Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

Transforming growth factor β (TGF-β) induces both apoptosis and cell-cycle arrest in some cell lines, but only growth arrest in others 1 . It is not clear how this differential response to TGF-β is specified. Smad proteins are critical mediators of TGF-β signalling. After stimulation by TGF-β, Smad2...

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Veröffentlicht in:	Nature Cell Biology 2004-04, Vol.6 (4), p.366-372
Hauptverfasser:	Conery, Andrew R., Cao, Yanna, Thompson, E. Aubrey, Townsend, Courtney M., Ko, Tien C., Luo, Kunxin
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - drug effects Active Transport, Cell Nucleus - genetics APOPTOSIS Apoptosis - drug effects Apoptosis - genetics BASIC BIOLOGICAL SCIENCES Biomedical and Life Sciences Cancer Research Cell Biology Cell Line Cell Nucleus - genetics Cell Nucleus - metabolism Cytoplasm - genetics Cytoplasm - metabolism Developmental Biology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene expression Humans LAWRENCE BERKELEY LABORATORY letter Life Sciences Phosphatidylinositol 3-Kinases - genetics Phosphorylation - drug effects Physiological aspects Protein kinases Protein-Serine-Threonine Kinases Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt SENSITIVITY Signal Transduction - drug effects Signal Transduction - genetics Smad3 Protein Stem Cells Trans-Activators - genetics Trans-Activators - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Transforming growth factors
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