Arterial stiffness and endothelial dysfunction in HIV-infected children
The role of antiretroviral therapy in acceleration of atherosclerosis in HIV-infected adults is controversial, partly because of the confounding effects of the involvement of classic cardiovascular risk factors. To study vascular function in HIV-infected children. Cross-sectional study of 49 HIV-inf...
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| Veröffentlicht in: | AIDS (London) 2004-04, Vol.18 (7), p.1037-1041 |
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| creator | BONNET, Damien AGGOUN, Yacine SZEZEPANSKI, Isabelle BELLAL, Nassima BLANCHE, Stéphane |
| description | The role of antiretroviral therapy in acceleration of atherosclerosis in HIV-infected adults is controversial, partly because of the confounding effects of the involvement of classic cardiovascular risk factors.
To study vascular function in HIV-infected children.
Cross-sectional study of 49 HIV-infected children (34 receiving antiretroviral therapy and 15 never treated) and if 24 age- and sex-matched controls.
Automatic, computerized, ultrasonic procedure evaluation of geometric and mechanical properties of the common carotid artery, and of the endothelium-dependent dilation and endothelium-independent dilation.
Relative systolodiastolic variations in diameter of the carotid artery in HIV-infected children were significantly lower than those in controls, but there was no significant difference in intima-media thickness. Cross-sectional compliance and distensibility were also significantly lower. Wall stiffness, assessed as the incremental elastic modulus, was larger in HIV-infected children. Endothelium-dependent dilation was lower in HIV-infected children but non-endothelium-dependent dilation was similar to that in controls. We did not find differences for any of the vascular variables between HIV-infected children receiving antiretroviral therapy and those never treated. All arterial variables were similar in children with and without dyslipidemia.
HIV-infected children had a vascular dysfunction in the absence of cardiovascular risk factors. In this short series, no additional detrimental effects were observed after a mean of 5 years of antiretroviral therapy. |
| doi_str_mv | 10.1097/00002030-200404300-00012 |
| format | Article |
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To study vascular function in HIV-infected children.
Cross-sectional study of 49 HIV-infected children (34 receiving antiretroviral therapy and 15 never treated) and if 24 age- and sex-matched controls.
Automatic, computerized, ultrasonic procedure evaluation of geometric and mechanical properties of the common carotid artery, and of the endothelium-dependent dilation and endothelium-independent dilation.
Relative systolodiastolic variations in diameter of the carotid artery in HIV-infected children were significantly lower than those in controls, but there was no significant difference in intima-media thickness. Cross-sectional compliance and distensibility were also significantly lower. Wall stiffness, assessed as the incremental elastic modulus, was larger in HIV-infected children. Endothelium-dependent dilation was lower in HIV-infected children but non-endothelium-dependent dilation was similar to that in controls. We did not find differences for any of the vascular variables between HIV-infected children receiving antiretroviral therapy and those never treated. All arterial variables were similar in children with and without dyslipidemia.
HIV-infected children had a vascular dysfunction in the absence of cardiovascular risk factors. In this short series, no additional detrimental effects were observed after a mean of 5 years of antiretroviral therapy.</description><identifier>ISSN: 0269-9370</identifier><identifier>EISSN: 1473-5571</identifier><identifier>DOI: 10.1097/00002030-200404300-00012</identifier><identifier>PMID: 15096807</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Adult ; AIDS/HIV ; Anthropometry ; Anti-HIV Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; Biological and medical sciences ; Brachial Artery - physiopathology ; Carotid Artery, Common - diagnostic imaging ; Carotid Artery, Common - drug effects ; Carotid Artery, Common - physiopathology ; Child ; Child, Preschool ; Cross-Sectional Studies ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Female ; HIV Infections - drug therapy ; HIV Infections - physiopathology ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Ultrasonography ; Vascular Resistance - drug effects ; Vasodilation ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids</subject><ispartof>AIDS (London), 2004-04, Vol.18 (7), p.1037-1041</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-7d3aeafb30bdb08bd973ed978733ebf921c23cd8751a268352f2c3e1f0541f183</citedby><cites>FETCH-LOGICAL-c391t-7d3aeafb30bdb08bd973ed978733ebf921c23cd8751a268352f2c3e1f0541f183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15679655$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15096807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BONNET, Damien</creatorcontrib><creatorcontrib>AGGOUN, Yacine</creatorcontrib><creatorcontrib>SZEZEPANSKI, Isabelle</creatorcontrib><creatorcontrib>BELLAL, Nassima</creatorcontrib><creatorcontrib>BLANCHE, Stéphane</creatorcontrib><title>Arterial stiffness and endothelial dysfunction in HIV-infected children</title><title>AIDS (London)</title><addtitle>AIDS</addtitle><description>The role of antiretroviral therapy in acceleration of atherosclerosis in HIV-infected adults is controversial, partly because of the confounding effects of the involvement of classic cardiovascular risk factors.
To study vascular function in HIV-infected children.
Cross-sectional study of 49 HIV-infected children (34 receiving antiretroviral therapy and 15 never treated) and if 24 age- and sex-matched controls.
Automatic, computerized, ultrasonic procedure evaluation of geometric and mechanical properties of the common carotid artery, and of the endothelium-dependent dilation and endothelium-independent dilation.
Relative systolodiastolic variations in diameter of the carotid artery in HIV-infected children were significantly lower than those in controls, but there was no significant difference in intima-media thickness. Cross-sectional compliance and distensibility were also significantly lower. Wall stiffness, assessed as the incremental elastic modulus, was larger in HIV-infected children. Endothelium-dependent dilation was lower in HIV-infected children but non-endothelium-dependent dilation was similar to that in controls. We did not find differences for any of the vascular variables between HIV-infected children receiving antiretroviral therapy and those never treated. All arterial variables were similar in children with and without dyslipidemia.
