Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung
Background. The relative incidence of adenocarcinoma of the lung is increasing and some patients with lung carcinoma, detected at an early stage, still develop recurrent disease despite complete resection of the tumor. Recently, neuroendocrine differentiation in large cell carcinoma of the lung has...
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| Veröffentlicht in: | The Annals of thoracic surgery 2002-06, Vol.73 (6), p.1732-1735 |
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| container_title | The Annals of thoracic surgery |
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| creator | Hiroshima, Kenzo Iyoda, Akira Shibuya, Kiyoshi Toyozaki, Tetsuya Haga, Yukiko Fujisawa, Takehiko Ohwada, Hidemi |
| description | Background. The relative incidence of adenocarcinoma of the lung is increasing and some patients with lung carcinoma, detected at an early stage, still develop recurrent disease despite complete resection of the tumor. Recently, neuroendocrine differentiation in large cell carcinoma of the lung has been reported to be of prognostic significance. Therefore, we have evaluated the prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung.
Methods. A total of 90 resected specimens of adenocarcinoma of the lung measuring 3 cm or less (T1 N0 M0 or T2 N0 M0) were reviewed histologically and immunohistochemical staining was performed to determine the degree of neuroendocrine differentiation.
Results. Seven adenocarcinomas exhibited neuroendocrine differentiation in 10% or more of tumor cells. The disease-free survival rate for these patients was significantly lower than that of patients with tumors exhibiting neuroendocrine differentiation in less than 10% of tumor cells or with absent neuroendocrine differentiation (
p < 0.0005). Other conventional pathologic factors such as vascular invasion (
p < 0.0005), lymphatic invasion (
p < 0.05), and pleural involvement (
p < 0.05) were also of prognostic significance. In multivariate analysis, the presence of 10% or more neuroendocrine marker-positive tumor cells, vascular invasion, and lymphatic invasion were found to be significantly adverse prognostic factors (
p = 0.0162,
p = 0.0111, and
p = 0.0173, respectively).
Conclusions. Neuroendocrine differentiation of tumor cells is a prognostic factor in lung adenocarcinoma. It is suggested that the identification of neuroendocrine differentiation as well as vascular invasion by tumor in small peripheral adenocarcinoma of the lung may predict the prognosis of these patients. |
| doi_str_mv | 10.1016/S0003-4975(02)03504-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71841448</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S000349750203504X</els_id><sourcerecordid>71841448</sourcerecordid><originalsourceid>FETCH-LOGICAL-c540t-2a5974a77809b71fd592a617acea0939f4a6bc82879d62f62be625c078f4f0c63</originalsourceid><addsrcrecordid>eNqFkF1LHDEUhoNU6mr7EyxzU7EXo0kmH5OrImJbQbBgS70L2czJ9pTZxCYzgv--WXepl16FkOc9581DyDGjZ4wydX5HKe1aYbQ8pfwT7SQV7f0eWTApeau4NG_I4j9yQA5L-VOvvD6_JQeMU91rxRbk1_ecVjGVCX1TcBUxoHfRQ5NCE2HOCeKQfMYIzYAhQIY4oZswxQZj4waIybvsMaa122Sm39CMc1y9I_vBjQXe784j8vPL1Y_Lb-3N7dfry4ub1ktBp5Y7abRwWvfULDULgzTcKaadB0dNZ4Jwaul73mszKB4UX0L9m6_tgwjUq-6InGznPuT0d4Yy2TUWD-PoIqS5WM16wYToKyi3oM-plAzBPmRcu_xkGbUbo_bZqN3ospTbZ6P2vuY-7BbMyzUML6mdwgp83AGueDeGXPVheeE6TQ1TmwKftxxUHY8I2RaPUFUPmMFPdkj4SpV_OA2TkA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71841448</pqid></control><display><type>article</type><title>Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via ScienceDirect (Elsevier)</source><source>Alma/SFX Local Collection</source><creator>Hiroshima, Kenzo ; Iyoda, Akira ; Shibuya, Kiyoshi ; Toyozaki, Tetsuya ; Haga, Yukiko ; Fujisawa, Takehiko ; Ohwada, Hidemi</creator><creatorcontrib>Hiroshima, Kenzo ; Iyoda, Akira ; Shibuya, Kiyoshi ; Toyozaki, Tetsuya ; Haga, Yukiko ; Fujisawa, Takehiko ; Ohwada, Hidemi</creatorcontrib><description>Background. The relative incidence of adenocarcinoma of the lung is increasing and some patients with lung carcinoma, detected at an early stage, still develop recurrent disease despite complete resection of the tumor. Recently, neuroendocrine differentiation in large cell carcinoma of the lung has been reported to be of prognostic significance. Therefore, we have evaluated the prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung.
