Can Serum CA-125 Levels Predict the Optimal Primary Cytoreduction in Patients with Advanced Ovarian Carcinoma?
Objective. The aim of this study was to investigate the predictive value of serum CA-125 levels to ability of optimal primary cytoreduction in patients with advanced epithelial ovarian carcinoma. Methods. Preoperative serum CA-125 levels were determined by a commercial enzyme immunoassay kit in a se...
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| Veröffentlicht in: | Gynecologic oncology 2002-07, Vol.86 (1), p.57-61 |
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| creator | Saygili, Ugur Guclu, Serkan Uslu, Turhan Erten, Oktay Demir, Namik Onvural, Ata |
| description | Objective. The aim of this study was to investigate the predictive value of serum CA-125 levels to ability of optimal primary cytoreduction in patients with advanced epithelial ovarian carcinoma.
Methods. Preoperative serum CA-125 levels were determined by a commercial enzyme immunoassay kit in a series of 92 patients with stage IIIC epithelial ovarian carcinoma. The abilities of various cutoff value of CA-125 to predict suboptimal cytoreductive surgery were determined. A receiver operating characteristic curve was used to find the most clinically useful CA-125 cutoff value.
Results. Optimal cytoreduction was obtained in 48 patients (52%) using the diameter of the largest residual tumor nodule less than 1 cm. Receiver operating characteristic curve showed that the most clinically suitable CA-125 cutoff value was 500 U/ml. Forty-seven patients (51%) had preoperative serum CA-125 levels below 500 U/ml. Of these patients, optimal cytoreductive surgery was performed in 36 (77%). Of the 45 patients with serum CA-125 levels greater than 500 U/ml, optimal cytoreductive surgery was achieved in 12 (27%). True- and false-positive rates were 73 and 23%, respectively.
Conclusions. Although our results showed that preoperative serum CA-125 levels might predict the optimal resectable patients, larger prospective studies are needed to prove its predictivity. Gynecologic oncologists should evaluate the sum of all criteria until more data are available. |
| doi_str_mv | 10.1006/gyno.2002.6719 |
| format | Article |
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Methods. Preoperative serum CA-125 levels were determined by a commercial enzyme immunoassay kit in a series of 92 patients with stage IIIC epithelial ovarian carcinoma. The abilities of various cutoff value of CA-125 to predict suboptimal cytoreductive surgery were determined. A receiver operating characteristic curve was used to find the most clinically useful CA-125 cutoff value.
Results. Optimal cytoreduction was obtained in 48 patients (52%) using the diameter of the largest residual tumor nodule less than 1 cm. Receiver operating characteristic curve showed that the most clinically suitable CA-125 cutoff value was 500 U/ml. Forty-seven patients (51%) had preoperative serum CA-125 levels below 500 U/ml. Of these patients, optimal cytoreductive surgery was performed in 36 (77%). Of the 45 patients with serum CA-125 levels greater than 500 U/ml, optimal cytoreductive surgery was achieved in 12 (27%). True- and false-positive rates were 73 and 23%, respectively.
