Combined association and linkage analysis applied to the APOE locus

Combined association and linkage analysis is a powerful tool for pinpointing functional quantitative traits (QTLs) responsible for regions of significant linkage identified in genome‐wide scans. We applied this technique to apoE plasma levels and the APOEε2/ε3/ε4 polymorphism in two Dutch twin cohor...

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Veröffentlicht in:	Genetic epidemiology 2004-05, Vol.26 (4), p.328-337
Hauptverfasser:	Beekman, Marian, Posthuma, Daniëlle, Heijmans, Bastiaan T., Lakenberg, Nico, Suchiman, H. Eka D., Snieder, Harold, de Knijff, Peter, Frants, Rune R., van Ommen, Gert Jan B., Kluft, Cornelis, Vogler, George P., Slagboom, P. Eline, Boomsma, Dorret I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult apoE level Apolipoprotein E2 Apolipoprotein E3 Apolipoprotein E4 Apolipoproteins E - genetics Biological and medical sciences Chromosomes, Human, Pair 19 Classical genetics, quantitative genetics, hybrids Cohort Studies Female fine-mapping Fundamental and applied biological sciences. Psychology Genetic Linkage Genetics of eukaryotes. Biological and molecular evolution Genotype Human Humans Lod Score Male Methods, theories and miscellaneous Netherlands Polymorphism, Genetic quantitative trait locus Quantitative Trait, Heritable twin pairs
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