Attenuation of renal ischemia-reperfusion injury by FR167653 in dogs

Background. Inflammatory cytokines are known to contribute to ischemia-reperfusion injury. We investigated the effect of FR167653 (FR), a suppressor of interleukin-1β and tumor necrosis factor-α, on ischemia-reperfusion injury of the kidney in dogs. Methods. The left kidney was subjected to ischemia...

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Veröffentlicht in:	Surgery 2002-06, Vol.131 (6), p.654-662
Hauptverfasser:	Kitada, Hidehisa, Sugitani, Atsushi, Yamamoto, Hirofumi, Otomo, Naoki, Okabe, Yasuhiro, Inoue, Shigetaka, Nishiyama, Ken-ichi, Morisaki, Takashi, Tanaka, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Dogs Female Interleukin-1 - antagonists & inhibitors Interleukin-1 - metabolism Ischemia - drug therapy Ischemia - pathology Ischemia - physiopathology Kidney - pathology Kidney - physiopathology Lung - pathology Lung - physiopathology Male Pyrazoles - therapeutic use Pyridines - therapeutic use Renal Circulation - drug effects Reperfusion Injury - drug therapy Reperfusion Injury - pathology Reperfusion Injury - physiopathology Tumor Necrosis Factor-alpha - antagonists & inhibitors
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