CD83 on dendritic cells: more than just a marker for maturation
CD83 has been known for a long time to be one of the best markers for mature dendritic cells (DCs). Studies with herpes simplex virus type 1 (HSV-1)-infected DCs, whereby the viral infection leads to the degradation of CD83, as well as investigations inhibiting CD83 mRNA transport, have provided evi...
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| Veröffentlicht in: | Trends in immunology 2002-06, Vol.23 (6), p.273-275 |
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| container_title | Trends in immunology |
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| creator | Lechmann, Matthias Berchtold, Susanne Steinkasserer, Alexander Hauber, Joachim |
| description | CD83 has been known for a long time to be one of the best markers for mature dendritic cells (DCs). Studies with herpes simplex virus type 1 (HSV-1)-infected DCs, whereby the viral infection leads to the degradation of CD83, as well as investigations inhibiting CD83 mRNA transport, have provided evidence that CD83 might also be important for DC biology. Recently, we have shown that the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83.
CD83 is the best known marker for mature dendritic cells. Here, we report the first functional characterization of CD83. |
| doi_str_mv | 10.1016/S1471-4906(02)02214-7 |
| format | Article |
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CD83 is the best known marker for mature dendritic cells. 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| ispartof | Trends in immunology, 2002-06, Vol.23 (6), p.273-275 |
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| subjects | Animals Antigens, CD CD83 CD83 Antigen Cell growth Cytotoxicity dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Eukaryotic Translation Initiation Factor 5A HSV Humans Immune system Immunoglobulins - chemistry Immunoglobulins - physiology Ligands Lymphocyte Activation Lymphocytes Membrane Glycoproteins - chemistry Membrane Glycoproteins - physiology Mice Mice, Knockout Molecular weight Peptide Initiation Factors - metabolism Protein Structure, Tertiary Proteins Recombinant Fusion Proteins - physiology RNA, Messenger - metabolism RNA-Binding Proteins Rodents Simplexvirus - physiology Solubility T cells T-Lymphocyte Subsets - immunology |
| title | CD83 on dendritic cells: more than just a marker for maturation |
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