Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor
Clearance of apoptotic cells by macrophages is considered important for prevention of inflammatory responses leading to tissue damage. The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, mediates uptake of apoptotic ce...
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| Veröffentlicht in: | Blood 2004-05, Vol.103 (9), p.3362-3364 |
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| creator | Kunisaki, Yuya Masuko, Sadahiko Noda, Mayuko Inayoshi, Ayumi Sanui, Terukazu Harada, Mine Sasazuki, Takehiko Fukui, Yoshinori |
| description | Clearance of apoptotic cells by macrophages is considered important for prevention of inflammatory responses leading to tissue damage. The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, mediates uptake of apoptotic cells in vitro, yet the physiologic relevance of PSR remains unknown. This issue was addressed by generating PSR-deficient (PSR-/-) mice. PSR-/- mice exhibited severe anemia and died during the perinatal period. In the PSR-/- fetal livers, erythroid differentiation was blocked at an early erythroblast stage. In addition, PSR-/- embryos exhibited thymus atrophy owing to a developmental defect of T-lymphoid cells. Clearance of apoptotic cells by macrophages was impaired in both liver and thymus of PSR-/- embryos. However, this did not induce up-regulation of inflammatory cytokines. These results indicate that during embryonic development, PSR-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses. (Blood. 2004;103:3362-3364) |
| doi_str_mv | 10.1182/blood-2003-09-3245 |
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The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, mediates uptake of apoptotic cells in vitro, yet the physiologic relevance of PSR remains unknown. This issue was addressed by generating PSR-deficient (PSR-/-) mice. PSR-/- mice exhibited severe anemia and died during the perinatal period. In the PSR-/- fetal livers, erythroid differentiation was blocked at an early erythroblast stage. In addition, PSR-/- embryos exhibited thymus atrophy owing to a developmental defect of T-lymphoid cells. Clearance of apoptotic cells by macrophages was impaired in both liver and thymus of PSR-/- embryos. However, this did not induce up-regulation of inflammatory cytokines. These results indicate that during embryonic development, PSR-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses. 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Psychology ; Liver - cytology ; Liver - embryology ; Lymphopoiesis ; Macrophages - immunology ; Macrophages - physiology ; Mice ; Mice, Knockout ; Molecular and cellular biology ; Phenotype ; Receptors, Cell Surface - deficiency ; T-Lymphocytes - cytology ; Thymus Gland - growth & development ; Thymus Gland - pathology</subject><ispartof>Blood, 2004-05, Vol.103 (9), p.3362-3364</ispartof><rights>2004 American Society of Hematology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-d9123907175898291c708d18e154913df15edaa210884a5f47a4b8557455ae33</citedby><cites>FETCH-LOGICAL-c426t-d9123907175898291c708d18e154913df15edaa210884a5f47a4b8557455ae33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15953546$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14715629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kunisaki, Yuya</creatorcontrib><creatorcontrib>Masuko, Sadahiko</creatorcontrib><creatorcontrib>Noda, Mayuko</creatorcontrib><creatorcontrib>Inayoshi, Ayumi</creatorcontrib><creatorcontrib>Sanui, Terukazu</creatorcontrib><creatorcontrib>Harada, Mine</creatorcontrib><creatorcontrib>Sasazuki, Takehiko</creatorcontrib><creatorcontrib>Fukui, Yoshinori</creatorcontrib><title>Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor</title><title>Blood</title><addtitle>Blood</addtitle><description>Clearance of apoptotic cells by macrophages is considered important for prevention of inflammatory responses leading to tissue damage. The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, mediates uptake of apoptotic cells in vitro, yet the physiologic relevance of PSR remains unknown. This issue was addressed by generating PSR-deficient (PSR-/-) mice. PSR-/- mice exhibited severe anemia and died during the perinatal period. In the PSR-/- fetal livers, erythroid differentiation was blocked at an early erythroblast stage. In addition, PSR-/- embryos exhibited thymus atrophy owing to a developmental defect of T-lymphoid cells. Clearance of apoptotic cells by macrophages was impaired in both liver and thymus of PSR-/- embryos. However, this did not induce up-regulation of inflammatory cytokines. These results indicate that during embryonic development, PSR-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses. (Blood. 