Membrane association of estrogen receptor alpha mediates estrogen effect on MAPK activation

Estrogen rapidly activates MAPK in many cell types but the mechanisms have not been fully understood. We previously demonstrated that 17-beta-estradiol (estradiol) rapidly induced membrane translocation of estrogen receptor alpha (ERalpha) and activated MAPK in MCF-7 breast cancer cells. This study...

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Veröffentlicht in:	Biochemical and biophysical research communications 2002-06, Vol.294 (5), p.926-933
Hauptverfasser:	Zhang, Zhenguo, Maier, Bernhard, Santen, Richard J, Song, Robert X-D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - metabolism COS Cells Enzyme Activation Estradiol - pharmacology Estrogen Receptor alpha Mitogen-Activated Protein Kinases - metabolism Phosphorylation Promoter Regions, Genetic Receptors, Estrogen - analysis Receptors, Estrogen - metabolism Response Elements
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