Imidazoline I(2) receptor density increases with the malignancy of human gliomas
Current glioma grading schemes are limited by subjective histological criteria. Imidazoline I(2) receptors are principally expressed on glial cells. To investigate the feasibility of using the measurement of imidazoline I(2) receptor expression to differentiate glial tumours from other types of brai...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2004-05, Vol.75 (5), p.785-787 |
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| container_title | Journal of neurology, neurosurgery and psychiatry |
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| creator | Callado, L F Martín-Gómez, J I Ruiz, J Garibi, J M Meana, J J |
| description | Current glioma grading schemes are limited by subjective histological criteria. Imidazoline I(2) receptors are principally expressed on glial cells.
To investigate the feasibility of using the measurement of imidazoline I(2) receptor expression to differentiate glial tumours from other types of brain tumours and for grading the different gliomas.
The specific binding of [(3)H]idazoxan to imidazoline I(2) receptors was measured in homogenates from human gliomas of different grades.
The density of imidazoline I(2) receptors was significantly greater in the three types of malignant glial tumours than in postmortem control brain or non-glial tumours. The increase in density correlated with the malignancy grade of the gliomas. No significant differences in affinity values were observed.
These results suggest that the density of imidazoline I(2) receptors may be a useful radioligand parameter for the differentiation of glial tumours from other types of brain tumours and for grading the different gliomas. |
| format | Article |
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To investigate the feasibility of using the measurement of imidazoline I(2) receptor expression to differentiate glial tumours from other types of brain tumours and for grading the different gliomas.
The specific binding of [(3)H]idazoxan to imidazoline I(2) receptors was measured in homogenates from human gliomas of different grades.
The density of imidazoline I(2) receptors was significantly greater in the three types of malignant glial tumours than in postmortem control brain or non-glial tumours. The increase in density correlated with the malignancy grade of the gliomas. No significant differences in affinity values were observed.
These results suggest that the density of imidazoline I(2) receptors may be a useful radioligand parameter for the differentiation of glial tumours from other types of brain tumours and for grading the different gliomas.</description><identifier>ISSN: 0022-3050</identifier><identifier>PMID: 15090584</identifier><language>eng</language><publisher>England</publisher><subject>Binding Sites ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Cell Count ; Feasibility Studies ; Glial Fibrillary Acidic Protein - metabolism ; Glioma - classification ; Glioma - metabolism ; Glioma - pathology ; Humans ; Idazoxan - metabolism ; Imidazoline Receptors ; Neoplasm Staging ; Receptors, Drug - metabolism</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2004-05, Vol.75 (5), p.785-787</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15090584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Callado, L F</creatorcontrib><creatorcontrib>Martín-Gómez, J I</creatorcontrib><creatorcontrib>Ruiz, J</creatorcontrib><creatorcontrib>Garibi, J M</creatorcontrib><creatorcontrib>Meana, J J</creatorcontrib><title>Imidazoline I(2) receptor density increases with the malignancy of human gliomas</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>Current glioma grading schemes are limited by subjective histological criteria. Imidazoline I(2) receptors are principally expressed on glial cells.
To investigate the feasibility of using the measurement of imidazoline I(2) receptor expression to differentiate glial tumours from other types of brain tumours and for grading the different gliomas.
The specific binding of [(3)H]idazoxan to imidazoline I(2) receptors was measured in homogenates from human gliomas of different grades.
The density of imidazoline I(2) receptors was significantly greater in the three types of malignant glial tumours than in postmortem control brain or non-glial tumours. The increase in density correlated with the malignancy grade of the gliomas. No significant differences in affinity values were observed.
