Neonatal exposure to endocrine disruptors suppresses juvenile testis weight and steroidogenesis but spermatogenesis is considerably restored during puberty
Neonatal exposure to endocrine disruptors induces developmental abnormalities in the male reproductive system. As to investigate whether neonatal exposure affects spermatogenesis in juvenile and pubertal testes, Sprague–Dawley rat pups were given various endocrine disruptors by a single injection on...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2002-07, Vol.295 (1), p.193-197 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Kuwada, Masahiro Kawashima, Rei Nakamura, Kazuo Kojima, Hisako Hasumi, Hideyo Maki, Jun Sugano, Sachiko |
| description | Neonatal exposure to endocrine disruptors induces developmental abnormalities in the male reproductive system. As to investigate whether neonatal exposure affects spermatogenesis in juvenile and pubertal testes, Sprague–Dawley rat pups were given various endocrine disruptors by a single injection on the day of birth at concentrations ranging between 4
μM and 40
mM and sacrificed on day 21 (juvenile) or 50 (puberty). The testes were weighed and examined histologically at each stage. Further, the metabolites of steroidogenesis were analyzed using normal-phase high performance liquid chromatography. Neonatal exposure significantly reduced testis weights and steroid biosynthesis of juveniles, but they were highly restored at puberty. |
| doi_str_mv | 10.1016/S0006-291X(02)00644-7 |
| format | Article |
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μM and 40
mM and sacrificed on day 21 (juvenile) or 50 (puberty). The testes were weighed and examined histologically at each stage. Further, the metabolites of steroidogenesis were analyzed using normal-phase high performance liquid chromatography. Neonatal exposure significantly reduced testis weights and steroid biosynthesis of juveniles, but they were highly restored at puberty.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/S0006-291X(02)00644-7</identifier><identifier>PMID: 12083789</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Androgens - biosynthesis ; Animals ; Animals, Newborn ; Endocrine disruptor ; Kinetics ; Male ; Organ Size - drug effects ; Rats ; Rats, Sprague-Dawley ; Sexual Maturation ; Spermatogenesis ; Spermatogenesis - drug effects ; Steroid ; Steroidogenesis ; Testis ; Testis - anatomy & histology ; Testis - drug effects ; Testis - growth & development ; Testis - physiology</subject><ispartof>Biochemical and biophysical research communications, 2002-07, Vol.295 (1), p.193-197</ispartof><rights>2002 Elsevier Science (USA)</rights><rights>(c) 2002 Elsevier Science (USA).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-21ba798cb3578a9a92c49ab55dff1476b4d1fcb4c6fa449b8e916787cf7af56b3</citedby><cites>FETCH-LOGICAL-c361t-21ba798cb3578a9a92c49ab55dff1476b4d1fcb4c6fa449b8e916787cf7af56b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X02006447$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12083789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kuwada, Masahiro</creatorcontrib><creatorcontrib>Kawashima, Rei</creatorcontrib><creatorcontrib>Nakamura, Kazuo</creatorcontrib><creatorcontrib>Kojima, Hisako</creatorcontrib><creatorcontrib>Hasumi, Hideyo</creatorcontrib><creatorcontrib>Maki, Jun</creatorcontrib><creatorcontrib>Sugano, Sachiko</creatorcontrib><title>Neonatal exposure to endocrine disruptors suppresses juvenile testis weight and steroidogenesis but spermatogenesis is considerably restored during puberty</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Neonatal exposure to endocrine disruptors induces developmental abnormalities in the male reproductive system. As to investigate whether neonatal exposure affects spermatogenesis in juvenile and pubertal testes, Sprague–Dawley rat pups were given various endocrine disruptors by a single injection on the day of birth at concentrations ranging between 4
μM and 40
