Cellular Immunotherapy for Follicular Lymphoma Using Genetically Modified CD20-Specific CD8+ Cytotoxic T Lymphocytes

Humoral immunotherapy using the monoclonal anti-CD20 antibody rituximab induces remissions in ∼60% of patients with relapsed follicular lymphoma; however, most patients eventually relapse despite continued expression of CD20 on lymphoma cells. We have hypothesized that cellular immunotherapy targeti...

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Veröffentlicht in:	Molecular therapy 2004-04, Vol.9 (4), p.577-586
Hauptverfasser:	Wang, Jinjuan, Press, Oliver W, Lindgren, Catherine G, Greenberg, Philip, Riddell, Stanley, Qian, Xiaojun, Laugen, Christian, Raubitschek, Andrew, Forman, Stephen J, Jensen, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics Antibodies Antigens Antigens, CD20 - biosynthesis Antigens, CD20 - metabolism Blotting, Southern Blotting, Western Cancer research Cancer therapies Caspases - metabolism CD20 CD3 Complex - chemistry CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - metabolism Cell Line, Tumor Cell Membrane - metabolism Cells, Cultured cellular immunotherapy Chromium - metabolism Clinical trials Cloning Cloning, Molecular CTL clones Cytotoxicity Electroporation Experiments Flow Cytometry follicular lymphoma Gene therapy Gene Transfer Techniques Genetic engineering Genetic Therapy - methods Humans Immunoglobulins Immunotherapy Immunotherapy - methods Interleukin-2 - metabolism Kanamycin Kinase - metabolism Lymph Nodes - pathology Lymphocytes Lymphoma Lymphoma - metabolism Lymphoma, Follicular - therapy Medical research Patients Plasmids - metabolism Receptors, Antigen, T-Cell - metabolism Research centers scFvFc:ζ chimeric TCR T cell receptors T-Lymphocytes - metabolism Time Factors Transfection Transgenes
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