Novel pyrazolopyrimidine derivatives as GSK-3 inhibitors

A series of [1-aryl-1H-pyrazolo[3,4-d]pyrimidin-4-yl]arylhydrazones were discovered as novel inhibitors glycogen synthase kinase-3 (GSK-3). Based on initial modeling a detailed SAR was constructed. Modification of the interior binding aryl ring (Ar(1)) determined this to be a tight binding region wi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2004-05, Vol.14 (9), p.2121-2125
Hauptverfasser:	PEAT, Andrew J, BOUCHERON, Joyce A, WANG, Tony Y, ZHOU, Huiqiang Q, THOMSON, Stephen A, DICKERSON, Scott H, GARRIDO, Dulce, MILLS, Wendy, PECKHAM, Jennifer, PREUGSCHAT, Frank, SMALLEY, Terrence, SCHWEIKER, Stephanie L, WILSON, Jayme R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glycogen Synthase Kinase 3 - antagonists & inhibitors Medical sciences Miscellaneous Models, Molecular Pharmacology. Drug treatments Pyrazoles - chemistry Pyrimidines - chemistry Pyrimidines - pharmacology
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