Conversion from cyclosporine a to tacrolimus in pediatric kidney transplant recipients with chronic rejection: Changes in the immune responses

Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection has not been clarified. We studied changes in kidney function, mixed ly...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Transplantation 2004-02, Vol.77 (4), p.532-537
Hauptverfasser: FERRARIS, Jorge R, TAMBUTTI, Monica L, CARDONI, Rita L, PRIGOSHIN, Norma
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Tacrolimus (Tac) has immunosuppressant properties similar to those of cyclosporine A (CsA), but it is more potent. At present, however, its immunosuppressive activity in renal transplant recipients with ongoing chronic rejection has not been clarified. We studied changes in kidney function, mixed lymphocyte culture, cell-mediated lympholysis, cytotoxic antibodies, lymphocyte population, and cytokine response before and after the conversion from CsA to Tac in 14 pediatric renal transplant recipients with chronic rejection. CsA (5.9+/-0.2 mg/kg/d) was replaced by Tac (0.1+/-0.004 mg/kg/d). Serum creatinine decreased (2.3+/-0.2-1.9+/-0.2 mg/dL, P
ISSN:0041-1337
1534-6080
DOI:10.1097/01.TP.0000112438.46472.38