Does the Addition of Information on Genotype Improve Prediction of the Risk of Melanoma and Nonmelanoma Skin Cancer beyond That Obtained from Skin Phenotype?

The authors quantified improvement in predicting cutaneous malignant melanoma, basal cell carcinoma, and squamous cell carcinoma of the skin made possible by information on common variants of the melanocortin-1 receptor gene (MC1R) in a 1998–1999 population-based case-control study of subjects aged...

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Veröffentlicht in:	American journal of epidemiology 2004-05, Vol.159 (9), p.826-833
Hauptverfasser:	Dwyer, Terence, Stankovich, James M., Blizzard, Leigh, FitzGerald, Liesel M., Dickinson, Joanne L., Reilly, Anne, Williamson, Jan, Ashbolt, Rosie, Berwick, Marianne, Sale, Michèle M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis. Health state Biological and medical sciences Carcinoma, Basal Cell - epidemiology Carcinoma, Basal Cell - genetics Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Case studies Case-Control Studies CMM cutaneous malignant melanoma Dermatology epidemiologic factors Epidemiology Female Gene Frequency General aspects Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Genetic Testing - methods Genetic Testing - standards Genetic Variation - genetics Genetics Genotype Humans Male MC1R Medical sciences melanins Melanins - analysis melanocortin melanocortin-1 receptor gene Melanoma - epidemiology Melanoma - genetics Middle Aged PCR polymerase chain reaction Polymorphism polymorphism (genetics) Population Surveillance - methods Predictive Value of Tests Public health. Hygiene Public health. Hygiene-occupational medicine receiver operating characteristic receptor Receptor, Melanocortin, Type 1 - genetics Registries Risk Assessment - methods Risk Factors ROC ROC Curve Skin - chemistry Skin cancer Skin Neoplasms - epidemiology Skin Neoplasms - genetics Spectrophotometry - methods Spectrophotometry - standards Tasmania - epidemiology Tumors of the skin and soft tissue. Premalignant lesions type 1
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