The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behçet’s disease
Objectives: Behçet’s disease is a multisystem disorder characterized by a chronic inflammation including acute attacks and remission periods. Decreased enzyme activity of the antioxidant system and increased levels of free radicals may have important roles in the damage of tissues observed in the di...
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| creator | Örem, Asım Yandi, Y.Emre Vanizor, Birgül Çimşit, Gülseren Uydu, Hüseyin Avni Malkoç, Meltem |
| description | Objectives: Behçet’s disease is a multisystem disorder characterized by a chronic inflammation including acute attacks and remission periods. Decreased enzyme activity of the antioxidant system and increased levels of free radicals may have important roles in the damage of tissues observed in the disease period. In addition, the atherogenic tendency of serum lipid, lipoproteins, lipid peroxidation levels and endothelial dysfunction accompany the above mentioned findings. As a consequence of these events, different degrees of low density lipoprotein (LDL) oxidation occur
in vivo, and then autoantibodies against oxidized-LDL(AuAb-oxLDL) are produced.
Design and methods: Lipids, lipoproteins, lipid hydroperoxide, AuAb-oxLDL, total antioxidant status (TAS), serum-soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor 1 (PAI-1) levels in serum, the activities of antioxidant enzymes including glutathione peroxidase (GSH-Px), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) in erythrocytes and plasma, were determined in 25 patients with Behçet’s disease and in 25 healthy volunteers. Also, susceptibility to copper-induced
in vitro oxidation of LDL by using lag time, a measure of resistance to oxidation, oxidation rate and extent of oxidation, a measure of diene production in both groups, was studied.
Results: It was observed that lipid hydroperoxide and AuAb-oxLDL levels in patients with Behçet’s disease were significantly higher, but erythrocyte SOD, CAT, plasma GSH-Px activities, and TAS were significantly lower than those in healthy subjects. Susceptibility of LDL to oxidation in the patients was found to be increased. Total cholesterol, LDL-C and apo B levels and acute phase reactants were significantly higher, but HDL-C and apo AI levels were significantly lower, in patients when compared to healthy subjects. The levels of AuAb-oxLDL in patients were found to correlate with TAS, total cholesterol, LDL-C, lipid hydroperoxide and erythrocyte SOD activities (r = −0.62,
p < 0.01; r = 0.64,
p < 0.01; r = 0.55,
p < 0.01; r = 0.81,
p < 0.01; r = −0.63,
p < 0.01, respectively). In addition, lipid hydroperoxide levels were found to correlate with total cholesterol, LDL-C and erythrocyte SOD activities (r = 0.45,
p < 0.05; r = 0.45,
p < 0.05; r = −0.46,
p < 0.05, respectively). PAI-1 and sICAM-1 were found to be increased in the patients and correlated with AuAb-oxLDL and lipid hydroperoxide levels (r = 0.56,
p |
| doi_str_mv | 10.1016/S0009-9120(02)00290-4 |
| format | Article |
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in vivo, and then autoantibodies against oxidized-LDL(AuAb-oxLDL) are produced.
Design and methods: Lipids, lipoproteins, lipid hydroperoxide, AuAb-oxLDL, total antioxidant status (TAS), serum-soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor 1 (PAI-1) levels in serum, the activities of antioxidant enzymes including glutathione peroxidase (GSH-Px), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) in erythrocytes and plasma, were determined in 25 patients with Behçet’s disease and in 25 healthy volunteers. Also, susceptibility to copper-induced
in vitro oxidation of LDL by using lag time, a measure of resistance to oxidation, oxidation rate and extent of oxidation, a measure of diene production in both groups, was studied.