Methods. A total of 90 resected specimens of adenocarcinoma of the lung measuring 3 cm or less (T1 N0 M0 or T2 N0 M0) were reviewed histologically and immunohistochemical staining was performed to determine the degree of neuroendocrine differentiation.
Results. Seven adenocarcinomas exhibited neuroendocrine differentiation in 10% or more of tumor cells. The disease-free survival rate for these patients was significantly lower than that of patients with tumors exhibiting neuroendocrine differentiation in less than 10% of tumor cells or with absent neuroendocrine differentiation (
p < 0.0005). Other conventional pathologic factors such as vascular invasion (
p < 0.0005), lymphatic invasion (
p < 0.05), and pleural involvement (
p < 0.05) were also of prognostic significance. In multivariate analysis, the presence of 10% or more neuroendocrine marker-positive tumor cells, vascular invasion, and lymphatic invasion were found to be significantly adverse prognostic factors (
p = 0.0162,
p = 0.0111, and
p = 0.0173, respectively).
Conclusions. Neuroendocrine differentiation of tumor cells is a prognostic factor in lung adenocarcinoma. It is suggested that the identification of neuroendocrine differentiation as well as vascular invasion by tumor in small peripheral adenocarcinoma of the lung may predict the prognosis of these patients.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/S0003-4975(02)03504-X</identifier><identifier>PMID: 12078761</identifier><identifier>CODEN: ATHSAK</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenocarcinoma - chemistry ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Aged ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Female ; Humans ; Incidence ; Lung Neoplasms - chemistry ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neurosecretion ; Pneumology ; Prognosis ; Survival Rate ; Tumors of the respiratory system and mediastinum</subject><ispartof>The Annals of thoracic surgery, 2002-06, Vol.73 (6), p.1732-1735</ispartof><rights>2002 The Society of Thoracic Surgeons</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-2a5974a77809b71fd592a617acea0939f4a6bc82879d62f62be625c078f4f0c63</citedby><cites>FETCH-LOGICAL-c540t-2a5974a77809b71fd592a617acea0939f4a6bc82879d62f62be625c078f4f0c63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0003-4975(02)03504-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13709168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12078761$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hiroshima, Kenzo</creatorcontrib><creatorcontrib>Iyoda, Akira</creatorcontrib><creatorcontrib>Shibuya, Kiyoshi</creatorcontrib><creatorcontrib>Toyozaki, Tetsuya</creatorcontrib><creatorcontrib>Haga, Yukiko</creatorcontrib><creatorcontrib>Fujisawa, Takehiko</creatorcontrib><creatorcontrib>Ohwada, Hidemi</creatorcontrib><title>Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background. The relative incidence of adenocarcinoma of the lung is increasing and some patients with lung carcinoma, detected at an early stage, still develop recurrent disease despite complete resection of the tumor. Recently, neuroendocrine differentiation in large cell carcinoma of the lung has been reported to be of prognostic significance. Therefore, we have evaluated the prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung.
Methods. A total of 90 resected specimens of adenocarcinoma of the lung measuring 3 cm or less (T1 N0 M0 or T2 N0 M0) were reviewed histologically and immunohistochemical staining was performed to determine the degree of neuroendocrine differentiation.
Results. Seven adenocarcinomas exhibited neuroendocrine differentiation in 10% or more of tumor cells. The disease-free survival rate for these patients was significantly lower than that of patients with tumors exhibiting neuroendocrine differentiation in less than 10% of tumor cells or with absent neuroendocrine differentiation (
p < 0.0005). Other conventional pathologic factors such as vascular invasion (
p < 0.0005), lymphatic invasion (
p < 0.05), and pleural involvement (
p < 0.05) were also of prognostic significance. In multivariate analysis, the presence of 10% or more neuroendocrine marker-positive tumor cells, vascular invasion, and lymphatic invasion were found to be significantly adverse prognostic factors (
p = 0.0162,
p = 0.0111, and
p = 0.0173, respectively).
