MDR1 gene expression in peripheral blood mononuclear cells after liver transplantation

The multidrug resistance pump, P-glycoprotein 170 (P-gp), the MDR1 gene expression product, is expressed in peripheral blood mononuclear cells (PBMC). Cyclosporine (CsA) and tacrolimus are inhibitors and substrates of the pump, and can induce its expression. The aim of the present study was to asses...

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Veröffentlicht in:	Transplantation 2002-06, Vol.73 (11), p.1824-1828
Hauptverfasser:	GRUDE, Pascale, BOLESLAWSKI, Emmanuel, CONTI, Filomena, CHOUZENOUX, Sandrine, CALMUS, Yvon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics Biological and medical sciences CD3 Complex - analysis Cyclosporine - administration & dosage Female Gene Expression - drug effects Gene Expression - immunology Graft Rejection - drug therapy Graft Rejection - immunology Humans Immunosuppressive Agents - administration & dosage Leukocytes, Mononuclear - chemistry Leukocytes, Mononuclear - physiology Liver Transplantation - immunology Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Middle Aged RNA, Messenger - analysis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tacrolimus - administration & dosage
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