Clinical transplantation tolerance: The promise and challenges
Clinical transplantation tolerance: The promise and challenges. Organ transplantation is now well established as a preferred option for the treatment of end-stage organ failure. However, there is a severe shortage of donor organs and continued loss of a significant number of organ grafts due to chro...
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| Veröffentlicht in: | Kidney international 2004-05, Vol.65 (5), p.1560-1563 |
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| creator | Ansari, Mohammed Javeed I. Sayegh, Mohamed H. |
| description | Clinical transplantation tolerance: The promise and challenges. Organ transplantation is now well established as a preferred option for the treatment of end-stage organ failure. However, there is a severe shortage of donor organs and continued loss of a significant number of organ grafts due to chronic allograft dysfunction. Induction of tolerance of a transplant recipient toward their foreign organ graft, therefore, remains the “Holy Grail” of transplantation immunobiologists. Recently, clinical trials to explore pilot tolerance protocols in humans have been initiated. Defining the ideal strategy(ies) and the role of immunosuppressive drugs, developing tolerance assay(s), and enhancing cooperation between transplant professionals, industry, and the government are some of the challenges to achieving clinical transplantation tolerance. This article reviews the promise and the challenges of achieving clinical transplantation tolerance in human organ transplant recipients. |
| doi_str_mv | 10.1111/j.1523-1755.2004.05411.x |
| format | Article |
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Organ transplantation is now well established as a preferred option for the treatment of end-stage organ failure. However, there is a severe shortage of donor organs and continued loss of a significant number of organ grafts due to chronic allograft dysfunction. Induction of tolerance of a transplant recipient toward their foreign organ graft, therefore, remains the “Holy Grail” of transplantation immunobiologists. Recently, clinical trials to explore pilot tolerance protocols in humans have been initiated. Defining the ideal strategy(ies) and the role of immunosuppressive drugs, developing tolerance assay(s), and enhancing cooperation between transplant professionals, industry, and the government are some of the challenges to achieving clinical transplantation tolerance. 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Organ transplantation is now well established as a preferred option for the treatment of end-stage organ failure. However, there is a severe shortage of donor organs and continued loss of a significant number of organ grafts due to chronic allograft dysfunction. Induction of tolerance of a transplant recipient toward their foreign organ graft, therefore, remains the “Holy Grail” of transplantation immunobiologists. Recently, clinical trials to explore pilot tolerance protocols in humans have been initiated. Defining the ideal strategy(ies) and the role of immunosuppressive drugs, developing tolerance assay(s), and enhancing cooperation between transplant professionals, industry, and the government are some of the challenges to achieving clinical transplantation tolerance. This article reviews the promise and the challenges of achieving clinical transplantation tolerance in human organ transplant recipients.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Humans</subject><subject>Immune Tolerance</subject><subject>Immune Tolerance Network (ITN)</subject><subject>islet</subject><subject>Isoantigens</subject><subject>kidney</subject><subject>Kidney Transplantation - immunology</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>organ</subject><subject>T-Lymphocytes - immunology</subject><subject>tolerance</subject><subject>tolerance assays</subject><subject>tolerance trials</subject><subject>transplantation</subject><subject>Transplantation Immunology</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkFFr2zAQx8XYWNJ0X2GYwvpmVydZtryHQRvarlDYS_oszvJ5UXDsVHJK--0rN2Ede5lepDv97vjzYywBnkE8F5sMlJAplEplgvM84yoHyJ4_sPmfj49szrlWqVBSz9hJCBse60ryz2wGiutCV2LOfiw71zuLXTJ67MOuw37E0Q19Mg4dxZal78lqTcnOD1sXKMG-Sewau4763xRO2acWu0BfjveCPdxcr5Y_0_tft3fLy_vU5mU5pojW1mXBUem2qGudS7RYQSWkalorUVFTTQ9b6tYiWKiLqhYlb3JALrGVC3Z-2BtjPO4pjCaGsdTFuDTsgylBS6lFEcGzf8DNsPd9zGYEcABZ5DJC-gBZP4TgqTU777boXwxwMwk2GzN5NJNHMwk2b4LNcxz9ety_r7fUvA8ejUbg2xHAELW2k0IX_uJK4EJVkbs6cBS1PTnyJlhHUXfjPNnRNIP7f5pXMBOZng</recordid><startdate>20040501</startdate><enddate>20040501</enddate><creator>Ansari, Mohammed Javeed I.</creator><creator>Sayegh, Mohamed H.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20040501</creationdate><title>Clinical transplantation tolerance: The promise and challenges</title><author>Ansari, Mohammed Javeed I. ; Sayegh, Mohamed H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-aaccb760a58f6bb843aca919235dfc3a5ed9dfc3c78fca1c1b69b270d41a03af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Humans</topic><topic>Immune Tolerance</topic><topic>Immune Tolerance Network (ITN)</topic><topic>islet</topic><topic>Isoantigens</topic><topic>kidney</topic><topic>Kidney Transplantation - immunology</topic><topic>Medical sciences</topic><topic>Nephrology. 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Organ transplantation is now well established as a preferred option for the treatment of end-stage organ failure. However, there is a severe shortage of donor organs and continued loss of a significant number of organ grafts due to chronic allograft dysfunction. Induction of tolerance of a transplant recipient toward their foreign organ graft, therefore, remains the “Holy Grail” of transplantation immunobiologists. Recently, clinical trials to explore pilot tolerance protocols in humans have been initiated. Defining the ideal strategy(ies) and the role of immunosuppressive drugs, developing tolerance assay(s), and enhancing cooperation between transplant professionals, industry, and the government are some of the challenges to achieving clinical transplantation tolerance. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Humans Immune Tolerance Immune Tolerance Network (ITN) islet Isoantigens kidney Kidney Transplantation - immunology Medical sciences Nephrology. Urinary tract diseases organ T-Lymphocytes - immunology tolerance tolerance assays tolerance trials transplantation Transplantation Immunology |
| title | Clinical transplantation tolerance: The promise and challenges |
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