Results: It was observed that lipid hydroperoxide and AuAb-oxLDL levels in patients with Behçet’s disease were significantly higher, but erythrocyte SOD, CAT, plasma GSH-Px activities, and TAS were significantly lower than those in healthy subjects. Susceptibility of LDL to oxidation in the patients was found to be increased. Total cholesterol, LDL-C and apo B levels and acute phase reactants were significantly higher, but HDL-C and apo AI levels were significantly lower, in patients when compared to healthy subjects. The levels of AuAb-oxLDL in patients were found to correlate with TAS, total cholesterol, LDL-C, lipid hydroperoxide and erythrocyte SOD activities (r = −0.62,
p < 0.01; r = 0.64,
p < 0.01; r = 0.55,
p < 0.01; r = 0.81,
p < 0.01; r = −0.63,
p < 0.01, respectively). In addition, lipid hydroperoxide levels were found to correlate with total cholesterol, LDL-C and erythrocyte SOD activities (r = 0.45,
p < 0.05; r = 0.45,
p < 0.05; r = −0.46,
p < 0.05, respectively). PAI-1 and sICAM-1 were found to be increased in the patients and correlated with AuAb-oxLDL and lipid hydroperoxide levels (r = 0.56,
p < 0.01; r = 0.67,
p < 0.01 and r = 0.59,
p < 0.01; r = 0.61,
p < 0.01, respectively).
Conclusions: It was concluded that the observed increase of lipid, lipoproteins, lipid hydroperoxide, susceptibility of LDL to oxidation, autoantibodies against ox-LDL levels and decrease of antioxidant enzyme activities and total antioxidant status and increased secretion of endothelial derivated peptides including sICAM and PAI-1, and their interactions may indicate that there is a tendency to atherothrombotic events in patients with Behçet’s disease.]]></description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/S0009-9120(02)00290-4</identifier><identifier>PMID: 12074830</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Antioxidant enzymes ; Antioxidants - metabolism ; Autoantibodies - immunology ; Autoantibodies against oxidized LDL ; Behcet Syndrome - blood ; Behcet Syndrome - immunology ; Behcet Syndrome - metabolism ; Behcet Syndrome - physiopathology ; Behçet’s disease ; Catalase - metabolism ; Endothelial dysfunction ; Endothelium - physiopathology ; Female ; Glutathione Peroxidase - metabolism ; Glutathione Reductase - metabolism ; Humans ; ICAM-1 ; Lipid hydroperoxide ; Lipid Peroxides - blood ; Lipids - blood ; Lipoproteins, LDL - blood ; Lipoproteins, LDL - immunology ; Lipoproteins, LDL - metabolism ; Male ; Middle Aged ; Oxidation-Reduction ; PAI-1 ; Superoxide Dismutase - metabolism ; Susceptibility of LDL to oxidation ; Total antioxidant status</subject><ispartof>Clinical biochemistry, 2002-05, Vol.35 (3), p.217-224</ispartof><rights>2002 The Canadian Society of Clinical Chemists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-486de980932f2c36ae6a385cf66052a7a9783f355ec9415efc0cde6a9c06c0663</citedby><cites>FETCH-LOGICAL-c361t-486de980932f2c36ae6a385cf66052a7a9783f355ec9415efc0cde6a9c06c0663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009912002002904$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12074830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Örem, Asım</creatorcontrib><creatorcontrib>Yandi, Y.Emre</creatorcontrib><creatorcontrib>Vanizor, Birgül</creatorcontrib><creatorcontrib>Çimşit, Gülseren</creatorcontrib><creatorcontrib>Uydu, Hüseyin Avni</creatorcontrib><creatorcontrib>Malkoç, Meltem</creatorcontrib><title>The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behçet’s disease</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description><![CDATA[Objectives: Behçet’s disease is a multisystem disorder characterized by a chronic inflammation including acute attacks and remission periods. Decreased enzyme activity of the antioxidant system and increased levels of free radicals may have important roles in the damage of tissues observed in the disease period. In addition, the atherogenic tendency of serum lipid, lipoproteins, lipid peroxidation levels and endothelial dysfunction accompany the above mentioned findings. As a consequence of these events, different degrees of low density lipoprotein (LDL) oxidation occur
in vivo, and then autoantibodies against oxidized-LDL(AuAb-oxLDL) are produced.
