Endothelial function and mechanical properties of the common carotid artery in children on parenteral nutrition
Intravenous administration of nutrition mixtures induces endothelial damage and arterial wall remodeling in animal models. To study endothelial function and common carotid artery mechanical properties in children receiving parenteral nutrition, we used noninvasive ultrasonic measurements in 18 child...
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| Veröffentlicht in: | Pediatric research 2004-05, Vol.55 (5), p.789-793 |
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| container_title | Pediatric research |
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| creator | AGGOUN, Yacine COLOMB, Virginie TURANLAHTI, Maila CORRIOL, Odile GOULET, Olivier SIDI, Daniel RICOUR, Claude BONNET, Damien |
| description | Intravenous administration of nutrition mixtures induces endothelial damage and arterial wall remodeling in animal models. To study endothelial function and common carotid artery mechanical properties in children receiving parenteral nutrition, we used noninvasive ultrasonic measurements in 18 children on parenteral nutrition and 18 controls. No difference appeared in the geometry of the common carotid artery (intima media thickness, systolic and diastolic diameters) between the patients on parenteral nutrition and the controls. The incremental elastic modulus was significantly higher in the patients on parenteral nutrition (1.8 +/- 0.4 versus 1.4 +/- 0.5 4 mm Hg x 10(3), p < 0.05) reflecting alteration of the elastic properties of the arterial wall independent of the vessel geometry. The flow-mediated dilatation of the brachial artery was significantly lower in the patients on parenteral nutrition (6 +/- 3 versus 8 +/- 3%, p < 0.05), whereas the dilatation after glyceryl trinitrate administration was similar (22 +/- 9 versus 25 +/- 9%). Children on parenteral nutrition exhibit endothelial dysfunction and altered stiffness of the common carotid artery. The noninvasive methods used in this study may prove useful for objectively determining the effects of various preventive methods. |
| doi_str_mv | 10.1203/01.PDR.0000115680.46755.F5 |
| format | Article |
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To study endothelial function and common carotid artery mechanical properties in children receiving parenteral nutrition, we used noninvasive ultrasonic measurements in 18 children on parenteral nutrition and 18 controls. No difference appeared in the geometry of the common carotid artery (intima media thickness, systolic and diastolic diameters) between the patients on parenteral nutrition and the controls. The incremental elastic modulus was significantly higher in the patients on parenteral nutrition (1.8 +/- 0.4 versus 1.4 +/- 0.5 4 mm Hg x 10(3), p < 0.05) reflecting alteration of the elastic properties of the arterial wall independent of the vessel geometry. The flow-mediated dilatation of the brachial artery was significantly lower in the patients on parenteral nutrition (6 +/- 3 versus 8 +/- 3%, p < 0.05), whereas the dilatation after glyceryl trinitrate administration was similar (22 +/- 9 versus 25 +/- 9%). Children on parenteral nutrition exhibit endothelial dysfunction and altered stiffness of the common carotid artery. The noninvasive methods used in this study may prove useful for objectively determining the effects of various preventive methods.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/01.PDR.0000115680.46755.F5</identifier><identifier>PMID: 14764918</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Biological and medical sciences ; Biomechanical Phenomena ; Blood Pressure ; Carotid Artery, Common - pathology ; Child ; Child, Preschool ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; General aspects ; Genetics of eukaryotes. 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To study endothelial function and common carotid artery mechanical properties in children receiving parenteral nutrition, we used noninvasive ultrasonic measurements in 18 children on parenteral nutrition and 18 controls. No difference appeared in the geometry of the common carotid artery (intima media thickness, systolic and diastolic diameters) between the patients on parenteral nutrition and the controls. The incremental elastic modulus was significantly higher in the patients on parenteral nutrition (1.8 +/- 0.4 versus 1.4 +/- 0.5 4 mm Hg x 10(3), p < 0.05) reflecting alteration of the elastic properties of the arterial wall independent of the vessel geometry. The flow-mediated dilatation of the brachial artery was significantly lower in the patients on parenteral nutrition (6 +/- 3 versus 8 +/- 3%, p < 0.05), whereas the dilatation after glyceryl trinitrate administration was similar (22 +/- 9 versus 25 +/- 9%). Children on parenteral nutrition exhibit endothelial dysfunction and altered stiffness of the common carotid artery. The noninvasive methods used in this study may prove useful for objectively determining the effects of various preventive methods.