HIV-infected children had a vascular dysfunction in the absence of cardiovascular risk factors. In this short series, no additional detrimental effects were observed after a mean of 5 years of antiretroviral therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Anthropometry</subject><subject>Anti-HIV Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Brachial Artery - physiopathology</subject><subject>Carotid Artery, Common - diagnostic imaging</subject><subject>Carotid Artery, Common - drug effects</subject><subject>Carotid Artery, Common - physiopathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cross-Sectional Studies</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Female</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - physiopathology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Ultrasonography</subject><subject>Vascular Resistance - drug effects</subject><subject>Vasodilation</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><issn>0269-9370</issn><issn>1473-5571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1PwzAMQCMEYmPwF1AvcCs4SdOkx2mCbdIkLsC1ShNHC-rSkXSH_Xs6Nj58sCX72ZYeIRmFBwqVfIQhGHDIGUABBQfIhw5lZ2RMC8lzISQ9J2NgZZVXXMKIXKX0MSAClLokIyqgKhXIMZlPY4_R6zZLvXcuYEqZDjbDYLt-je1hYvfJ7YLpfRcyH7LF8j33waHp0WZm7VsbMVyTC6fbhDenOiFvz0-vs0W-epkvZ9NVbnhF-1xarlG7hkNjG1CNrSTHISnJOTauYtQwbqySgmpWKi6YY4YjdSAK6qjiE3J_vLuN3ecOU19vfDLYtjpgt0u1pKqQQOUAqiNoYpdSRFdvo9_ouK8p1AeJ9Y_E-ldi_S1xWL09_dg1G7R_iydrA3B3AnQyunVRB-PTP66UVSkE_wKxMXlz</recordid><startdate>20040430</startdate><enddate>20040430</enddate><creator>BONNET, Damien</creator><creator>AGGOUN, Yacine</creator><creator>SZEZEPANSKI, Isabelle</creator><creator>BELLAL, Nassima</creator><creator>BLANCHE, Stéphane</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040430</creationdate><title>Arterial stiffness and endothelial dysfunction in HIV-infected children</title><author>BONNET, Damien ; AGGOUN, Yacine ; SZEZEPANSKI, Isabelle ; BELLAL, Nassima ; BLANCHE, Stéphane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-7d3aeafb30bdb08bd973ed978733ebf921c23cd8751a268352f2c3e1f0541f183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Anthropometry</topic><topic>Anti-HIV Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Brachial Artery - physiopathology</topic><topic>Carotid Artery, Common - diagnostic imaging</topic><topic>Carotid Artery, Common - drug effects</topic><topic>Carotid Artery, Common - physiopathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cross-Sectional Studies</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Female</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - physiopathology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Ultrasonography</topic><topic>Vascular Resistance - drug effects</topic><topic>Vasodilation</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BONNET, Damien</creatorcontrib><creatorcontrib>AGGOUN, Yacine</creatorcontrib><creatorcontrib>SZEZEPANSKI, Isabelle</creatorcontrib><creatorcontrib>BELLAL, Nassima</creatorcontrib><creatorcontrib>BLANCHE, Stéphane</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BONNET, Damien</au><au>AGGOUN, Yacine</au><au>SZEZEPANSKI, Isabelle</au><au>BELLAL, Nassima</au><au>BLANCHE, Stéphane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arterial stiffness and endothelial dysfunction in HIV-infected children</atitle><jtitle>AIDS (London)</jtitle><addtitle>AIDS</addtitle><date>2004-04-30</date><risdate>2004</risdate><volume>18</volume><issue>7</issue><spage>1037</spage><epage>1041</epage><pages>1037-1041</pages><issn>0269-9370</issn><eissn>1473-5571</eissn><abstract>The role of antiretroviral therapy in acceleration of atherosclerosis in HIV-infected adults is controversial, partly because of the confounding effects of the involvement of classic cardiovascular risk factors.
To study vascular function in HIV-infected children.
Cross-sectional study of 49 HIV-infected children (34 receiving antiretroviral therapy and 15 never treated) and if 24 age- and sex-matched controls.
Automatic, computerized, ultrasonic procedure evaluation of geometric and mechanical properties of the common carotid artery, and of the endothelium-dependent dilation and endothelium-independent dilation.
Relative systolodiastolic variations in diameter of the carotid artery in HIV-infected children were significantly lower than those in controls, but there was no significant difference in intima-media thickness. Cross-sectional compliance and distensibility were also significantly lower. Wall stiffness, assessed as the incremental elastic modulus, was larger in HIV-infected children. Endothelium-dependent dilation was lower in HIV-infected children but non-endothelium-dependent dilation was similar to that in controls. We did not find differences for any of the vascular variables between HIV-infected children receiving antiretroviral therapy and those never treated. All arterial variables were similar in children with and without dyslipidemia.
HIV-infected children had a vascular dysfunction in the absence of cardiovascular risk factors. In this short series, no additional detrimental effects were observed after a mean of 5 years of antiretroviral therapy.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15096807</pmid><doi>10.1097/00002030-200404300-00012</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Ovid Autoload |
| subjects | Adolescent Adult AIDS/HIV Anthropometry Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Brachial Artery - physiopathology Carotid Artery, Common - diagnostic imaging Carotid Artery, Common - drug effects Carotid Artery, Common - physiopathology Child Child, Preschool Cross-Sectional Studies Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Female HIV Infections - drug therapy HIV Infections - physiopathology Human viral diseases Humans Infectious diseases Male Medical sciences Pharmacology. Drug treatments Ultrasonography Vascular Resistance - drug effects Vasodilation Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Arterial stiffness and endothelial dysfunction in HIV-infected children |
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