The natural history of HIV-1 infection in young Thai men after seroconversion
The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2004-05, Vol.36 (1), p.622-629 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | RANGSIN, Ram CHIU, Joseph NELSON, Kenrad E KHAMBOONRUANG, Chirasak SIRISOPANA, Narongrid EIUMTRAKUL, Sakol BROWN, Arthur E ROBB, Merlin BEYRER, Chris RUANGYUTTIKARN, Cholticha MARKOWITZ, Lauri E |
| description | The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4 cell count of |
| doi_str_mv | 10.1097/00126334-200405010-00011 |
| format | Article |
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Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4 cell count of <200/microL was 7.4 years and 6.9 years, respectively. The mortality rate was 56.3 deaths per 1000 patient-years for HIV-positive men and 6.1 deaths per 1000 patient-years for HIV-negative men. Our data suggest a more rapid progression to AIDS and death after HIV-1 infection in young men in Thailand than has been reported for similarly aged cohorts in developed countries.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/00126334-200405010-00011</identifier><identifier>PMID: 15097306</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Acquired Immunodeficiency Syndrome - physiopathology ; Adolescent ; Adult ; AIDS/HIV ; Biological and medical sciences ; CD4 Lymphocyte Count ; Fundamental and applied biological sciences. Psychology ; HIV Seropositivity - mortality ; HIV Seropositivity - physiopathology ; HIV-1 ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; RNA, Viral - blood ; Survival Analysis ; Thailand ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virology</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2004-05, Vol.36 (1), p.622-629</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-2a3930b1793a329b83b17ff3f58e7d58b5ef7f83e4bc5e2e0d3c3962e9d8cef23</citedby><cites>FETCH-LOGICAL-c424t-2a3930b1793a329b83b17ff3f58e7d58b5ef7f83e4bc5e2e0d3c3962e9d8cef23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15705631$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15097306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RANGSIN, Ram</creatorcontrib><creatorcontrib>CHIU, Joseph</creatorcontrib><creatorcontrib>NELSON, Kenrad E</creatorcontrib><creatorcontrib>KHAMBOONRUANG, Chirasak</creatorcontrib><creatorcontrib>SIRISOPANA, Narongrid</creatorcontrib><creatorcontrib>EIUMTRAKUL, Sakol</creatorcontrib><creatorcontrib>BROWN, Arthur E</creatorcontrib><creatorcontrib>ROBB, Merlin</creatorcontrib><creatorcontrib>BEYRER, Chris</creatorcontrib><creatorcontrib>RUANGYUTTIKARN, Cholticha</creatorcontrib><creatorcontrib>MARKOWITZ, Lauri E</creatorcontrib><title>The natural history of HIV-1 infection in young Thai men after seroconversion</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. Nevertheless, valid data are needed to evaluate the effects of interventions, which are designed to delay progression. We evaluated the progression to AIDS and death in 235 men who seroconverted during their 2 years of service in the Royal Thai Army. The men were conscripted at age 21 and seroconverted within a 6-month window during follow-up while in the military. The seroconverters were matched with men who were seronegative when discharged. Of the HIV-positive men, 156 (66.4%) were alive, 77 (32.8%) had died, and 2 (0.8%) could not be located 5-7 years after their seroconversion and discharge from the military. The 5-year survival rate was 82.3%; the median times to clinical AIDS and a CD4 cell count of <200/microL was 7.4 years and 6.9 years, respectively. The mortality rate was 56.3 deaths per 1000 patient-years for HIV-positive men and 6.1 deaths per 1000 patient-years for HIV-negative men. Our data suggest a more rapid progression to AIDS and death after HIV-1 infection in young men in Thailand than has been reported for similarly aged cohorts in developed countries.