Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels
In general, many cases of malignancy-associated hypercalcemia are due to HHM. In patients with humoral hypercalcemia of malignancy (HHM), it has been reported that plasma parathyroid hormone-related protein (PTHrP) and cyclic adenosine monophosphate (cAMP) levels were elevated, while plasma PTH and...
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| Veröffentlicht in: | Metabolism, clinical and experimental clinical and experimental, 2002-07, Vol.51 (7), p.871-875 |
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| creator | Uchimura, Keiko Mokuno, Takehiko Nagasaka, Akio Hayakawa, Nobuki Kato, Taiya Yamazaki, Naho Kobayashi, Takako Nagata, Mutsuko Kotake, Motoko Itoh, Mitsuyasu Tsujimura, Toru Iwase, Katsumi |
| description | In general, many cases of malignancy-associated hypercalcemia are due to HHM. In patients with humoral hypercalcemia of malignancy (HHM), it has been reported that plasma parathyroid hormone-related protein (PTHrP) and cyclic adenosine monophosphate (cAMP) levels were elevated, while plasma PTH and active vitamin D
3 levels were suppressed. Our patient showed hypercalcemia with a concurrent increase in plasma and tumor tissue PTHrP and PTH concentrations and also high cAMP and low 1-25(OH)
2VD
3 levels in the plasma. These data suggest that the hypercalcemia exhibited by our patient was consistent with HHM due to lung cancer and its liver metastasis. Moreover, diagnostic imaging and autopsy findings showed no appreciable lesions of the parathyroid gland. In addition, histopathologic examination of the primary and metastatic tumors revealed the existence of PTH immunohistochemically stained with anti-PTH antibodies, suggesting an ectopic[ndash ]PTH-producing lung tumor. From these data, our patient was diagnosed with a rare case of lung cancer, which produced both ectopic PTH and PTHrP. |
| doi_str_mv | 10.1053/meta.2002.33341 |
| format | Article |
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3 levels were suppressed. Our patient showed hypercalcemia with a concurrent increase in plasma and tumor tissue PTHrP and PTH concentrations and also high cAMP and low 1-25(OH)
2VD
3 levels in the plasma. These data suggest that the hypercalcemia exhibited by our patient was consistent with HHM due to lung cancer and its liver metastasis. Moreover, diagnostic imaging and autopsy findings showed no appreciable lesions of the parathyroid gland. In addition, histopathologic examination of the primary and metastatic tumors revealed the existence of PTH immunohistochemically stained with anti-PTH antibodies, suggesting an ectopic[ndash ]PTH-producing lung tumor. From these data, our patient was diagnosed with a rare case of lung cancer, which produced both ectopic PTH and PTHrP.</description><identifier>ISSN: 0026-0495</identifier><identifier>EISSN: 1532-8600</identifier><identifier>DOI: 10.1053/meta.2002.33341</identifier><identifier>PMID: 12077733</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Calcium - blood ; Carcinoma, Squamous Cell - complications ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - metabolism ; Endocrinopathies ; Fatal Outcome ; General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes ; Humans ; Hypercalcemia - blood ; Hypercalcemia - complications ; Hypercalcemia - diagnosis ; Immunohistochemistry ; Liver - diagnostic imaging ; Liver - pathology ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - metabolism ; Liver Neoplasms - pathology ; Liver Neoplasms - secondary ; Lung - diagnostic imaging ; Lung - pathology ; Lung Neoplasms - complications ; Lung Neoplasms - diagnosis ; Lung Neoplasms - metabolism ; Male ; Medical sciences ; Parathyroid Glands - diagnostic imaging ; Parathyroid Glands - pathology ; Parathyroid Hormone - blood ; Parathyroid Hormone - metabolism ; Parathyroid Hormone-Related Protein ; Pneumology ; Proteins - analysis ; Proteins - metabolism ; Radiography ; Thyroid Gland - diagnostic imaging ; Thyroid Gland - pathology ; Tumors of the respiratory system and mediastinum ; Ultrasonography</subject><ispartof>Metabolism, clinical and experimental, 2002-07, Vol.51 (7), p.871-875</ispartof><rights>2002</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002, Elsevier Science (USA). All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-f07c32760460eeb1a4a0368e43db778ac9a2313e707936d5b66cf15b77ebe6fc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026049502000112$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13794825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12077733$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uchimura, Keiko</creatorcontrib><creatorcontrib>Mokuno, Takehiko</creatorcontrib><creatorcontrib>Nagasaka, Akio</creatorcontrib><creatorcontrib>Hayakawa, Nobuki</creatorcontrib><creatorcontrib>Kato, Taiya</creatorcontrib><creatorcontrib>Yamazaki, Naho</creatorcontrib><creatorcontrib>Kobayashi, Takako</creatorcontrib><creatorcontrib>Nagata, Mutsuko</creatorcontrib><creatorcontrib>Kotake, Motoko</creatorcontrib><creatorcontrib>Itoh, Mitsuyasu</creatorcontrib><creatorcontrib>Tsujimura, Toru</creatorcontrib><creatorcontrib>Iwase, Katsumi</creatorcontrib><title>Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels</title><title>Metabolism, clinical and experimental</title><addtitle>Metabolism</addtitle><description>In general, many cases of malignancy-associated hypercalcemia are due to HHM. In patients with humoral hypercalcemia of malignancy (HHM), it has been reported that plasma parathyroid hormone-related protein (PTHrP) and cyclic adenosine monophosphate (cAMP) levels were elevated, while plasma PTH and active vitamin D
3 levels were suppressed. Our patient showed hypercalcemia with a concurrent increase in plasma and tumor tissue PTHrP and PTH concentrations and also high cAMP and low 1-25(OH)
2VD
3 levels in the plasma. These data suggest that the hypercalcemia exhibited by our patient was consistent with HHM due to lung cancer and its liver metastasis. Moreover, diagnostic imaging and autopsy findings showed no appreciable lesions of the parathyroid gland. In addition, histopathologic examination of the primary and metastatic tumors revealed the existence of PTH immunohistochemically stained with anti-PTH antibodies, suggesting an ectopic[ndash ]PTH-producing lung tumor. From these data, our patient was diagnosed with a rare case of lung cancer, which produced both ectopic PTH and PTHrP.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Calcium - blood</subject><subject>Carcinoma, Squamous Cell - complications</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Endocrinopathies</subject><subject>Fatal Outcome</subject><subject>General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes</subject><subject>Humans</subject><subject>Hypercalcemia - blood</subject><subject>Hypercalcemia - complications</subject><subject>Hypercalcemia - diagnosis</subject><subject>Immunohistochemistry</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - metabolism</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - secondary</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - pathology</subject><subject>Lung Neoplasms - complications</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parathyroid Glands - diagnostic imaging</subject><subject>Parathyroid Glands - pathology</subject><subject>Parathyroid Hormone - blood</subject><subject>Parathyroid Hormone - metabolism</subject><subject>Parathyroid Hormone-Related Protein</subject><subject>Pneumology</subject><subject>Proteins - analysis</subject><subject>Proteins - metabolism</subject><subject>Radiography</subject><subject>Thyroid Gland - diagnostic imaging</subject><subject>Thyroid Gland - pathology</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Ultrasonography</subject><issn>0026-0495</issn><issn>1532-8600</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAURi1ERYfCmh3yBnaZXj9iJ0tUlYc0Ujft2nKcG8YocQbbKcqP4D_j6YzUDYiVrXvPd_04hLxjsGVQi-sJs91yAL4VQkj2gmxYLXjVKICXZFPqqgLZ1pfkdUo_AEDrRr0il4yXnRZiQ37vlvCdOhscRmpTmp23GXv6y-c93a8HjM6ODidvqQ_94kqrW6mbg1tixJDHleKIj0-Zg40279c4-57u5zjNAakNf61XEcdTJs4ZfaBlBo7pDbkY7Jjw7Xm9Ig-fb-9vvla7uy_fbj7tKidB5moA7QTXCqQCxI5ZaUGoBqXou_JC61rLBROoQbdC9XWnlBtYXXrYoRqcuCIfT3PL8T8XTNlMPjkcRxtwXpLRrJHAa_gvyDRIwWtVwOsT6OKcUsTBHKKfbFwNA3NUZY6qzFGVeVJVEu_Po5duwv6ZP7spwIczYFORMMQiyadnTuhWNrwuXHviygfio8dokvNYhPY-osumn_0_L_EHQDuzmQ</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Uchimura, Keiko</creator><creator>Mokuno, Takehiko</creator><creator>Nagasaka, Akio</creator><creator>Hayakawa, Nobuki</creator><creator>Kato, Taiya</creator><creator>Yamazaki, Naho</creator><creator>Kobayashi, Takako</creator><creator>Nagata, Mutsuko</creator><creator>Kotake, Motoko</creator><creator>Itoh, Mitsuyasu</creator><creator>Tsujimura, Toru</creator><creator>Iwase, Katsumi</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels</title><author>Uchimura, Keiko ; Mokuno, Takehiko ; Nagasaka, Akio ; Hayakawa, Nobuki ; Kato, Taiya ; Yamazaki, Naho ; Kobayashi, Takako ; Nagata, Mutsuko ; Kotake, Motoko ; Itoh, Mitsuyasu ; Tsujimura, Toru ; Iwase, Katsumi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-f07c32760460eeb1a4a0368e43db778ac9a2313e707936d5b66cf15b77ebe6fc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Calcium - blood</topic><topic>Carcinoma, Squamous Cell - complications</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Endocrinopathies</topic><topic>Fatal Outcome</topic><topic>General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes</topic><topic>Humans</topic><topic>Hypercalcemia - blood</topic><topic>Hypercalcemia - complications</topic><topic>Hypercalcemia - diagnosis</topic><topic>Immunohistochemistry</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - metabolism</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - secondary</topic><topic>Lung - diagnostic imaging</topic><topic>Lung - pathology</topic><topic>Lung Neoplasms - complications</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Parathyroid Glands - diagnostic imaging</topic><topic>Parathyroid Glands - pathology</topic><topic>Parathyroid Hormone - blood</topic><topic>Parathyroid Hormone - metabolism</topic><topic>Parathyroid Hormone-Related Protein</topic><topic>Pneumology</topic><topic>Proteins - analysis</topic><topic>Proteins - metabolism</topic><topic>Radiography</topic><topic>Thyroid Gland - diagnostic imaging</topic><topic>Thyroid Gland - pathology</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uchimura, Keiko</creatorcontrib><creatorcontrib>Mokuno, Takehiko</creatorcontrib><creatorcontrib>Nagasaka, Akio</creatorcontrib><creatorcontrib>Hayakawa, Nobuki</creatorcontrib><creatorcontrib>Kato, Taiya</creatorcontrib><creatorcontrib>Yamazaki, Naho</creatorcontrib><creatorcontrib>Kobayashi, Takako</creatorcontrib><creatorcontrib>Nagata, Mutsuko</creatorcontrib><creatorcontrib>Kotake, Motoko</creatorcontrib><creatorcontrib>Itoh, Mitsuyasu</creatorcontrib><creatorcontrib>Tsujimura, Toru</creatorcontrib><creatorcontrib>Iwase, Katsumi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Metabolism, clinical and experimental</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uchimura, Keiko</au><au>Mokuno, Takehiko</au><au>Nagasaka, Akio</au><au>Hayakawa, Nobuki</au><au>Kato, Taiya</au><au>Yamazaki, Naho</au><au>Kobayashi, Takako</au><au>Nagata, Mutsuko</au><au>Kotake, Motoko</au><au>Itoh, Mitsuyasu</au><au>Tsujimura, Toru</au><au>Iwase, Katsumi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels</atitle><jtitle>Metabolism, clinical and experimental</jtitle><addtitle>Metabolism</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>51</volume><issue>7</issue><spage>871</spage><epage>875</epage><pages>871-875</pages><issn>0026-0495</issn><eissn>1532-8600</eissn><abstract>In general, many cases of malignancy-associated hypercalcemia are due to HHM. In patients with humoral hypercalcemia of malignancy (HHM), it has been reported that plasma parathyroid hormone-related protein (PTHrP) and cyclic adenosine monophosphate (cAMP) levels were elevated, while plasma PTH and active vitamin D
3 levels were suppressed. Our patient showed hypercalcemia with a concurrent increase in plasma and tumor tissue PTHrP and PTH concentrations and also high cAMP and low 1-25(OH)
2VD
3 levels in the plasma. These data suggest that the hypercalcemia exhibited by our patient was consistent with HHM due to lung cancer and its liver metastasis. Moreover, diagnostic imaging and autopsy findings showed no appreciable lesions of the parathyroid gland. In addition, histopathologic examination of the primary and metastatic tumors revealed the existence of PTH immunohistochemically stained with anti-PTH antibodies, suggesting an ectopic[ndash ]PTH-producing lung tumor. From these data, our patient was diagnosed with a rare case of lung cancer, which produced both ectopic PTH and PTHrP.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12077733</pmid><doi>10.1053/meta.2002.33341</doi><tpages>5</tpages></addata></record> |
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| ispartof | Metabolism, clinical and experimental, 2002-07, Vol.51 (7), p.871-875 |
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| subjects | Aged Biological and medical sciences Calcium - blood Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Endocrinopathies Fatal Outcome General aspects. Associated endocrine diseases. Endocrine paraneoplasic syndromes Humans Hypercalcemia - blood Hypercalcemia - complications Hypercalcemia - diagnosis Immunohistochemistry Liver - diagnostic imaging Liver - pathology Liver Neoplasms - diagnostic imaging Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - secondary Lung - diagnostic imaging Lung - pathology Lung Neoplasms - complications Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Male Medical sciences Parathyroid Glands - diagnostic imaging Parathyroid Glands - pathology Parathyroid Hormone - blood Parathyroid Hormone - metabolism Parathyroid Hormone-Related Protein Pneumology Proteins - analysis Proteins - metabolism Radiography Thyroid Gland - diagnostic imaging Thyroid Gland - pathology Tumors of the respiratory system and mediastinum Ultrasonography |
| title | Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels |
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