Conclusions. Although our results showed that preoperative serum CA-125 levels might predict the optimal resectable patients, larger prospective studies are needed to prove its predictivity. Gynecologic oncologists should evaluate the sum of all criteria until more data are available.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1006/gyno.2002.6719</identifier><identifier>PMID: 12079301</identifier><identifier>CODEN: GYNOA3</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Biological and medical sciences ; CA-125 ; CA-125 Antigen - blood ; Carcinoma - blood ; Carcinoma - pathology ; Carcinoma - surgery ; cytoreduction ; debulking ; Female ; Female genital diseases ; Gynecologic Surgical Procedures - methods ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; Middle Aged ; Neoplasm Staging ; ovarian carcinoma ; Ovarian Neoplasms - blood ; Ovarian Neoplasms - pathology ; Ovarian Neoplasms - surgery ; Predictive Value of Tests ; Preoperative Care ; Retrospective Studies ; ROC Curve ; Sensitivity and Specificity ; Tropical medicine ; Tumors</subject><ispartof>Gynecologic oncology, 2002-07, Vol.86 (1), p.57-61</ispartof><rights>2002 Elsevier Science (USA)</rights><rights>2002 INIST-CNRS</rights><rights>(c) 2002 Elsevier Science (USA).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c370t-74c488e1857a8d068225e30c829ae550f10f53a9e38cf23371c81d09dbb62d7a3</citedby><cites>FETCH-LOGICAL-c370t-74c488e1857a8d068225e30c829ae550f10f53a9e38cf23371c81d09dbb62d7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0090825802967193$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13823812$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12079301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saygili, Ugur</creatorcontrib><creatorcontrib>Guclu, Serkan</creatorcontrib><creatorcontrib>Uslu, Turhan</creatorcontrib><creatorcontrib>Erten, Oktay</creatorcontrib><creatorcontrib>Demir, Namik</creatorcontrib><creatorcontrib>Onvural, Ata</creatorcontrib><title>Can Serum CA-125 Levels Predict the Optimal Primary Cytoreduction in Patients with Advanced Ovarian Carcinoma?</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>Objective. The aim of this study was to investigate the predictive value of serum CA-125 levels to ability of optimal primary cytoreduction in patients with advanced epithelial ovarian carcinoma.
Methods. Preoperative serum CA-125 levels were determined by a commercial enzyme immunoassay kit in a series of 92 patients with stage IIIC epithelial ovarian carcinoma. The abilities of various cutoff value of CA-125 to predict suboptimal cytoreductive surgery were determined. A receiver operating characteristic curve was used to find the most clinically useful CA-125 cutoff value.
Results. Optimal cytoreduction was obtained in 48 patients (52%) using the diameter of the largest residual tumor nodule less than 1 cm. Receiver operating characteristic curve showed that the most clinically suitable CA-125 cutoff value was 500 U/ml. Forty-seven patients (51%) had preoperative serum CA-125 levels below 500 U/ml. Of these patients, optimal cytoreductive surgery was performed in 36 (77%). Of the 45 patients with serum CA-125 levels greater than 500 U/ml, optimal cytoreductive surgery was achieved in 12 (27%). True- and false-positive rates were 73 and 23%, respectively.
Conclusions. Although our results showed that preoperative serum CA-125 levels might predict the optimal resectable patients, larger prospective studies are needed to prove its predictivity. Gynecologic oncologists should evaluate the sum of all criteria until more data are available.</description><subject>Biological and medical sciences</subject><subject>CA-125</subject><subject>CA-125 Antigen - blood</subject><subject>Carcinoma - blood</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>cytoreduction</subject><subject>debulking</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecologic Surgical Procedures - methods</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>ovarian carcinoma</subject><subject>Ovarian Neoplasms - blood</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Ovarian Neoplasms - surgery</subject><subject>Predictive Value of Tests</subject><subject>Preoperative Care</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Sensitivity and Specificity</subject><subject>Tropical medicine</subject><subject>Tumors</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFvEzEQRi0EomnhyhH5ArcNYzu79p5QtIKCFCmV2p4tx56lRrveYHuD8u_rkEg9cZqR_fyN5xHygcGSATRffh3DtOQAfNlI1r4iCwZtXTWqbl-TBUALleK1uiLXKf0GAAGMvyVXjINsS78goTOB3mOcR9qtK8ZrusEDDoneRXTeZpqfkG732Y9mKGelxCPtjnkq17PNfgrUB3pnsseQE_3r8xNdu4MJFh3dHkz0Jb8z0fowjebrO_KmN0PC95d6Qx6_f3voflSb7e3Pbr2prJCQK7myK6WQqVoa5aBRnNcowCreGqxr6Bn0tTAtCmV7LoRkVjEHrdvtGu6kETfk8zl3H6c_M6asR58sDoMJOM1JS6ZWsrgo4PIM2jilFLHX-_OSmoE-GdYnw_pkWJ8MlwcfL8nzbkT3gl-UFuDTBTDJmqGPxYVPL5xQXKh_k9WZK7bx4DHqZIvE4s1HtFm7yf_vD8-VcpZe</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Saygili, Ugur</creator><creator>Guclu, Serkan</creator><creator>Uslu, Turhan</creator><creator>Erten, Oktay</creator><creator>Demir, Namik</creator><creator>Onvural, Ata</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Can Serum CA-125 Levels Predict the Optimal Primary Cytoreduction in Patients with Advanced Ovarian Carcinoma?