Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters
We examined the immunohistochemical expression of aromatase cytochrome P450 (P450arom), estrogen receptor (ER), progesterone receptor (PR), and Ki-67 in postoperative uterine sarcomas ( n=31) and the corresponding eutopic endometria ( n=20) to evaluate the relationships between the endocrine charact...
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| Veröffentlicht in: | The Journal of steroid biochemistry and molecular biology 2004-02, Vol.88 (2), p.183-189 |
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| container_title | The Journal of steroid biochemistry and molecular biology |
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| creator | Kitaoka, Yui Kitawaki, Jo Koshiba, Hisato Inoue, Shigeo Ishihara, Hiroaki Teramoto, Mariko Honjo, Hideo |
| description | We examined the immunohistochemical expression of aromatase cytochrome P450 (P450arom), estrogen receptor (ER), progesterone receptor (PR), and Ki-67 in postoperative uterine sarcomas (
n=31) and the corresponding eutopic endometria (
n=20) to evaluate the relationships between the endocrine character of uterine sarcomas and the clinical features. In sarcoma tissues, P450arom was detected in 55% of cases, ER in 42%, PR in 42%, and Ki-67 in 90%. In eutopic endometria, P450arom was detected in 60% of cases, ER in 60%, and PR in 35%. There were correlations in the steroid-related proteins between the tumors and endometria (
P=0.001–0.026). The positivity of endometrial P450arom (
P=0.04) and ER (
P=0.006) was higher in surviving patients than dead patients regardless of the menstrual state. The results demonstrate correlation between the expression of P450arom, ER, and PR in tumors and eutopic endometria. Intense expression of the steroid-related proteins was associated with better survival. |
| doi_str_mv | 10.1016/j.jsbmb.2003.11.013 |
| format | Article |
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n=31) and the corresponding eutopic endometria (
n=20) to evaluate the relationships between the endocrine character of uterine sarcomas and the clinical features. In sarcoma tissues, P450arom was detected in 55% of cases, ER in 42%, PR in 42%, and Ki-67 in 90%. In eutopic endometria, P450arom was detected in 60% of cases, ER in 60%, and PR in 35%. There were correlations in the steroid-related proteins between the tumors and endometria (
P=0.001–0.026). The positivity of endometrial P450arom (
P=0.04) and ER (
P=0.006) was higher in surviving patients than dead patients regardless of the menstrual state. The results demonstrate correlation between the expression of P450arom, ER, and PR in tumors and eutopic endometria. Intense expression of the steroid-related proteins was associated with better survival.</description><identifier>ISSN: 0960-0760</identifier><identifier>EISSN: 1879-1220</identifier><identifier>DOI: 10.1016/j.jsbmb.2003.11.013</identifier><identifier>PMID: 15084350</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aromatase - metabolism ; Aromatase cytochrome P450 ; Biological and medical sciences ; Estrogen receptor ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunohistochemistry ; Middle Aged ; Progesterone receptor ; Prognosis ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; Sarcoma - enzymology ; Sarcoma - metabolism ; Sarcoma - pathology ; Uterine Neoplasms - enzymology ; Uterine Neoplasms - metabolism ; Uterine Neoplasms - pathology ; Uterine sarcoma ; Vertebrates: endocrinology</subject><ispartof>The Journal of steroid biochemistry and molecular biology, 2004-02, Vol.88 (2), p.183-189</ispartof><rights>2004 Elsevier Ltd</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c385t-32599b899ad67ddc3fe22fa736f451290caaec0e674f42434eb1d0781f1726573</citedby><cites>FETCH-LOGICAL-c385t-32599b899ad67ddc3fe22fa736f451290caaec0e674f42434eb1d0781f1726573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jsbmb.2003.11.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15738400$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15084350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitaoka, Yui</creatorcontrib><creatorcontrib>Kitawaki, Jo</creatorcontrib><creatorcontrib>Koshiba, Hisato</creatorcontrib><creatorcontrib>Inoue, Shigeo</creatorcontrib><creatorcontrib>Ishihara, Hiroaki</creatorcontrib><creatorcontrib>Teramoto, Mariko</creatorcontrib><creatorcontrib>Honjo, Hideo</creatorcontrib><title>Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters</title><title>The Journal of steroid biochemistry and molecular biology</title><addtitle>J Steroid Biochem Mol Biol</addtitle><description>We examined the immunohistochemical expression of aromatase cytochrome P450 (P450arom), estrogen receptor (ER), progesterone receptor (PR), and Ki-67 in postoperative uterine sarcomas (
n=31) and the corresponding eutopic endometria (
n=20) to evaluate the relationships between the endocrine character of uterine sarcomas and the clinical features. In sarcoma tissues, P450arom was detected in 55% of cases, ER in 42%, PR in 42%, and Ki-67 in 90%. In eutopic endometria, P450arom was detected in 60% of cases, ER in 60%, and PR in 35%. There were correlations in the steroid-related proteins between the tumors and endometria (
P=0.001–0.026). The positivity of endometrial P450arom (
P=0.04) and ER (
