Relationship between Insulin Resistance and Muscle Triglyceride Content in Nonobese and Obese Experimental Models of Insulin Resistance Syndrome
: In nonobese hereditary hypertriglyceridemic (HTg) rats and obese HTg Koletsky SHROB/Kol rats, muscle triglyceride accumulation and its relationship to glucose homeostasis and tissue sensitivity to insulin action were examined. Soleus muscle and diaphragm triglyceride contents were markedly increas...
Gespeichert in:
| Veröffentlicht in: | Annals of the New York Academy of Sciences 2002-06, Vol.967 (1), p.440-445 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 445 |
|---|---|
| container_issue | 1 |
| container_start_page | 440 |
| container_title | Annals of the New York Academy of Sciences |
| container_volume | 967 |
| creator | DIVIŠOVÁ, JANA KAZDOVÁ, LUDMILA HUBOVÁ, MIRIAM MESCHIŠVILI, ELEN |
| description | : In nonobese hereditary hypertriglyceridemic (HTg) rats and obese HTg Koletsky SHROB/Kol rats, muscle triglyceride accumulation and its relationship to glucose homeostasis and tissue sensitivity to insulin action were examined. Soleus muscle and diaphragm triglyceride contents were markedly increased in HTg rats as compared with controls and were further increased in obese animals. On the other hand, glucose intolerance and impairment of insulin‐stimulated in vitro glycogen synthesis were of a similar degree in nonobese as well as obese animals. Results indicate that insulin resistance did not increase proportionally to muscle triglyceride content. |
| doi_str_mv | 10.1111/j.1749-6632.2002.tb04300.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71845636</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71845636</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4090-d7a072aa5e0e40df802a5caacb79cec19a66d30059601b137c05f67eeb4f67cc3</originalsourceid><addsrcrecordid>eNqVkUFv0zAYhi0EYmXwF5DFgVuyz4ljJ1zQVm3dpK2TtiHEyXKcL5Di2iVOtPZf8JNxl2pcuODLZ8mPH8vvS8gHBimL62SVMsmrRIg8SzOALB1q4DlAun1BZs9HL8kMQMqkrLL8iLwJYQXAspLL1-SIZSCrUmYz8vsOrR4678KPbkNrHB4RHb1yYbSdo3cYujBoZ5Bq19CbMRiL9KHvvtudwb5rkM69G9ANNNJL73yNYWJvn3bn203E1hHQlt74Bm2gvv2X_37nmt6v8S151Wob8N1hHpMvF-cP88vk-nZxNT-9TgyHCpJGapCZ1gUCcmjaEjJdGK1NLSuDhlVaiCZmUlQCWM1yaaBohUSseRzG5Mfk4-Td9P7XiGFQ6y4YtFY79GNQkpW8ELmI4KcJNL0PocdWbeKPdL9TDNS-D7VS-9DVPnS170Md-lDbePn94ZWxXmPz9-qhgAh8noDHzuLuP9Rq-e30nnOIhmQyxCRx-2zQ_U8lZC4L9XW5UEtxeSHzs4Xi-R-R6K2T</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71845636</pqid></control><display><type>article</type><title>Relationship between Insulin Resistance and Muscle Triglyceride Content in Nonobese and Obese Experimental Models of Insulin Resistance Syndrome</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>DIVIŠOVÁ, JANA ; KAZDOVÁ, LUDMILA ; HUBOVÁ, MIRIAM ; MESCHIŠVILI, ELEN</creator><creatorcontrib>DIVIŠOVÁ, JANA ; KAZDOVÁ, LUDMILA ; HUBOVÁ, MIRIAM ; MESCHIŠVILI, ELEN</creatorcontrib><description>: In nonobese hereditary hypertriglyceridemic (HTg) rats and obese HTg Koletsky SHROB/Kol rats, muscle triglyceride accumulation and its relationship to glucose homeostasis and tissue sensitivity to insulin action were examined. Soleus muscle and diaphragm triglyceride contents were markedly increased in HTg rats as compared with controls and were further increased in obese animals. On the other hand, glucose intolerance and impairment of insulin‐stimulated in vitro glycogen synthesis were of a similar degree in nonobese as well as obese animals. Results indicate that insulin resistance did not increase proportionally to muscle triglyceride content.