Identification of HLA-A0201-Restricted T Cell Epitopes Derived from the Novel Overexpressed Tumor Antigen Calcium-Activated Chloride Channel 2

Vaccination against tumor Ags may become a promising treatment modality especially in cancer types where other therapeutic approaches fail. However, diversity of tumors requires that a multitude of Ags become available. Differential expression in normal vs cancerous tissues, both at the mRNA and the...

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Veröffentlicht in:	The Journal of immunology (1950) 2002-07, Vol.169 (1), p.540-547
Hauptverfasser:	Konopitzky, Renate, Konig, Ulrich, Meyer, Ralf G, Sommergruber, Wolfgang, Wolfel, Thomas, Schweighoffer, Tamas
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Antigen Presentation Antigens, Neoplasm - analysis Antigens, Neoplasm - biosynthesis Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Calcium - metabolism CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Line Chloride Channels - analysis Chloride Channels - biosynthesis Chloride Channels - genetics Chloride Channels - metabolism Coculture Techniques Epitopes, T-Lymphocyte - analysis Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism HLA-A Antigens - analysis HLA-A Antigens - immunology HLA-A Antigens - metabolism HLA-A2 Antigen Humans Oligopeptides - analysis Oligopeptides - immunology Oligopeptides - metabolism Pancreatic Neoplasms - immunology Peptide Fragments - analysis Peptide Fragments - immunology Peptide Fragments - metabolism Protein Binding - immunology
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