These results suggest that the density of imidazoline I(2) receptors may be a useful radioligand parameter for the differentiation of glial tumours from other types of brain tumours and for grading the different gliomas.</description><subject>Binding Sites</subject><subject>Brain Neoplasms - metabolism</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Count</subject><subject>Feasibility Studies</subject><subject>Glial Fibrillary Acidic Protein - metabolism</subject><subject>Glioma - classification</subject><subject>Glioma - metabolism</subject><subject>Glioma - pathology</subject><subject>Humans</subject><subject>Idazoxan - metabolism</subject><subject>Imidazoline Receptors</subject><subject>Neoplasm Staging</subject><subject>Receptors, Drug - metabolism</subject><issn>0022-3050</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kLtOwzAYRj2AaCm8AvKEYIjka-yMqOJSqRIM3SPH-dMY2U6wE6Hw9IAoZ_mWo284Z2hNCGMFJ5Ks0GXO7-QXXV2gFZWkIlKLNXrbBdear8G7CHh3x-5xAgvjNCTcQsxuWrCLNoHJkPGnm3o89YCD8e4YTbQLHjrcz8FEfPRuCCZfofPO-AzXp92gw9PjYftS7F-fd9uHfTFKIQoracUUt0BFJauWSsaa0pQgTCMVAa2aiiqlBHBOOKeWamk410qLruGMA9-g27_bMQ0fM-SpDi5b8N5EGOZcK6qFKgX7EW9O4twEaOsxuWDSUv8n4N9uUVVV</recordid><startdate>200405</startdate><enddate>200405</enddate><creator>Callado, L F</creator><creator>Martín-Gómez, J I</creator><creator>Ruiz, J</creator><creator>Garibi, J M</creator><creator>Meana, J J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200405</creationdate><title>Imidazoline I(2) receptor density increases with the malignancy of human gliomas</title><author>Callado, L F ; Martín-Gómez, J I ; Ruiz, J ; Garibi, J M ; Meana, J J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p544-c519273ce14959d1522b6a6e4ab570e87b917774e330331c185a338784fb323e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Binding Sites</topic><topic>Brain Neoplasms - metabolism</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Count</topic><topic>Feasibility Studies</topic><topic>Glial Fibrillary Acidic Protein - metabolism</topic><topic>Glioma - classification</topic><topic>Glioma - metabolism</topic><topic>Glioma - pathology</topic><topic>Humans</topic><topic>Idazoxan - metabolism</topic><topic>Imidazoline Receptors</topic><topic>Neoplasm Staging</topic><topic>Receptors, Drug - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Callado, L F</creatorcontrib><creatorcontrib>Martín-Gómez, J I</creatorcontrib><creatorcontrib>Ruiz, J</creatorcontrib><creatorcontrib>Garibi, J M</creatorcontrib><creatorcontrib>Meana, J J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Callado, L F</au><au>Martín-Gómez, J I</au><au>Ruiz, J</au><au>Garibi, J M</au><au>Meana, J J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imidazoline I(2) receptor density increases with the malignancy of human gliomas</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2004-05</date><risdate>2004</risdate><volume>75</volume><issue>5</issue><spage>785</spage><epage>787</epage><pages>785-787</pages><issn>0022-3050</issn><abstract>Current glioma grading schemes are limited by subjective histological criteria. Imidazoline I(2) receptors are principally expressed on glial cells.
To investigate the feasibility of using the measurement of imidazoline I(2) receptor expression to differentiate glial tumours from other types of brain tumours and for grading the different gliomas.
The specific binding of [(3)H]idazoxan to imidazoline I(2) receptors was measured in homogenates from human gliomas of different grades.
The density of imidazoline I(2) receptors was significantly greater in the three types of malignant glial tumours than in postmortem control brain or non-glial tumours. The increase in density correlated with the malignancy grade of the gliomas. No significant differences in affinity values were observed.
These results suggest that the density of imidazoline I(2) receptors may be a useful radioligand parameter for the differentiation of glial tumours from other types of brain tumours and for grading the different gliomas.</abstract><cop>England</cop><pmid>15090584</pmid><tpages>3</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Binding Sites Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Count Feasibility Studies Glial Fibrillary Acidic Protein - metabolism Glioma - classification Glioma - metabolism Glioma - pathology Humans Idazoxan - metabolism Imidazoline Receptors Neoplasm Staging Receptors, Drug - metabolism |
| title | Imidazoline I(2) receptor density increases with the malignancy of human gliomas |
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