Determination of tiamulin in Type C medicated swine feeds using high throughput extraction with liquid chromatography
An improved method for extraction and analysis of tiamulin is presented to address issues that arose during routine analysis of Type C medicated swine feeds under the current U.S. Food and Drug Administration-Center for Veterinary Medicine (FDA-CVM) approved method. The issues included the need for...
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| Veröffentlicht in: | Journal of AOAC International 2002-05, Vol.85 (3), p.533-540 |
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| container_title | Journal of AOAC International |
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| creator | MOORE, Douglas B BRITTON, Nancy L SMALLIDGE, Robert L RITER, Ken L |
| description | An improved method for extraction and analysis of tiamulin is presented to address issues that arose during routine analysis of Type C medicated swine feeds under the current U.S. Food and Drug Administration-Center for Veterinary Medicine (FDA-CVM) approved method. The issues included the need for higher sample throughput and the ability to accommodate a wider variety of feed matrixes. Changes to the FDA-CVM approved method include reduced sample size and solvent volumes, phosphate buffering of tartaric acid, centrifugation, and use of a new liquid chromatography column and adjusted mobile phase composition. A paired sample study was performed to compare performance of the new and existing methods. The paired sample study showed no statistical difference between sample means of paired sets of 17 samples analyzed by both methods (t = 1.95 at 0.05 significance level, p = 0.068). A recovery study showed the method precision to be 2.06% (coefficient of variation) with an average standard recoveryof 95.8%. Ruggedness test results indicated good overall ruggedness of the method. |
| doi_str_mv | 10.1093/jaoac/85.3.533 |
| format | Article |
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The issues included the need for higher sample throughput and the ability to accommodate a wider variety of feed matrixes. Changes to the FDA-CVM approved method include reduced sample size and solvent volumes, phosphate buffering of tartaric acid, centrifugation, and use of a new liquid chromatography column and adjusted mobile phase composition. A paired sample study was performed to compare performance of the new and existing methods. The paired sample study showed no statistical difference between sample means of paired sets of 17 samples analyzed by both methods (t = 1.95 at 0.05 significance level, p = 0.068). A recovery study showed the method precision to be 2.06% (coefficient of variation) with an average standard recoveryof 95.8%. Ruggedness test results indicated good overall ruggedness of the method.</description><subject>Animal Feed - analysis</subject><subject>Animal productions</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Liquid - methods</subject><subject>Diterpenes - analysis</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Swine</topic><topic>Terrestrial animal productions</topic><topic>Vertebrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MOORE, Douglas B</creatorcontrib><creatorcontrib>BRITTON, Nancy L</creatorcontrib><creatorcontrib>SMALLIDGE, Robert L</creatorcontrib><creatorcontrib>RITER, Ken L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of AOAC International</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MOORE, Douglas B</au><au>BRITTON, Nancy L</au><au>SMALLIDGE, Robert L</au><au>RITER, Ken L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of tiamulin in Type C medicated swine feeds using high throughput extraction with liquid chromatography</atitle><jtitle>Journal of AOAC International</jtitle><addtitle>J AOAC Int</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>85</volume><issue>3</issue><spage>533</spage><epage>540</epage><pages>533-540</pages><issn>1060-3271</issn><eissn>1944-7922</eissn><abstract>An improved method for extraction and analysis of tiamulin is presented to address issues that arose during routine analysis of Type C medicated swine feeds under the current U.S. Food and Drug Administration-Center for Veterinary Medicine (FDA-CVM) approved method. 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| ispartof | Journal of AOAC International, 2002-05, Vol.85 (3), p.533-540 |
| issn | 1060-3271 1944-7922 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Animal Feed - analysis Animal productions Animals Biological and medical sciences Chromatography, Liquid - methods Diterpenes - analysis Fundamental and applied biological sciences. Psychology Swine Terrestrial animal productions Vertebrates |
| title | Determination of tiamulin in Type C medicated swine feeds using high throughput extraction with liquid chromatography |
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