</description><subject>Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Adolescent</subject><subject>Adult</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV Seropositivity - mortality</subject><subject>HIV Seropositivity - physiopathology</subject><subject>HIV-1</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>RNA, Viral - blood</subject><subject>Survival Analysis</subject><subject>Thailand</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUhi0EoqXwCsgLbAFfE2dEFdBKRSyFNXKcYxqUxMVOkPr2GBouG5N_Wd-5fQhhSq4oybNrQihLORcJI0QQSShJSPyjB2hKcyGSTClxGLNkMhGUywk6CeE1EqkQ-TGaUBm7cJJO0cN6A7jT_eB1gzd16J3fYWfxYvmcUFx3Fkxfuy4mvHND94LXG13jFjqsbQ8eB_DOuO4dfIjYKTqyuglwNr4z9HR3u54vktXj_XJ-s0qMYKJPmOY5JyXNcq45y0vFY7aWW6kgq6QqJdjMKg6iNBIYkIobnqcM8koZsIzP0OW-79a7twFCX7R1MNA0ugM3hCKjSsRbs3_BuIKKIlQE1R403oXgwRZbX7fa7wpKik_nxbfz4sd58eU8lp6PM4ayheq3cJQcgYsR0MHoxnrdmTr84TIiU075B7SEiJU</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>RANGSIN, Ram</creator><creator>CHIU, Joseph</creator><creator>NELSON, Kenrad E</creator><creator>KHAMBOONRUANG, Chirasak</creator><creator>SIRISOPANA, Narongrid</creator><creator>EIUMTRAKUL, Sakol</creator><creator>BROWN, Arthur E</creator><creator>ROBB, Merlin</creator><creator>BEYRER, Chris</creator><creator>RUANGYUTTIKARN, Cholticha</creator><creator>MARKOWITZ, Lauri E</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>The natural history of HIV-1 infection in young Thai men after seroconversion</title><author>RANGSIN, Ram ; CHIU, Joseph ; NELSON, Kenrad E ; KHAMBOONRUANG, Chirasak ; SIRISOPANA, Narongrid ; EIUMTRAKUL, Sakol ; BROWN, Arthur E ; ROBB, Merlin ; BEYRER, Chris ; RUANGYUTTIKARN, Cholticha ; MARKOWITZ, Lauri E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-2a3930b1793a329b83b17ff3f58e7d58b5ef7f83e4bc5e2e0d3c3962e9d8cef23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Adolescent</topic><topic>Adult</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV Seropositivity - mortality</topic><topic>HIV Seropositivity - physiopathology</topic><topic>HIV-1</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>RNA, Viral - blood</topic><topic>Survival Analysis</topic><topic>Thailand</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RANGSIN, Ram</creatorcontrib><creatorcontrib>CHIU, Joseph</creatorcontrib><creatorcontrib>NELSON, Kenrad E</creatorcontrib><creatorcontrib>KHAMBOONRUANG, Chirasak</creatorcontrib><creatorcontrib>SIRISOPANA, Narongrid</creatorcontrib><creatorcontrib>EIUMTRAKUL, Sakol</creatorcontrib><creatorcontrib>BROWN, Arthur E</creatorcontrib><creatorcontrib>ROBB, Merlin</creatorcontrib><creatorcontrib>BEYRER, Chris</creatorcontrib><creatorcontrib>RUANGYUTTIKARN, Cholticha</creatorcontrib><creatorcontrib>MARKOWITZ, Lauri E</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RANGSIN, Ram</au><au>CHIU, Joseph</au><au>NELSON, Kenrad E</au><au>KHAMBOONRUANG, Chirasak</au><au>SIRISOPANA, Narongrid</au><au>EIUMTRAKUL, Sakol</au><au>BROWN, Arthur E</au><au>ROBB, Merlin</au><au>BEYRER, Chris</au><au>RUANGYUTTIKARN, Cholticha</au><au>MARKOWITZ, Lauri E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The natural history of HIV-1 infection in young Thai men after seroconversion</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2004-05-01</date><risdate>2004</risdate><volume>36</volume><issue>1</issue><spage>622</spage><epage>629</epage><pages>622-629</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><abstract>The natural history and progression of HIV-1 infection in Thailand and other developing countries in Asia and Africa have not been well defined. 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Our data suggest a more rapid progression to AIDS and death after HIV-1 infection in young men in Thailand than has been reported for similarly aged cohorts in developed countries.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>15097306</pmid><doi>10.1097/00126334-200405010-00011</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1525-4135 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 2004-05, Vol.36 (1), p.622-629 |
| issn | 1525-4135 1944-7884 |
| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; Journals@Ovid LWW Legacy Archive; Free E- Journals |
| subjects | Acquired Immunodeficiency Syndrome - physiopathology Adolescent Adult AIDS/HIV Biological and medical sciences CD4 Lymphocyte Count Fundamental and applied biological sciences. Psychology HIV Seropositivity - mortality HIV Seropositivity - physiopathology HIV-1 Human immunodeficiency virus Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Miscellaneous RNA, Viral - blood Survival Analysis Thailand Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology |
| title | The natural history of HIV-1 infection in young Thai men after seroconversion |
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