Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis

In the current studies we generated transgenic mice that overexpress human Insig-1 in the liver under a constitutive promoter. In cultured cells Insig-1 and Insig-2 have been shown to block lipid synthesis in a cholesterol-dependent fashion by inhibiting proteolytic processing of sterol regulatory e...

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Veröffentlicht in:	The Journal of clinical investigation 2004-04, Vol.113 (8), p.1168-1175
Hauptverfasser:	Engelking, Luke J, Kuriyama, Hiroshi, Hammer, Robert E, Horton, Jay D, Brown, Michael S, Goldstein, Joseph L, Liang, Guosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Body fat CCAAT-Enhancer-Binding Proteins - genetics CCAAT-Enhancer-Binding Proteins - metabolism Cholesterol DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Fatty acids Humans Insulin Insulin - pharmacology Intracellular Signaling Peptides and Proteins Kidneys Lipids Lipids - biosynthesis Liver Liver - metabolism Membrane Proteins - physiology Mice Mice, Inbred C57BL Mice, Transgenic Proteins RNA, Messenger - analysis Sterol Regulatory Element Binding Protein 1 Sterols Transcription Factors Transgenic animals Triglycerides Triglycerides - blood
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