Conclusions. Neuroendocrine differentiation of tumor cells is a prognostic factor in lung adenocarcinoma. It is suggested that the identification of neuroendocrine differentiation as well as vascular invasion by tumor in small peripheral adenocarcinoma of the lung may predict the prognosis of these patients.</description><subject>Adenocarcinoma - chemistry</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung Neoplasms - chemistry</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neurosecretion</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LHDEUhoNU6mr7EyxzU7EXo0kmH5OrImJbQbBgS70L2czJ9pTZxCYzgv--WXepl16FkOc9581DyDGjZ4wydX5HKe1aYbQ8pfwT7SQV7f0eWTApeau4NG_I4j9yQA5L-VOvvD6_JQeMU91rxRbk1_ecVjGVCX1TcBUxoHfRQ5NCE2HOCeKQfMYIzYAhQIY4oZswxQZj4waIybvsMaa122Sm39CMc1y9I_vBjQXe784j8vPL1Y_Lb-3N7dfry4ub1ktBp5Y7abRwWvfULDULgzTcKaadB0dNZ4Jwaul73mszKB4UX0L9m6_tgwjUq-6InGznPuT0d4Yy2TUWD-PoIqS5WM16wYToKyi3oM-plAzBPmRcu_xkGbUbo_bZqN3ospTbZ6P2vuY-7BbMyzUML6mdwgp83AGueDeGXPVheeE6TQ1TmwKftxxUHY8I2RaPUFUPmMFPdkj4SpV_OA2TkA</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Hiroshima, Kenzo</creator><creator>Iyoda, Akira</creator><creator>Shibuya, Kiyoshi</creator><creator>Toyozaki, Tetsuya</creator><creator>Haga, Yukiko</creator><creator>Fujisawa, Takehiko</creator><creator>Ohwada, Hidemi</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung</title><author>Hiroshima, Kenzo ; Iyoda, Akira ; Shibuya, Kiyoshi ; Toyozaki, Tetsuya ; Haga, Yukiko ; Fujisawa, Takehiko ; Ohwada, Hidemi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-2a5974a77809b71fd592a617acea0939f4a6bc82879d62f62be625c078f4f0c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adenocarcinoma - chemistry</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung Neoplasms - chemistry</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neurosecretion</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hiroshima, Kenzo</creatorcontrib><creatorcontrib>Iyoda, Akira</creatorcontrib><creatorcontrib>Shibuya, Kiyoshi</creatorcontrib><creatorcontrib>Toyozaki, Tetsuya</creatorcontrib><creatorcontrib>Haga, Yukiko</creatorcontrib><creatorcontrib>Fujisawa, Takehiko</creatorcontrib><creatorcontrib>Ohwada, Hidemi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hiroshima, Kenzo</au><au>Iyoda, Akira</au><au>Shibuya, Kiyoshi</au><au>Toyozaki, Tetsuya</au><au>Haga, Yukiko</au><au>Fujisawa, Takehiko</au><au>Ohwada, Hidemi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>73</volume><issue>6</issue><spage>1732</spage><epage>1735</epage><pages>1732-1735</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><coden>ATHSAK</coden><abstract>Background. The relative incidence of adenocarcinoma of the lung is increasing and some patients with lung carcinoma, detected at an early stage, still develop recurrent disease despite complete resection of the tumor. Recently, neuroendocrine differentiation in large cell carcinoma of the lung has been reported to be of prognostic significance. Therefore, we have evaluated the prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung.
Methods. A total of 90 resected specimens of adenocarcinoma of the lung measuring 3 cm or less (T1 N0 M0 or T2 N0 M0) were reviewed histologically and immunohistochemical staining was performed to determine the degree of neuroendocrine differentiation.
Results. Seven adenocarcinomas exhibited neuroendocrine differentiation in 10% or more of tumor cells. The disease-free survival rate for these patients was significantly lower than that of patients with tumors exhibiting neuroendocrine differentiation in less than 10% of tumor cells or with absent neuroendocrine differentiation (
p < 0.0005). Other conventional pathologic factors such as vascular invasion (
p < 0.0005), lymphatic invasion (
p < 0.05), and pleural involvement (
p < 0.05) were also of prognostic significance. In multivariate analysis, the presence of 10% or more neuroendocrine marker-positive tumor cells, vascular invasion, and lymphatic invasion were found to be significantly adverse prognostic factors (
p = 0.0162,
p = 0.0111, and
p = 0.0173, respectively).
Conclusions. Neuroendocrine differentiation of tumor cells is a prognostic factor in lung adenocarcinoma. It is suggested that the identification of neuroendocrine differentiation as well as vascular invasion by tumor in small peripheral adenocarcinoma of the lung may predict the prognosis of these patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12078761</pmid><doi>10.1016/S0003-4975(02)03504-X</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma - chemistry Adenocarcinoma - mortality Adenocarcinoma - pathology Aged Biological and medical sciences Biomarkers, Tumor - analysis Female Humans Incidence Lung Neoplasms - chemistry Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical sciences Middle Aged Multivariate Analysis Neurosecretion Pneumology Prognosis Survival Rate Tumors of the respiratory system and mediastinum |
| title | Prognostic significance of neuroendocrine differentiation in adenocarcinoma of the lung |
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