Crystal Structures of Human Bifunctional Enzyme Aminoimidazole-4-carboxamide Ribonucleotide Transformylase/IMP Cyclohydrolase in Complex with Potent Sulfonyl-containing Antifolates

Aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/IMP cyclohydrolase (ATIC) is a bifunctional enzyme with folate-dependent AICAR transformylase and IMP cyclohydrolase activities that catalyzes the last two steps of purine biosynthesis. The AICAR transformylase inhibitors BW1540 and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Biological Chemistry 2004-04, Vol.279 (17), p.18034-18045
Hauptverfasser:	Cheong, Cheom-Gil, Wolan, Dennis W., Greasley, Samantha E., Horton, Patricia A., Beardsley, G. Peter, Wilson, Ian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Anions Binding Sites Catalytic Domain CRYSTAL STRUCTURE Crystallography, X-Ray Electrons Enzyme Inhibitors - pharmacology ENZYMES Humans Hydrogen Bonding Hydroxymethyl and Formyl Transferases - chemistry Kinetics MATERIALS SCIENCE Models, Chemical Models, Molecular Molecular Sequence Data Multienzyme Complexes - chemistry Nucleotide Deaminases - chemistry PARTICLE ACCELERATORS Protein Binding Protein Conformation Sequence Homology, Amino Acid STANFORD LINEAR ACCELERATOR CENTER STANFORD SYNCHROTRON RADIATION LABORATORY Substrate Specificity Sulfonamides - pharmacology SYNCHROTRON RADIATION Tetrahydrofolates - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!