Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study
The effects of various concentrations (0.0, 1.56, 3.125, 6.25, 12.5, 25, 50 and 100 μg/ml) of the leaf extract of Syzygium cumini Linn. or Eugenia cumini (SC; black plum, Jamun, family Myrtaceae) was studied on the alteration in the radiation-induced micronuclei formation in the cultured human perip...
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| Veröffentlicht in: | Toxicology letters 2002-06, Vol.132 (1), p.19-25 |
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| creator | Jagetia, Ganesh Chandra Baliga, Manjeshwar Shrinath |
| description | The effects of various concentrations (0.0, 1.56, 3.125, 6.25, 12.5, 25, 50 and 100 μg/ml) of the leaf extract of
Syzygium cumini Linn. or
Eugenia cumini (SC; black plum, Jamun, family Myrtaceae) was studied on the alteration in the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes. Treatment of lymphocytes to various concentrations of SC resulted in a dose dependent increase in the micronuclei-induction, especially after 25–100 μg/ml extract. The exposure of human lymphocytes to various concentrations of SC extract before 3 Gy γ-irradiation resulted in a significant decline in the micronuclei-induction at all the drug doses when compared with the non-drug treated irradiated cultures. A nadir in MNBNC frequency was observed for 12.5 μg/ml drug concentration, where the MNBNC frequency was approximately fourfold lower than that of the non-drug treated irradiated cultures. Therefore, this dose may be considered as an optimum dose for radiation protection. Our study demonstrates that the leaf extract of
S. cumini, a plant traditionally used to treat diabetic disorders protects against the radiation-induced DNA damage. |
| doi_str_mv | 10.1016/S0378-4274(02)00032-2 |
| format | Article |
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Syzygium cumini Linn. or
Eugenia cumini (SC; black plum, Jamun, family Myrtaceae) was studied on the alteration in the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes. Treatment of lymphocytes to various concentrations of SC resulted in a dose dependent increase in the micronuclei-induction, especially after 25–100 μg/ml extract. The exposure of human lymphocytes to various concentrations of SC extract before 3 Gy γ-irradiation resulted in a significant decline in the micronuclei-induction at all the drug doses when compared with the non-drug treated irradiated cultures. A nadir in MNBNC frequency was observed for 12.5 μg/ml drug concentration, where the MNBNC frequency was approximately fourfold lower than that of the non-drug treated irradiated cultures. Therefore, this dose may be considered as an optimum dose for radiation protection. Our study demonstrates that the leaf extract of
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Syzygium cumini Linn. or
Eugenia cumini (SC; black plum, Jamun, family Myrtaceae) was studied on the alteration in the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes. Treatment of lymphocytes to various concentrations of SC resulted in a dose dependent increase in the micronuclei-induction, especially after 25–100 μg/ml extract. The exposure of human lymphocytes to various concentrations of SC extract before 3 Gy γ-irradiation resulted in a significant decline in the micronuclei-induction at all the drug doses when compared with the non-drug treated irradiated cultures. A nadir in MNBNC frequency was observed for 12.5 μg/ml drug concentration, where the MNBNC frequency was approximately fourfold lower than that of the non-drug treated irradiated cultures. Therefore, this dose may be considered as an optimum dose for radiation protection. Our study demonstrates that the leaf extract of
S. cumini, a plant traditionally used to treat diabetic disorders protects against the radiation-induced DNA damage.</description><subject>Biological and medical sciences</subject><subject>Biological effects of radiation</subject><subject>Cells, Cultured</subject><subject>DNA Damage - drug effects</subject><subject>DNA Damage - radiation effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eugenia cumini</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gamma radiation</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - radiation effects</subject><subject>Micronuclei</subject><subject>Micronucleus Tests</subject><subject>Myrtaceae - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - drug effects</subject><subject>Plants, Medicinal - chemistry</subject><subject>Radiation-Protective