Anti‐CD30‐scFv‐Fc‐IL‐2 antibody‐cytokine fusion protein that induces resting NK cells to highly efficient cytolysis of Hodgkin's lymphoma derived tumour cells

The pathogenesis of Hodgkin's disease (HD) is associated with the accumulation of functionally anergic T cells in the near vicinity of the malignant Hodgkin/Reed‐Sternberg (H/RS) cell. To stimulate locally the anti‐tumour immunity in Hodgkin's disease, we generated an anti‐CD30‐antibody‐in...

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Veröffentlicht in:	International journal of cancer 2004-06, Vol.110 (3), p.386-394
Hauptverfasser:	Heuser, Claudia, Guhlke, Stefan, Matthies, Alexander, Bender, Hans, Barth, Stefan, Diehl, Volker, Abken, Hinrich, Hombach, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antibody‐cytokine‐fusion protein Antineoplastic agents Biological and medical sciences Blotting, Western Cell Line Cell Line, Tumor Cell Separation Cytokines - chemistry DNA, Complementary - metabolism Dose-Response Relationship, Drug Electrophoresis, Polyacrylamide Gel Hodgkin Disease - metabolism Humans IL‐2 fusion protein Immunoglobulin Fragments - chemistry Immunotherapy Immunotherapy - methods Interleukin-2 - chemistry Interleukin-2 - immunology Interleukin-2 - metabolism Jurkat Cells Ki-1 Antigen - biosynthesis Ki-1 Antigen - metabolism Killer Cells, Natural - metabolism Lymphocytes - metabolism Medical sciences Mice Mice, SCID Microscopy, Fluorescence Models, Genetic Pharmacology. Drug treatments Protein Binding Protein Structure, Tertiary Receptors, Interleukin-2 - metabolism recombinant antibodies Recombinant Fusion Proteins - metabolism scFv T-Lymphocytes - metabolism Tissue Distribution
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