S., Filbin, Marie T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - drug effects Axons - enzymology Axons - physiology Bucladesine - pharmacology Cyclic AMP - antagonists & inhibitors Cyclic AMP - biosynthesis Cyclic AMP - physiology Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors Cyclic AMP-Dependent Protein Kinases - metabolism Female Ganglia, Spinal - drug effects Ganglia, Spinal - physiology Kinases Medical research Nerve Regeneration - drug effects Nerve Regeneration - physiology Rats Rats, Sprague-Dawley Rodents Spinal cord
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!