Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-Free Survival Rates

Purpose: No study has yet analyzed whether changes in relative expression levels of progesterone receptor (PR) isoforms A and B in human breast tumors have significance in predicting clinical outcome. Human PRs are ligand-activated nuclear transcription factors that mediate progesterone action. Thei...

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Veröffentlicht in:	Clinical cancer research 2004-04, Vol.10 (8), p.2751-2760
Hauptverfasser:	Hopp, Torsten A, Weiss, Heidi L, Hilsenbeck, Susan G, Cui, Yukun, Allred, D Craig, Horwitz, Kathryn B, Fuqua, Suzanne A W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antineoplastic agents Antineoplastic Agents, Hormonal - pharmacology Biological and medical sciences Breast Neoplasms - metabolism Breast Neoplasms - mortality Cell Line, Tumor Disease-Free Survival Female Genes, Dominant Humans Immunoblotting Medical sciences Mice Middle Aged NIH 3T3 Cells Pharmacology. Drug treatments Progesterone - metabolism Proportional Hazards Models Protein Isoforms Receptors, Estrogen - metabolism Receptors, Progesterone - biosynthesis Tamoxifen - pharmacology Time Factors Transcriptional Activation Treatment Outcome Tumors
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