Differential response of neuronal cells to a fusion protein of ciliary neurotrophic factor/soluble CNTF‐receptor and leukemia inhibitory factor

Ciliary neurotrophic factor (CNTF) displays neurotrophic activities on motor neurons and neural cell populations both in vivo and in vitro. On target cells lacking intrinsic expression of specific receptor α subunits cytokines of the IL‐6 family only act in the presence of their specific agonistic s...

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Veröffentlicht in:	European journal of biochemistry 2002-06, Vol.269 (12), p.3023-3031
Hauptverfasser:	März, Pia, Özbek, Suat, Fischer, Martina, Voltz, Nicole, Otten, Uwe, Rose‐John, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology Cercopithecus aethiops Ciliary Neurotrophic Factor - genetics Ciliary Neurotrophic Factor - pharmacology COS Cells Cytokine Receptor gp130 cytokines differentiation DNA-Binding Proteins - metabolism Leukemia Inhibitory Factor Receptor alpha Subunit Membrane Glycoproteins - metabolism Mice Mitogen-Activated Protein Kinases - metabolism PC12 cells PC12 Cells - drug effects PC12 Cells - metabolism Protein Subunits rat Rats Receptor, Ciliary Neurotrophic Factor - genetics Receptor, Ciliary Neurotrophic Factor - metabolism Receptors, Cytokine - metabolism Receptors, OSM-LIF Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - pharmacology signal transduction STAT3 Transcription Factor Trans-Activators - metabolism Transfection Tumor Cells, Cultured
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