P=0.006) was higher in surviving patients than dead patients regardless of the menstrual state. The results demonstrate correlation between the expression of P450arom, ER, and PR in tumors and eutopic endometria. Intense expression of the steroid-related proteins was associated with better survival.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aromatase - metabolism</subject><subject>Aromatase cytochrome P450</subject><subject>Biological and medical sciences</subject><subject>Estrogen receptor</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Middle Aged</subject><subject>Progesterone receptor</subject><subject>Prognosis</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Sarcoma - enzymology</subject><subject>Sarcoma - metabolism</subject><subject>Sarcoma - pathology</subject><subject>Uterine Neoplasms - enzymology</subject><subject>Uterine Neoplasms - metabolism</subject><subject>Uterine Neoplasms - pathology</subject><subject>Uterine sarcoma</subject><subject>Vertebrates: endocrinology</subject><issn>0960-0760</issn><issn>1879-1220</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1ERZfCL0BCvsAtYWwncYLEoar4kirRQzlbjjOhXiX24vGCqv55vN2V4MTJntHzjmYexl4JqAWI7t223tK4jrUEULUQNQj1hG1Er4dKSAlP2QaGDirQHZyz50RbKKAS-hk7Fy30jWphwx4uU1xttoTc3efo7kqJ_KZpgdswcaSc4g8Mj8Xu8KWMKQbkCR3uckzEfeD70vSlSTa5Mo7ecxdTwsVmHwP_7fMdd4sP3tmF72yyK5YAvWBns10IX57eC_b908fbqy_V9bfPX68uryun-jZXSrbDMPbDYKdOT5NTM0o5W626uWmFHMBZiw6w083cyEY1OIoJdC9moWXXanXB3h7nlgN-7ssFZvXkcFlswLgno0WvBtW1BVRH0KVIlHA2u-RXm-6NAHNwbrbm0bk5ODdCmOK8pF6fxu_HFae_mZPkArw5AZaKgTnZ4Dz9w2nVN3DgPhw5LDJ-eUyGnMfgcPLFdjZT9P9d5A-T0qJV</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Kitaoka, Yui</creator><creator>Kitawaki, Jo</creator><creator>Koshiba, Hisato</creator><creator>Inoue, Shigeo</creator><creator>Ishihara, Hiroaki</creator><creator>Teramoto, Mariko</creator><creator>Honjo, Hideo</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters</title><author>Kitaoka, Yui ; Kitawaki, Jo ; Koshiba, Hisato ; Inoue, Shigeo ; Ishihara, Hiroaki ; Teramoto, Mariko ; Honjo, Hideo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c385t-32599b899ad67ddc3fe22fa736f451290caaec0e674f42434eb1d0781f1726573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aromatase - metabolism</topic><topic>Aromatase cytochrome P450</topic><topic>Biological and medical sciences</topic><topic>Estrogen receptor</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Middle Aged</topic><topic>Progesterone receptor</topic><topic>Prognosis</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Receptors, Progesterone - metabolism</topic><topic>Sarcoma - enzymology</topic><topic>Sarcoma - metabolism</topic><topic>Sarcoma - pathology</topic><topic>Uterine Neoplasms - enzymology</topic><topic>Uterine Neoplasms - metabolism</topic><topic>Uterine Neoplasms - pathology</topic><topic>Uterine sarcoma</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitaoka, Yui</creatorcontrib><creatorcontrib>Kitawaki, Jo</creatorcontrib><creatorcontrib>Koshiba, Hisato</creatorcontrib><creatorcontrib>Inoue, Shigeo</creatorcontrib><creatorcontrib>Ishihara, Hiroaki</creatorcontrib><creatorcontrib>Teramoto, Mariko</creatorcontrib><creatorcontrib>Honjo, Hideo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitaoka, Yui</au><au>Kitawaki, Jo</au><au>Koshiba, Hisato</au><au>Inoue, Shigeo</au><au>Ishihara, Hiroaki</au><au>Teramoto, Mariko</au><au>Honjo, Hideo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters</atitle><jtitle>The Journal of steroid biochemistry and molecular biology</jtitle><addtitle>J Steroid Biochem Mol Biol</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>88</volume><issue>2</issue><spage>183</spage><epage>189</epage><pages>183-189</pages><issn>0960-0760</issn><eissn>1879-1220</eissn><abstract>We examined the immunohistochemical expression of aromatase cytochrome P450 (P450arom), estrogen receptor (ER), progesterone receptor (PR), and Ki-67 in postoperative uterine sarcomas (
n=31) and the corresponding eutopic endometria (
n=20) to evaluate the relationships between the endocrine character of uterine sarcomas and the clinical features. In sarcoma tissues, P450arom was detected in 55% of cases, ER in 42%, PR in 42%, and Ki-67 in 90%. In eutopic endometria, P450arom was detected in 60% of cases, ER in 60%, and PR in 35%. There were correlations in the steroid-related proteins between the tumors and endometria (
P=0.001–0.026). The positivity of endometrial P450arom (
P=0.04) and ER (
P=0.006) was higher in surviving patients than dead patients regardless of the menstrual state. The results demonstrate correlation between the expression of P450arom, ER, and PR in tumors and eutopic endometria. Intense expression of the steroid-related proteins was associated with better survival.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15084350</pmid><doi>10.1016/j.jsbmb.2003.11.013</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of steroid biochemistry and molecular biology, 2004-02, Vol.88 (2), p.183-189 |
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| subjects | Adult Aged Aged, 80 and over Aromatase - metabolism Aromatase cytochrome P450 Biological and medical sciences Estrogen receptor Female Fundamental and applied biological sciences. Psychology Humans Immunohistochemistry Middle Aged Progesterone receptor Prognosis Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Sarcoma - enzymology Sarcoma - metabolism Sarcoma - pathology Uterine Neoplasms - enzymology Uterine Neoplasms - metabolism Uterine Neoplasms - pathology Uterine sarcoma Vertebrates: endocrinology |
| title | Aromatase cytochrome P450 and estrogen and progesterone receptors in uterine sarcomas: correlation with clinical parameters |
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