Comparison between the Cobas Integra immunoassay and high-performance liquid chromatography for therapeutic monitoring of carbamazepine

Objectives: Carbamazepine (CBZ) is metabolized by the cytochrome P450 into carbamazepine-10,11-epoxide (CBZepox), a metabolite with similar pharmacological activity to the parent drug. Recently it has been indicated that most current immunoassays for the determination of CBZ are unable to quantitati...

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Veröffentlicht in:	Clinical biochemistry 2002-05, Vol.35 (3), p.251-254
Hauptverfasser:	Hermida, Jesús, Bóveda, M.Dolores, Vadillo, F.Javier, Tutor, J.Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anticonvulsants - blood Anticonvulsants - pharmacokinetics Carbamazepine - blood Carbamazepine - pharmacokinetics Child Chromatography, High Pressure Liquid - methods Drug Monitoring - methods Female Humans Immunoassay - methods Male Middle Aged Reproducibility of Results Sensitivity and Specificity
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