Agents - pharmacology</subject><subject>Radioprotection</subject><subject>Syzygium cumini</subject><subject>Tissues, organs and organisms biophysics</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ctu1TAUBVALgeil8AkgT0DtIOBXnIQJqspbFQwKY-vEPuk1SpzUjpHCF_DZ5D5Ehx1Zstb2sb0Jec7Za864fnPNZFUXSlTqjIlzxpgUhXhANryumkJy3Twkm__khDxJ6deKtNLlY3LCBauV5npD_l4vf5Ybnwdq8-CDp2dfYcjhnEZ02WKi8xZpBOdh9mMofNjtOvr-2wV1MMANUh_2xuZ-zmuIbvMAgU4Y_bTFCD1t-3F0tF-GaTvaZcb0lgKdIvZ-HQhxoWnObnlKHnXQJ3x2XE_Jz48fflx-Lq6-f_pyeXFV2FKxuVCqqTurm47pTjjWgFONLIWTDS8Vl6zVAgS0gjmJddVVkikF0iFj0HailfKUvDqcO8XxNmOazeCTxb6HgGNOpuJ1Kbng90JeK6mZ0issD9DGMaWInZmiH9aHGc7Mriuz78rsijBMmH1XRqy5F8cBuR3Q3aWO5azg5RFAstB3EYL16c5JXTVS79y7g8P13357jCZZj2HtyUe0s3Gjv-cq_wBhcrGj</recordid><startdate>20020607</startdate><enddate>20020607</enddate><creator>Jagetia, Ganesh Chandra</creator><creator>Baliga, Manjeshwar Shrinath</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>20020607</creationdate><title>Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study</title><author>Jagetia, Ganesh Chandra ; Baliga, Manjeshwar Shrinath</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-4498fc69f06f2d09ad49352d39154130b62a2ab20d3e87f73044a3de00abf2b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>Biological effects of radiation</topic><topic>Cells, Cultured</topic><topic>DNA Damage - drug effects</topic><topic>DNA Damage - radiation effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eugenia cumini</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gamma radiation</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - radiation effects</topic><topic>Micronuclei</topic><topic>Micronucleus Tests</topic><topic>Myrtaceae - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - drug effects</topic><topic>Plants, Medicinal - chemistry</topic><topic>Radiation-Protective Agents - pharmacology</topic><topic>Radioprotection</topic><topic>Syzygium cumini</topic><topic>Tissues, organs and organisms biophysics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jagetia, Ganesh Chandra</creatorcontrib><creatorcontrib>Baliga, Manjeshwar Shrinath</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jagetia, Ganesh Chandra</au><au>Baliga, Manjeshwar Shrinath</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2002-06-07</date><risdate>2002</risdate><volume>132</volume><issue>1</issue><spage>19</spage><epage>25</epage><pages>19-25</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>The effects of various concentrations (0.0, 1.56, 3.125, 6.25, 12.5, 25, 50 and 100 μg/ml) of the leaf extract of
Syzygium cumini Linn. or
Eugenia cumini (SC; black plum, Jamun, family Myrtaceae) was studied on the alteration in the radiation-induced micronuclei formation in the cultured human peripheral blood lymphocytes. Treatment of lymphocytes to various concentrations of SC resulted in a dose dependent increase in the micronuclei-induction, especially after 25–100 μg/ml extract. The exposure of human lymphocytes to various concentrations of SC extract before 3 Gy γ-irradiation resulted in a significant decline in the micronuclei-induction at all the drug doses when compared with the non-drug treated irradiated cultures. A nadir in MNBNC frequency was observed for 12.5 μg/ml drug concentration, where the MNBNC frequency was approximately fourfold lower than that of the non-drug treated irradiated cultures. Therefore, this dose may be considered as an optimum dose for radiation protection. Our study demonstrates that the leaf extract of
S. cumini, a plant traditionally used to treat diabetic disorders protects against the radiation-induced DNA damage.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>12084616</pmid><doi>10.1016/S0378-4274(02)00032-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Biological effects of radiation Cells, Cultured DNA Damage - drug effects DNA Damage - radiation effects Dose-Response Relationship, Drug Eugenia cumini Fundamental and applied biological sciences. Psychology Gamma radiation Humans Lymphocytes Lymphocytes - drug effects Lymphocytes - radiation effects Micronuclei Micronucleus Tests Myrtaceae - chemistry Plant Extracts - pharmacology Plant Leaves - drug effects Plants, Medicinal - chemistry Radiation-Protective Agents - pharmacology Radioprotection Syzygium cumini Tissues, organs and organisms biophysics |
| title | Syzygium cumini (Jamun) reduces the radiation-induced DNA damage in the cultured human peripheral blood lymphocytes: a preliminary study |
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