Genetic variation of the protease and reverse transcriptase genes in HIV-1 CRF04―cpx strains
To gain information about the genetic variation of the protease and reverse transcriptase gene-coding regions in HIV-1 strains belonging to CRF04_cpx, genotyping and drug susceptibility testing were performed on serum samples derived from seven patients carrying sequences belonging to this circulati...
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| Veröffentlicht in: | AIDS research and human retroviruses 2002-06, Vol.18 (9), p.677-680 |
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| container_end_page | 680 |
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| container_title | AIDS research and human retroviruses |
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| creator | PAPA, Anna PAPADIMITRIOU, Evagelia PAPOUTSI, Androniki MALISSIOVAS, Nikolaos KIOSSES, Vassilios G ANTONIADIS, Antonis |
| description | To gain information about the genetic variation of the protease and reverse transcriptase gene-coding regions in HIV-1 strains belonging to CRF04_cpx, genotyping and drug susceptibility testing were performed on serum samples derived from seven patients carrying sequences belonging to this circulating recombinant form. Substitutions classically associated with resistance to antiretroviral drugs were observed in six of seven samples, including G48V, V82A, L90M, M46I in the protease protein, and K70R, D69D/N, M184V, T215F, K103N in the reverse transcriptase protein. Genotypic resistance patterns of CRF04_cpx samples were found to be similar to those identified in subtype B viruses, suggesting that the drug-selective pressure has similar effects on both subtype B and CRF04_cpx. |
| doi_str_mv | 10.1089/088922202760019392 |
| format | Article |
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Substitutions classically associated with resistance to antiretroviral drugs were observed in six of seven samples, including G48V, V82A, L90M, M46I in the protease protein, and K70R, D69D/N, M184V, T215F, K103N in the reverse transcriptase protein. Genotypic resistance patterns of CRF04_cpx samples were found to be similar to those identified in subtype B viruses, suggesting that the drug-selective pressure has similar effects on both subtype B and CRF04_cpx.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/088922202760019392</identifier><identifier>PMID: 12079565</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS/HIV ; Amino Acid Sequence ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Drug Resistance, Viral - genetics ; Genetic Variation ; Genotype ; HIV Protease - genetics ; HIV Reverse Transcriptase - genetics ; HIV-1 - enzymology ; HIV-1 - genetics ; Medical sciences ; Molecular Sequence Data ; Pharmacology. 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Substitutions classically associated with resistance to antiretroviral drugs were observed in six of seven samples, including G48V, V82A, L90M, M46I in the protease protein, and K70R, D69D/N, M184V, T215F, K103N in the reverse transcriptase protein. Genotypic resistance patterns of CRF04_cpx samples were found to be similar to those identified in subtype B viruses, suggesting that the drug-selective pressure has similar effects on both subtype B and CRF04_cpx.</description><subject>AIDS/HIV</subject><subject>Amino Acid Sequence</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>HIV Protease - genetics</subject><subject>HIV Reverse Transcriptase - genetics</subject><subject>HIV-1 - enzymology</subject><subject>HIV-1 - genetics</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Pharmacology. 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| ispartof | AIDS research and human retroviruses, 2002-06, Vol.18 (9), p.677-680 |
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| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Amino Acid Sequence Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Drug Resistance, Viral - genetics Genetic Variation Genotype HIV Protease - genetics HIV Reverse Transcriptase - genetics HIV-1 - enzymology HIV-1 - genetics Medical sciences Molecular Sequence Data Pharmacology. Drug treatments Point Mutation Sequence Homology, Amino Acid |
| title | Genetic variation of the protease and reverse transcriptase genes in HIV-1 CRF04―cpx strains |
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