Design and methods: Lipids, lipoproteins, lipid hydroperoxide, AuAb-oxLDL, total antioxidant status (TAS), serum-soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor 1 (PAI-1) levels in serum, the activities of antioxidant enzymes including glutathione peroxidase (GSH-Px), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) in erythrocytes and plasma, were determined in 25 patients with Behçet’s disease and in 25 healthy volunteers. Also, susceptibility to copper-induced
in vitro oxidation of LDL by using lag time, a measure of resistance to oxidation, oxidation rate and extent of oxidation, a measure of diene production in both groups, was studied.
Results: It was observed that lipid hydroperoxide and AuAb-oxLDL levels in patients with Behçet’s disease were significantly higher, but erythrocyte SOD, CAT, plasma GSH-Px activities, and TAS were significantly lower than those in healthy subjects. Susceptibility of LDL to oxidation in the patients was found to be increased. Total cholesterol, LDL-C and apo B levels and acute phase reactants were significantly higher, but HDL-C and apo AI levels were significantly lower, in patients when compared to healthy subjects. The levels of AuAb-oxLDL in patients were found to correlate with TAS, total cholesterol, LDL-C, lipid hydroperoxide and erythrocyte SOD activities (r = −0.62,
p < 0.01; r = 0.64,
p < 0.01; r = 0.55,
p < 0.01; r = 0.81,
p < 0.01; r = −0.63,
p < 0.01, respectively). In addition, lipid hydroperoxide levels were found to correlate with total cholesterol, LDL-C and erythrocyte SOD activities (r = 0.45,
p < 0.05; r = 0.45,
p < 0.05; r = −0.46,
p < 0.05, respectively). PAI-1 and sICAM-1 were found to be increased in the patients and correlated with AuAb-oxLDL and lipid hydroperoxide levels (r = 0.56,
p < 0.01; r = 0.67,
p < 0.01 and r = 0.59,
p < 0.01; r = 0.61,
p < 0.01, respectively).
Conclusions: It was concluded that the observed increase of lipid, lipoproteins, lipid hydroperoxide, susceptibility of LDL to oxidation, autoantibodies against ox-LDL levels and decrease of antioxidant enzyme activities and total antioxidant status and increased secretion of endothelial derivated peptides including sICAM and PAI-1, and their interactions may indicate that there is a tendency to atherothrombotic events in patients with Behçet’s disease.]]></description><subject>Adult</subject><subject>Antioxidant enzymes</subject><subject>Antioxidants - metabolism</subject><subject>Autoantibodies - immunology</subject><subject>Autoantibodies against oxidized LDL</subject><subject>Behcet Syndrome - blood</subject><subject>Behcet Syndrome - immunology</subject><subject>Behcet Syndrome - metabolism</subject><subject>Behcet Syndrome - physiopathology</subject><subject>Behçet’s disease</subject><subject>Catalase - metabolism</subject><subject>Endothelial dysfunction</subject><subject>Endothelium - physiopathology</subject><subject>Female</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Reductase - metabolism</subject><subject>Humans</subject><subject>ICAM-1</subject><subject>Lipid hydroperoxide</subject><subject>Lipid Peroxides - blood</subject><subject>Lipids - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, LDL - immunology</subject><subject>Lipoproteins, LDL - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidation-Reduction</subject><subject>PAI-1</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Susceptibility of LDL to oxidation</subject><subject>Total antioxidant