Gastric acid and particulate aspiration injury inhibits pulmonary bacterial clearance

OBJECTIVETo establish a model of secondary bacterial pneumonia following gastric aspiration and to identify possible mechanisms involved in the suppressed antibacterial defenses following the initial pulmonary insult. DESIGNA controlled, in vivo laboratory study. SETTINGResearch laboratory of a heal...

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Veröffentlicht in:	Critical care medicine 2004-03, Vol.32 (3), p.747-754
Hauptverfasser:	Rotta, Alexandre T, Shiley, Kevin T, Davidson, Bruce A, Helinski, Jadwiga D, Russo, Thomas A, Knight, Paul R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Cytokines - metabolism Escherichia coli - metabolism Intensive care medicine Male Medical sciences Pneumonia, Aspiration - complications Pneumonia, Aspiration - microbiology Pneumonia, Aspiration - physiopathology Rats Rats, Long-Evans Regression Analysis Respiratory Distress Syndrome, Adult - etiology Respiratory Distress Syndrome, Adult - microbiology Respiratory Distress Syndrome, Adult - physiopathology
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