Resistance of mitochondrial DNA-deficient cells to TRAIL: Role of Bax in TRAIL-induced apoptosis

Mitochondrion is one of the master players in both apoptosis and necrosis. We studied the role of mitochondrial function in TRAIL-induced apoptosis. TRAIL killed SK-Hep1 cells with characteristic features of apoptosis such as DNA fragmentation, sub-G1 ploidy peak and cytochrome c translocation. In c...

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Veröffentlicht in:	Oncogene 2002-05, Vol.21 (20), p.3139-3148
Hauptverfasser:	KIM, Ja-Young, KIM, Yun-Hee, INIK CHANG, SUNSHIN KIM, YOUNGMI KIM PAK, OH, Byung-Ha, YAGITA, Hideo, YONG KEUN JUNG, YOUNG JOON OH, LEE, Myung-Shik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - physiology Ageing, cell death Apoptosis Apoptosis - drug effects Apoptosis - physiology Apoptosis Regulatory Proteins bcl-2-Associated X Protein BH3 Interacting Domain Death Agonist Protein Biological and medical sciences Cancer Carcinoma, Hepatocellular - pathology Carrier Proteins - metabolism Caspase 3 Caspase 8 Caspase 9 Caspases - biosynthesis Caspases - metabolism Cell death Cell physiology Cysteine Proteinase Inhibitors - pharmacology Cytochrome Cytochrome c Cytochrome c Group - metabolism DNA fragmentation DNA, Mitochondrial - drug effects DNA, Mitochondrial - physiology Enzyme Induction Ethidium - pharmacology Fundamental and applied biological sciences. Psychology Genetic aspects Health aspects Humans Intracellular Membranes - ultrastructure Life sciences Liver Neoplasms - pathology Membrane Glycoproteins - antagonists & inhibitors Membrane Glycoproteins - pharmacology Membrane Glycoproteins - physiology Membrane Potentials Mitochondria Mitochondria - physiology Mitochondria - ultrastructure Mitochondrial DNA Molecular and cellular biology Phosphorylation Physiological aspects Ploidy Protein Transport Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-bcl-2 Signal transduction Staurosporine TNF-Related Apoptosis-Inducing Ligand Tumor cells Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - pharmacology Tumor Necrosis Factor-alpha - physiology Tumor necrosis factor-α
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