Detection of hepatitis B virus YMDD variants using mass spectrometric analysis of oligonucleotide fragments

Mutations in hepatitis B virus (HBV) to lamivudine resistance that arise during prolonged treatment frequently cause amino acid substitutions in the YMDD motif of HBV DNA polymerase. Current methods of detecting such variants are time-consuming, labor intensive, and unsuitable for screening large nu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of hepatology 2004-05, Vol.40 (5), p.837-844
Hauptverfasser:	Pyo Hong, Sun, Keun Kim, Nam, Gyu Hwang, Seong, Jae Chung, Hyun, Kim, Sukjoon, Hee Han, Jin, Tae Kim, Hyung, Sung Rim, Kyu, Seo Kang, Myung, Yoo, Wangdon, Kim, Soo-Ok
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Antiviral Agents - therapeutic use Base Sequence Biological and medical sciences DNA, Viral - chemistry DNA, Viral - genetics DNA-Directed DNA Polymerase - genetics Drug Resistance, Viral - genetics Gastroenterology. Liver. Pancreas. Abdomen Genetic Variation Genotype Genotyping Hepatitis B virus Hepatitis B virus - enzymology Hepatitis B virus - genetics Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Human viral diseases Humans Infectious diseases Lamivudine Lamivudine - therapeutic use Mass spectrometry Medical sciences Molecular Sequence Data Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Viral diseases Viral hepatitis YMDD variant
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!