</description><identifier>ISSN: 0077-8923</identifier><identifier>EISSN: 1749-6632</identifier><identifier>DOI: 10.1111/j.1749-6632.2002.tb04300.x</identifier><identifier>PMID: 12079872</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Disease Models, Animal ; Glucose Tolerance Test ; Insulin Resistance ; insulin sensitivity ; Male ; Muscles - metabolism ; Obesity - metabolism ; Rats ; skeletal muscle ; Species Specificity ; triglycerides ; Triglycerides - metabolism</subject><ispartof>Annals of the New York Academy of Sciences, 2002-06, Vol.967 (1), p.440-445</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4090-d7a072aa5e0e40df802a5caacb79cec19a66d30059601b137c05f67eeb4f67cc3</citedby><cites>FETCH-LOGICAL-c4090-d7a072aa5e0e40df802a5caacb79cec19a66d30059601b137c05f67eeb4f67cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1749-6632.2002.tb04300.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1749-6632.2002.tb04300.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12079872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DIVIŠOVÁ, JANA</creatorcontrib><creatorcontrib>KAZDOVÁ, LUDMILA</creatorcontrib><creatorcontrib>HUBOVÁ, MIRIAM</creatorcontrib><creatorcontrib>MESCHIŠVILI, ELEN</creatorcontrib><title>Relationship between Insulin Resistance and Muscle Triglyceride Content in Nonobese and Obese Experimental Models of Insulin Resistance Syndrome</title><title>Annals of the New York Academy of Sciences</title><addtitle>Ann N Y Acad Sci</addtitle><description>: In nonobese hereditary hypertriglyceridemic (HTg) rats and obese HTg Koletsky SHROB/Kol rats, muscle triglyceride accumulation and its relationship to glucose homeostasis and tissue sensitivity to insulin action were examined. Soleus muscle and diaphragm triglyceride contents were markedly increased in HTg rats as compared with controls and were further increased in obese animals. On the other hand, glucose intolerance and impairment of insulin‐stimulated in vitro glycogen synthesis were of a similar degree in nonobese as well as obese animals. Results indicate that insulin resistance did not increase proportionally to muscle triglyceride content.</description><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Glucose Tolerance Test</subject><subject>Insulin Resistance</subject><subject>insulin sensitivity</subject><subject>Male</subject><subject>Muscles - metabolism</subject><subject>Obesity - metabolism</subject><subject>Rats</subject><subject>skeletal muscle</subject><subject>Species Specificity</subject><subject>triglycerides</subject><subject>Triglycerides - metabolism</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkUFv0zAYhi0EYmXwF5DFgVuyz4ljJ1zQVm3dpK2TtiHEyXKcL5Di2iVOtPZf8JNxl2pcuODLZ8mPH8vvS8gHBimL62SVMsmrRIg8SzOALB1q4DlAun1BZs9HL8kMQMqkrLL8iLwJYQXAspLL1-SIZSCrUmYz8vsOrR4678KPbkNrHB4RHb1yYbSdo3cYujBoZ5Bq19CbMRiL9KHvvtudwb5rkM69G9ANNNJL73yNYWJvn3bn203E1hHQlt74Bm2gvv2X_37nmt6v8S151Wob8N1hHpMvF-cP88vk-nZxNT-9TgyHCpJGapCZ1gUCcmjaEjJdGK1NLSuDhlVaiCZmUlQCWM1yaaBohUSseRzG5Mfk4-Td9P7XiGFQ6y4YtFY79GNQkpW8ELmI4KcJNL0PocdWbeKPdL9TDNS-D7VS-9DVPnS170Md-lDbePn94ZWxXmPz9-qhgAh8noDHzuLuP9Rq-e30nnOIhmQyxCRx-2zQ_U8lZC4L9XW5UEtxeSHzs4Xi-R-R6K2T</recordid><startdate>200206</startdate><enddate>200206</enddate><creator>DIVIŠOVÁ, JANA</creator><creator>KAZDOVÁ, LUDMILA</creator><creator>HUBOVÁ, MIRIAM</creator><creator>MESCHIŠVILI, ELEN</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200206</creationdate><title>Relationship between Insulin Resistance