2004;103:3362-3364)</description><subject>Anemia - etiology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Atrophy</subject><subject>Biological and medical sciences</subject><subject>Cell differentiation, maturation, development, hematopoiesis</subject><subject>Cell physiology</subject><subject>Embryo, Mammalian</subject><subject>Erythropoiesis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Liver - cytology</subject><subject>Liver - embryology</subject><subject>Lymphopoiesis</subject><subject>Macrophages - immunology</subject><subject>Macrophages - physiology</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Molecular and cellular biology</subject><subject>Phenotype</subject><subject>Receptors, Cell Surface - deficiency</subject><subject>T-Lymphocytes - cytology</subject><subject>Thymus Gland - growth & development</subject><subject>Thymus Gland - pathology</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMGOFCEQhonRuLOrL-DBcNFbK0XDNCRezKqrySZe5k4YqLZRummB2WTeXsaZuDdPVan6_krlI-QVsHcAir_fx5R8xxnrO6a7ngv5hGxActUxxtlTsmGMbTuhB7gi16X8ZAxEz-VzcgViALnlekOmTziiq-EB6YjVRhpbmynmY51yWlPAEgq1i6c7Go_zOv2bhYXOwSGN1v0Kyw9aJ6RtXdbJ1uCPsWAOC9KMDtea8gvybLRt-PJSb8juy-fd7dfu_vvdt9uP950TfFs7r4H3mg0wSKUV1-AGpjwoBCk09H4Eid5aDkwpYeUoBiv2SspBSGmx72_I2_PZNaffByzVzKE4jNEumA7FDKAEV0I1kJ9Bl1MpGUez5jDbfDTAzEmv-avXnPQaps1Jbwu9vlw_7Gf0j5GLzwa8uQC2OBvHbBcXyiMnteyl2Dbuw5nDpuIhYDbFBVwc-tCEVeNT-N8ffwD5zZka</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Kunisaki, Yuya</creator><creator>Masuko, Sadahiko</creator><creator>Noda, Mayuko</creator><creator>Inayoshi, Ayumi</creator><creator>Sanui, Terukazu</creator><creator>Harada, Mine</creator><creator>Sasazuki, Takehiko</creator><creator>Fukui, Yoshinori</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor</title><author>Kunisaki, Yuya ; Masuko, Sadahiko ; Noda, Mayuko ; Inayoshi, Ayumi ; Sanui, Terukazu ; Harada, Mine ; Sasazuki, Takehiko ; Fukui, Yoshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-d9123907175898291c708d18e154913df15edaa210884a5f47a4b8557455ae33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Anemia - etiology</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Atrophy</topic><topic>Biological and medical sciences</topic><topic>Cell differentiation, maturation, development, hematopoiesis</topic><topic>Cell physiology</topic><topic>Embryo, Mammalian</topic><topic>Erythropoiesis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Liver - cytology</topic><topic>Liver - embryology</topic><topic>Lymphopoiesis</topic><topic>Macrophages - immunology</topic><topic>Macrophages - physiology</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Molecular and cellular biology</topic><topic>Phenotype</topic><topic>Receptors, Cell Surface - deficiency</topic><topic>T-Lymphocytes - cytology</topic><topic>Thymus Gland - growth & development</topic><topic>Thymus Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kunisaki, Yuya</creatorcontrib><creatorcontrib>Masuko, Sadahiko</creatorcontrib><creatorcontrib>Noda, Mayuko</creatorcontrib><creatorcontrib>Inayoshi, Ayumi</creatorcontrib><creatorcontrib>Sanui, Terukazu</creatorcontrib><creatorcontrib>Harada, Mine</creatorcontrib><creatorcontrib>Sasazuki, Takehiko</creatorcontrib><creatorcontrib>Fukui, Yoshinori</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kunisaki, Yuya</au><au>Masuko, Sadahiko</au><au>Noda, Mayuko</au><au>Inayoshi, Ayumi</au><au>Sanui, Terukazu</au><au>Harada, Mine</au><au>Sasazuki, Takehiko</au><au>Fukui, Yoshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>103</volume><issue>9</issue><spage>3362</spage><epage>3364</epage><pages>3362-3364</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Clearance of apoptotic cells by macrophages is considered important for prevention of inflammatory responses leading to tissue damage. The phosphatidylserine receptor (PSR), which specifically binds to phosphatidylserine (PS) exposed on the surface of apoptotic cells, mediates uptake of apoptotic cells in vitro, yet the physiologic relevance of PSR remains unknown. This issue was addressed by generating PSR-deficient (PSR-/-) mice. PSR-/- mice exhibited severe anemia and died during the perinatal period. In the PSR-/- fetal livers, erythroid differentiation was blocked at an early erythroblast stage. In addition, PSR-/- embryos exhibited thymus atrophy owing to a developmental defect of T-lymphoid cells. Clearance of apoptotic cells by macrophages was impaired in both liver and thymus of PSR-/- embryos. However, this did not induce up-regulation of inflammatory cytokines. These results indicate that during embryonic development, PSR-mediated apoptotic cell uptake is required for definitive erythropoiesis and T lymphopoiesis, independently of the prevention of inflammatory responses. 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| subjects | Anemia - etiology Animals Apoptosis Atrophy Biological and medical sciences Cell differentiation, maturation, development, hematopoiesis Cell physiology Embryo, Mammalian Erythropoiesis Fundamental and applied biological sciences. Psychology Liver - cytology Liver - embryology Lymphopoiesis Macrophages - immunology Macrophages - physiology Mice Mice, Knockout Molecular and cellular biology Phenotype Receptors, Cell Surface - deficiency T-Lymphocytes - cytology Thymus Gland - growth & development Thymus Gland - pathology |
| title | Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor |
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