</description><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Biomechanical Phenomena</subject><subject>Blood Pressure</subject><subject>Carotid Artery, Common - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Endothelium, Vascular - pathology</subject><subject>Endothelium, Vascular - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular and cellular biology</subject><subject>Parenteral Nutrition - adverse effects</subject><subject>Time Factors</subject><subject>Tunica Intima - pathology</subject><subject>Tunica Media - pathology</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkFGL1DAQx4Mo3nr6FSQI-taabDJt6pvc3apwoIg-h2k6YSNtsibtw317c97C5iVh5jf_CT_G3knRyr1QH4Vsf9z-bEU9UkJnRKu7HqA9wDO2k6BEI7Tun7OdEEo2ahjMFXtVyp-KazD6JbuSuu_0IM2Opbs4pfVIc8CZ-y26NaTIMU58IXfEGFytn3I6UV4DFZ48rzR3aVkq5zCnNUwc80r5gYdaOYZ5yhR57Z6wPmqjJsRtzeEx-jV74XEu9OZ8X7Pfh7tfN1-b--9fvt18vm-cGvq1GdERovckCQYBoJwHPQo_edyrCQYctDCwH1GbwXRuGpU0ThkFgkib0alr9uEpt_7970ZltUsojuYZI6Wt2F4a0BJEBT89gS6nUjJ5e8phwfxgpbCPuq2Qtuq2F932v257gDr89rxlGxeaLqNnvxV4fwawVJM-Y3ShXDjojeqhU_8A2k2L9A</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>AGGOUN, Yacine</creator><creator>COLOMB, Virginie</creator><creator>TURANLAHTI, Maila</creator><creator>CORRIOL, Odile</creator><creator>GOULET, Olivier</creator><creator>SIDI, Daniel</creator><creator>RICOUR, Claude</creator><creator>BONNET, Damien</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Endothelial function and mechanical properties of the common carotid artery in children on parenteral nutrition</title><author>AGGOUN, Yacine ; COLOMB, Virginie ; TURANLAHTI, Maila ; CORRIOL, Odile ; GOULET, Olivier ; SIDI, Daniel ; RICOUR, Claude ; BONNET, Damien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-baceaaffe1e590553cf54b0fdfa23d59a940852ba48986cdb318c38350ee48bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Biomechanical Phenomena</topic><topic>Blood Pressure</topic><topic>Carotid Artery, Common - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Endothelium, Vascular - pathology</topic><topic>Endothelium, Vascular - physiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular and cellular biology</topic><topic>Parenteral Nutrition - adverse effects</topic><topic>Time Factors</topic><topic>Tunica Intima - pathology</topic><topic>Tunica Media - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AGGOUN, Yacine</creatorcontrib><creatorcontrib>COLOMB, Virginie</creatorcontrib><creatorcontrib>TURANLAHTI, Maila</creatorcontrib><creatorcontrib>CORRIOL, Odile</creatorcontrib><creatorcontrib>GOULET, Olivier</creatorcontrib><creatorcontrib>SIDI, Daniel</creatorcontrib><creatorcontrib>RICOUR, Claude</creatorcontrib><creatorcontrib>BONNET, Damien</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AGGOUN, Yacine</au><au>COLOMB, Virginie</au><au>TURANLAHTI, Maila</au><au>CORRIOL, Odile</au><au>GOULET, Olivier</au><au>SIDI, Daniel</au><au>RICOUR, Claude</au><au>BONNET, Damien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial function and mechanical properties of the common carotid artery in children on parenteral nutrition</atitle><jtitle>Pediatric research</jtitle><addtitle>Pediatr Res</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>55</volume><issue>5</issue><spage>789</spage><epage>793</epage><pages>789-793</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Intravenous administration of nutrition mixtures induces endothelial damage and arterial wall remodeling in animal models. To study endothelial function and common carotid artery mechanical properties in children receiving parenteral nutrition, we used noninvasive ultrasonic measurements in 18 children on parenteral nutrition and 18 controls. No difference appeared in the geometry of the common carotid artery (intima media thickness, systolic and diastolic diameters) between the patients on parenteral nutrition and the controls. The incremental elastic modulus was significantly higher in the patients on parenteral nutrition (1.8 +/- 0.4 versus 1.4 +/- 0.5 4 mm Hg x 10(3), p < 0.05) reflecting alteration of the elastic properties of the arterial wall independent of the vessel geometry. The flow-mediated dilatation of the brachial artery was significantly lower in the patients on parenteral nutrition (6 +/- 3 versus 8 +/- 3%, p < 0.05), whereas the dilatation after glyceryl trinitrate administration was similar (22 +/- 9 versus 25 +/- 9%). Children on parenteral nutrition exhibit endothelial dysfunction and altered stiffness of the common carotid artery. The noninvasive methods used in this study may prove useful for objectively determining the effects of various preventive methods.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>14764918</pmid><doi>10.1203/01.PDR.0000115680.46755.F5</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Biological and medical sciences Biomechanical Phenomena Blood Pressure Carotid Artery, Common - pathology Child Child, Preschool Endothelium, Vascular - pathology Endothelium, Vascular - physiology Female Fundamental and applied biological sciences. Psychology General aspects Genetics of eukaryotes. Biological and molecular evolution Humans Male Medical sciences Molecular and cellular biology Parenteral Nutrition - adverse effects Time Factors Tunica Intima - pathology Tunica Media - pathology |
| title | Endothelial function and mechanical properties of the common carotid artery in children on parenteral nutrition |
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