</title><author>Saygili, Ugur ; Guclu, Serkan ; Uslu, Turhan ; Erten, Oktay ; Demir, Namik ; Onvural, Ata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-74c488e1857a8d068225e30c829ae550f10f53a9e38cf23371c81d09dbb62d7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Biological and medical sciences</topic><topic>CA-125</topic><topic>CA-125 Antigen - blood</topic><topic>Carcinoma - blood</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>cytoreduction</topic><topic>debulking</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecologic Surgical Procedures - methods</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>ovarian carcinoma</topic><topic>Ovarian Neoplasms - blood</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Ovarian Neoplasms - surgery</topic><topic>Predictive Value of Tests</topic><topic>Preoperative Care</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Sensitivity and Specificity</topic><topic>Tropical medicine</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saygili, Ugur</creatorcontrib><creatorcontrib>Guclu, Serkan</creatorcontrib><creatorcontrib>Uslu, Turhan</creatorcontrib><creatorcontrib>Erten, Oktay</creatorcontrib><creatorcontrib>Demir, Namik</creatorcontrib><creatorcontrib>Onvural, Ata</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saygili, Ugur</au><au>Guclu, Serkan</au><au>Uslu, Turhan</au><au>Erten, Oktay</au><au>Demir, Namik</au><au>Onvural, Ata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can Serum CA-125 Levels Predict the Optimal Primary Cytoreduction in Patients with Advanced Ovarian Carcinoma?</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>86</volume><issue>1</issue><spage>57</spage><epage>61</epage><pages>57-61</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><coden>GYNOA3</coden><abstract>Objective. The aim of this study was to investigate the predictive value of serum CA-125 levels to ability of optimal primary cytoreduction in patients with advanced epithelial ovarian carcinoma.
Methods. Preoperative serum CA-125 levels were determined by a commercial enzyme immunoassay kit in a series of 92 patients with stage IIIC epithelial ovarian carcinoma. The abilities of various cutoff value of CA-125 to predict suboptimal cytoreductive surgery were determined. A receiver operating characteristic curve was used to find the most clinically useful CA-125 cutoff value.
Results. Optimal cytoreduction was obtained in 48 patients (52%) using the diameter of the largest residual tumor nodule less than 1 cm. Receiver operating characteristic curve showed that the most clinically suitable CA-125 cutoff value was 500 U/ml. Forty-seven patients (51%) had preoperative serum CA-125 levels below 500 U/ml. Of these patients, optimal cytoreductive surgery was performed in 36 (77%). Of the 45 patients with serum CA-125 levels greater than 500 U/ml, optimal cytoreductive surgery was achieved in 12 (27%). True- and false-positive rates were 73 and 23%, respectively.
Conclusions. Although our results showed that preoperative serum CA-125 levels might predict the optimal resectable patients, larger prospective studies are needed to prove its predictivity. Gynecologic oncologists should evaluate the sum of all criteria until more data are available.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>12079301</pmid><doi>10.1006/gyno.2002.6719</doi><tpages>5</tpages></addata></record> |
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| subjects | Biological and medical sciences CA-125 CA-125 Antigen - blood Carcinoma - blood Carcinoma - pathology Carcinoma - surgery cytoreduction debulking Female Female genital diseases Gynecologic Surgical Procedures - methods Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Staging ovarian carcinoma Ovarian Neoplasms - blood Ovarian Neoplasms - pathology Ovarian Neoplasms - surgery Predictive Value of Tests Preoperative Care Retrospective Studies ROC Curve Sensitivity and Specificity Tropical medicine Tumors |
| title | Can Serum CA-125 Levels Predict the Optimal Primary Cytoreduction in Patients with Advanced Ovarian Carcinoma? |
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