status</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkuO1DAQhgMCMc3AEUBewYzUASfOyysEw1NqiQXD2vLYFdrIsUPs9BBWXIMTcJC5yZyESrp57JAiOS5_9Vf5dyXJg4w-yWhWPf1AKeUpz3J6QvNTSnNO0-JmssqamqU5Z-xWsvqDHCV3Q_iM27xoqjvJEYbqomF0dePx-RYI7KQdZTTeEd8SOUYvXTQXXhsIRH6SxoVI_FejkdmBnUiHR60BTay_TDW4YOJErOl9P_gIxpGTzcvN6ZqEMSjoUcrYmUBxjJPof4t5hwwMYzcnG43FnN7_ku2kB9_DMJNALGDdsMbUKC2Zu1sUXCQhyjjiyb8xcN-mDohU2K6JeIn1IgxO-7gFa1BCT6EdnVrujP322Ay4GMiliVvyArZXPyFef_8RiDYBZIB7ye1W2gD3D-tx8vH1q_Ozt-nm_Zt3Z883qWJVFlO0VwNvKGd5m2NIQiVZU6q2qmiZy1ryumEtK0tQvMhKaBVVGhmuaIVfxY6TR3tddPLLCCGKzqCH1koHfgyizhpW57xGsNyDavAhDNCKfjCdHCaRUTFPiFgmRMzPL2gulgkRBeY9PBQYLzrQf7MOI4HAsz2AhsPOwCCCQm8UaDOAikJ7858SvwA2sdWG</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Örem, Asım</creator><creator>Yandi, Y.Emre</creator><creator>Vanizor, Birgül</creator><creator>Çimşit, Gülseren</creator><creator>Uydu, Hüseyin Avni</creator><creator>Malkoç, Meltem</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behçet’s disease</title><author>Örem, Asım ; Yandi, Y.Emre ; Vanizor, Birgül ; Çimşit, Gülseren ; Uydu, Hüseyin Avni ; Malkoç, Meltem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-486de980932f2c36ae6a385cf66052a7a9783f355ec9415efc0cde6a9c06c0663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Antioxidant enzymes</topic><topic>Antioxidants - metabolism</topic><topic>Autoantibodies - immunology</topic><topic>Autoantibodies against oxidized LDL</topic><topic>Behcet Syndrome - blood</topic><topic>Behcet Syndrome - immunology</topic><topic>Behcet Syndrome - metabolism</topic><topic>Behcet Syndrome - physiopathology</topic><topic>Behçet’s disease</topic><topic>Catalase - metabolism</topic><topic>Endothelial dysfunction</topic><topic>Endothelium - physiopathology</topic><topic>Female</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Reductase - metabolism</topic><topic>Humans</topic><topic>ICAM-1</topic><topic>Lipid hydroperoxide</topic><topic>Lipid Peroxides - blood</topic><topic>Lipids - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, LDL - immunology</topic><topic>Lipoproteins, LDL - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidation-Reduction</topic><topic>PAI-1</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Susceptibility of LDL to oxidation</topic><topic>Total antioxidant status</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Örem, Asım</creatorcontrib><creatorcontrib>Yandi, Y.Emre</creatorcontrib><creatorcontrib>Vanizor, Birgül</creatorcontrib><creatorcontrib>Çimşit, Gülseren</creatorcontrib><creatorcontrib>Uydu, Hüseyin Avni</creatorcontrib><creatorcontrib>Malkoç, Meltem</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Örem, Asım</au><au>Yandi, Y.Emre</au><au>Vanizor, Birgül</au><au>Çimşit, Gülseren</au><au>Uydu, Hüseyin Avni</au><au>Malkoç, Meltem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behçet’s disease</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>35</volume><issue>3</issue><spage>217</spage><epage>224</epage><pages>217-224</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract><![CDATA[Objectives: Behçet’s disease is a multisystem disorder characterized by a chronic inflammation including acute attacks and remission periods. Decreased enzyme activity of the antioxidant system and increased levels of free radicals may have important roles in the damage of tissues observed in the disease period. In addition, the atherogenic tendency of serum lipid, lipoproteins, lipid peroxidation levels and endothelial dysfunction accompany the above mentioned findings. As a consequence of these events, different degrees of low density lipoprotein (LDL) oxidation occur
in vivo, and then autoantibodies against oxidized-LDL(AuAb-oxLDL) are produced.
