In Vivo Effects of the Epstein–Barr Virus Small RNA EBER-1 on Protein Synthesis and Cell Growth Regulation

Recent studies have suggested a role for the Epstein–Barr virus-encoded RNA EBER-1 in malignant transformation. EBER-1 inhibits the activity of the protein kinase PKR, an inhibitor of protein synthesis with tumour suppressor properties. In human 293 cells and murine embryonic fibroblasts, transient...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2002-06, Vol.297 (2), p.253-269
Hauptverfasser:	Laing, Kenneth G., Elia, Androulla, Jeffrey, Ian, Matys, Volker, Tilleray, Vivienne J., Souberbielle, Bernard, Clemens, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division Cell Line Cell Line, Transformed Cell Transformation, Viral EBER-1 RNA eIF-2 Kinase - metabolism Epstein–Barr virus fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Fibroblasts - virology Gene Expression Regulation growth regulation Herpesvirus 4, Human - pathogenicity Humans malignant transformation Mice Neoplasms - physiopathology Protein Biosynthesis protein kinase R protein synthesis RNA, Viral - physiology Transfection tumourigenesis
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