HFE mutations, hepatic iron, and fibrosis: Ethnic-specific association of NASH with C282Y but not with fibrotic severity

There is conflicting evidence regarding inheritance of hemochromatosis gene (HFE) mutations and influence of hepatic iron deposition as cofactors for development of fibrosis in patients with nonalcoholic steatohepatitis (NASH). We studied hepatic iron content (Perls' stain grade), frequency of...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2002-07, Vol.36 (1), p.142-149
Hauptverfasser:	Chitturi, Shivakumar, Weltman, Martin, Farrell, Geoffrey C., McDonald, David, Liddle, Christopher, Samarasinghe, Dev, Lin, Rita, Abeygunasekera, Shehan, George, Jacob
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Australia Biological and medical sciences Biopsy Cohort Studies Ethnic Groups Fatty Liver - complications Fatty Liver - ethnology Fatty Liver - genetics Female Ferritins - blood Gastroenterology. Liver. Pancreas. Abdomen Hemochromatosis Protein Heterozygote Histocompatibility Antigens Class I - genetics HLA Antigens - genetics Homozygote Humans Iron - metabolism Liver - metabolism Liver - pathology Liver Cirrhosis - etiology Liver Cirrhosis - genetics Liver Cirrhosis - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Membrane Proteins Middle Aged Mutation Other diseases. Semiology Prospective Studies Transferrin - metabolism
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