Design and methods: Lipids, lipoproteins, lipid hydroperoxide, AuAb-oxLDL, total antioxidant status (TAS), serum-soluble intercellular adhesion molecule-1 (sICAM-1), plasminogen activator inhibitor 1 (PAI-1) levels in serum, the activities of antioxidant enzymes including glutathione peroxidase (GSH-Px), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) in erythrocytes and plasma, were determined in 25 patients with Behçet’s disease and in 25 healthy volunteers. Also, susceptibility to copper-induced
in vitro oxidation of LDL by using lag time, a measure of resistance to oxidation, oxidation rate and extent of oxidation, a measure of diene production in both groups, was studied.
Results: It was observed that lipid hydroperoxide and AuAb-oxLDL levels in patients with Behçet’s disease were significantly higher, but erythrocyte SOD, CAT, plasma GSH-Px activities, and TAS were significantly lower than those in healthy subjects. Susceptibility of LDL to oxidation in the patients was found to be increased. Total cholesterol, LDL-C and apo B levels and acute phase reactants were significantly higher, but HDL-C and apo AI levels were significantly lower, in patients when compared to healthy subjects. The levels of AuAb-oxLDL in patients were found to correlate with TAS, total cholesterol, LDL-C, lipid hydroperoxide and erythrocyte SOD activities (r = −0.62,
p < 0.01; r = 0.64,
p < 0.01; r = 0.55,
p < 0.01; r = 0.81,
p < 0.01; r = −0.63,
p < 0.01, respectively). In addition, lipid hydroperoxide levels were found to correlate with total cholesterol, LDL-C and erythrocyte SOD activities (r = 0.45,
p < 0.05; r = 0.45,
p < 0.05; r = −0.46,
p < 0.05, respectively). PAI-1 and sICAM-1 were found to be increased in the patients and correlated with AuAb-oxLDL and lipid hydroperoxide levels (r = 0.56,
p < 0.01; r = 0.67,
p < 0.01 and r = 0.59,
p < 0.01; r = 0.61,
p < 0.01, respectively).
Conclusions: It was concluded that the observed increase of lipid, lipoproteins, lipid hydroperoxide, susceptibility of LDL to oxidation, autoantibodies against ox-LDL levels and decrease of antioxidant enzyme activities and total antioxidant status and increased secretion of endothelial derivated peptides including sICAM and PAI-1, and their interactions may indicate that there is a tendency to atherothrombotic events in patients with Behçet’s disease.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12074830</pmid><doi>10.1016/S0009-9120(02)00290-4</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9120 |
| ispartof | Clinical biochemistry, 2002-05, Vol.35 (3), p.217-224 |
| issn | 0009-9120 1873-2933 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71837297 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antioxidant enzymes Antioxidants - metabolism Autoantibodies - immunology Autoantibodies against oxidized LDL Behcet Syndrome - blood Behcet Syndrome - immunology Behcet Syndrome - metabolism Behcet Syndrome - physiopathology Behçet’s disease Catalase - metabolism Endothelial dysfunction Endothelium - physiopathology Female Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Humans ICAM-1 Lipid hydroperoxide Lipid Peroxides - blood Lipids - blood Lipoproteins, LDL - blood Lipoproteins, LDL - immunology Lipoproteins, LDL - metabolism Male Middle Aged Oxidation-Reduction PAI-1 Superoxide Dismutase - metabolism Susceptibility of LDL to oxidation Total antioxidant status |
| title | The evaluation of autoantibodies against oxidatively modified low-density lipoprotein (LDL), susceptibility of LDL to oxidation, serum lipids and lipid hydroperoxide levels, total antioxidant status, antioxidant enzyme activities, and endothelial dysfunction in patients with Behçet’s disease |
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