In-vitro release of fluoropyrimidines from PLGA film implants

The release of two low‐molecular weight water‐soluble fluoropyrimidines, 5‐fluorouracil and 5‐fluorouridine, from implants of PLGA films was modulated by varying the area (diameter) and number of layers of film per implant. The aim was to achieve continuous release without burst effect for at least...

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Veröffentlicht in:	Journal of pharmacy and pharmacology 2002-06, Vol.54 (6), p.757-763
Hauptverfasser:	Dorta, M. Jesús, Oliva, Alexis, Munguía, Obdulia, Llabrés, Matías, Fariña, José B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorbable Implants Analysis of Variance Antineoplastic agents Biological and medical sciences Chromatography, High Pressure Liquid Drug Carriers Drug Implants Fluorouracil - chemistry General aspects General pharmacology Humans Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyglactin 910 - chemistry Uridine - analogs & derivatives Uridine - chemistry
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