and Muscle Triglyceride Content in Nonobese and Obese Experimental Models of Insulin Resistance Syndrome</title><author>DIVIŠOVÁ, JANA ; KAZDOVÁ, LUDMILA ; HUBOVÁ, MIRIAM ; MESCHIŠVILI, ELEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4090-d7a072aa5e0e40df802a5caacb79cec19a66d30059601b137c05f67eeb4f67cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Glucose Tolerance Test</topic><topic>Insulin Resistance</topic><topic>insulin sensitivity</topic><topic>Male</topic><topic>Muscles - metabolism</topic><topic>Obesity - metabolism</topic><topic>Rats</topic><topic>skeletal muscle</topic><topic>Species Specificity</topic><topic>triglycerides</topic><topic>Triglycerides - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DIVIŠOVÁ, JANA</creatorcontrib><creatorcontrib>KAZDOVÁ, LUDMILA</creatorcontrib><creatorcontrib>HUBOVÁ, MIRIAM</creatorcontrib><creatorcontrib>MESCHIŠVILI, ELEN</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DIVIŠOVÁ, JANA</au><au>KAZDOVÁ, LUDMILA</au><au>HUBOVÁ, MIRIAM</au><au>MESCHIŠVILI, ELEN</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between Insulin Resistance and Muscle Triglyceride Content in Nonobese and Obese Experimental Models of Insulin Resistance Syndrome</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2002-06</date><risdate>2002</risdate><volume>967</volume><issue>1</issue><spage>440</spage><epage>445</epage><pages>440-445</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>: In nonobese hereditary hypertriglyceridemic (HTg) rats and obese HTg Koletsky SHROB/Kol rats, muscle triglyceride accumulation and its relationship to glucose homeostasis and tissue sensitivity to insulin action were examined. Soleus muscle and diaphragm triglyceride contents were markedly increased in HTg rats as compared with controls and were further increased in obese animals. On the other hand, glucose intolerance and impairment of insulin‐stimulated in vitro glycogen synthesis were of a similar degree in nonobese as well as obese animals. Results indicate that insulin resistance did not increase proportionally to muscle triglyceride content.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12079872</pmid><doi>10.1111/j.1749-6632.2002.tb04300.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 2002-06, Vol.967 (1), p.440-445 |
| issn | 0077-8923 1749-6632 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71845636 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Disease Models, Animal Glucose Tolerance Test Insulin Resistance insulin sensitivity Male Muscles - metabolism Obesity - metabolism Rats skeletal muscle Species Specificity triglycerides Triglycerides - metabolism |
| title | Relationship between Insulin Resistance and Muscle Triglyceride Content in Nonobese and Obese Experimental Models of Insulin Resistance Syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T08%3A27%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20between%20Insulin%20Resistance%20and%20Muscle%20Triglyceride%20Content%20in%20Nonobese%20and%20Obese%20Experimental%20Models%20of%20Insulin%20Resistance%20Syndrome&rft.jtitle=Annals%20of%20the%20New%20York%20Academy%20of%20Sciences&rft.au=DIVI%C5%A0OV%C3%81,%20JANA&rft.date=2002-06&rft.volume=967&rft.issue=1&rft.spage=440&rft.epage=445&rft.pages=440-445&rft.issn=0077-8923&rft.eissn=1749-6632&rft_id=info:doi/10.1111/j.1749-6632.2002.tb04300.x&rft_dat=%3Cproquest_cross%3E71845636%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71845636&rft_id=info:pmid/12079872&rfr_iscdi=true |