mM and sacrificed on day 21 (juvenile) or 50 (puberty). The testes were weighed and examined histologically at each stage. Further, the metabolites of steroidogenesis were analyzed using normal-phase high performance liquid chromatography. Neonatal exposure significantly reduced testis weights and steroid biosynthesis of juveniles, but they were highly restored at puberty.</description><subject>Androgens - biosynthesis</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Endocrine disruptor</subject><subject>Kinetics</subject><subject>Male</subject><subject>Organ Size - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sexual Maturation</subject><subject>Spermatogenesis</subject><subject>Spermatogenesis - drug effects</subject><subject>Steroid</subject><subject>Steroidogenesis</subject><subject>Testis</subject><subject>Testis - anatomy & histology</subject><subject>Testis - drug effects</subject><subject>Testis - growth & development</subject><subject>Testis - physiology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi1ERbeFRwD5hOCQYmedOD6hqoKCVJUDIHGz_GeyuMrGwWOX7rPwsrjdVTkiWRpr_Jv5PPMR8pKzM854_-4rY6xvWsV_vGHt23oXopFPyIozxZqWM_GUrB6RY3KCeMMY56JXz8gxb9mwloNakT_XEGeTzUThbolYEtAcKcw-uhRmoD5gKkuOCSmWZUmACEhvyi3MYaosYA5If0PY_MzUzJ5ihhSDjxuYAeuTLZniAmlr8mOuHhdnDB6SsdOO1q5VATz1pYpu6FIspLx7To5GMyG8OMRT8v3jh28Xn5qrL5efL86vGrfuea7DWiPV4Oy6k4NRRrVOKGO7zo8jF7K3wvPRWeH60Qih7ACK93KQbpRm7Hq7PiWv932XFH-V-he9DehgmswMsaCWfOiY6FkFuz3oUkRMMOolha1JO82ZvndFP7ii71euWasfXNGy1r06CBS7Bf-v6mBDBd7vAahj3gZIGl2A2YEPCVzWPob_SPwF7pajYw</recordid><startdate>20020705</startdate><enddate>20020705</enddate><creator>Kuwada, Masahiro</creator><creator>Kawashima, Rei</creator><creator>Nakamura, Kazuo</creator><creator>Kojima, Hisako</creator><creator>Hasumi, Hideyo</creator><creator>Maki, Jun</creator><creator>Sugano, Sachiko</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020705</creationdate><title>Neonatal exposure to endocrine disruptors suppresses juvenile testis weight and steroidogenesis but spermatogenesis is considerably restored during puberty</title><author>Kuwada, Masahiro ; Kawashima, Rei ; Nakamura, Kazuo ; Kojima, Hisako ; Hasumi, Hideyo ; Maki, Jun ; Sugano, Sachiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-21ba798cb3578a9a92c49ab55dff1476b4d1fcb4c6fa449b8e916787cf7af56b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Androgens - biosynthesis</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Endocrine disruptor</topic><topic>Kinetics</topic><topic>Male</topic><topic>Organ Size - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sexual Maturation</topic><topic>Spermatogenesis</topic><topic>Spermatogenesis - drug effects</topic><topic>Steroid</topic><topic>Steroidogenesis</topic><topic>Testis</topic><topic>Testis - anatomy & histology</topic><topic>Testis - drug effects</topic><topic>Testis - growth & development</topic><topic>Testis - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuwada, Masahiro</creatorcontrib><creatorcontrib>Kawashima, Rei</creatorcontrib><creatorcontrib>Nakamura, Kazuo</creatorcontrib><creatorcontrib>Kojima, Hisako</creatorcontrib><creatorcontrib>Hasumi, Hideyo</creatorcontrib><creatorcontrib>Maki, Jun</creatorcontrib><creatorcontrib>Sugano, Sachiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuwada, Masahiro</au><au>Kawashima, Rei</au><au>Nakamura, Kazuo</au><au>Kojima, Hisako</au><au>Hasumi, Hideyo</au><au>Maki, Jun</au><au>Sugano, Sachiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal exposure to endocrine disruptors suppresses juvenile testis weight and steroidogenesis but spermatogenesis is considerably restored during puberty</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2002-07-05</date><risdate>2002</risdate><volume>295</volume><issue>1</issue><spage>193</spage><epage>197</epage><pages>193-197</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Neonatal exposure to endocrine disruptors induces developmental abnormalities in the male reproductive system. 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μM and 40
mM and sacrificed on day 21 (juvenile) or 50 (puberty). The testes were weighed and examined histologically at each stage. Further, the metabolites of steroidogenesis were analyzed using normal-phase high performance liquid chromatography. Neonatal exposure significantly reduced testis weights and steroid biosynthesis of juveniles, but they were highly restored at puberty.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12083789</pmid><doi>10.1016/S0006-291X(02)00644-7</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 2002-07, Vol.295 (1), p.193-197 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Androgens - biosynthesis Animals Animals, Newborn Endocrine disruptor Kinetics Male Organ Size - drug effects Rats Rats, Sprague-Dawley Sexual Maturation Spermatogenesis Spermatogenesis - drug effects Steroid Steroidogenesis Testis Testis - anatomy & histology Testis - drug effects Testis - growth & development Testis - physiology |
| title | Neonatal exposure to endocrine disruptors suppresses juvenile testis weight and steroidogenesis but spermatogenesis is considerably restored during puberty |
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