Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery
Aims Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes i...
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| Veröffentlicht in: | European heart journal 2002-06, Vol.23 (12), p.953-959 |
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| creator | Cotton, J.M. Mathur, A. Hong, Y. Brown, A.S. Martin, J.F. Erusalimsky, J.D. |
| description | Aims Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interleukin-6 (IL-6). Methods and Results Plasma VEGF-A and IL-6 were measured prior to and at various time intervals following surgery in individuals with angiographically normal coronary arteries requiring cardiac valve replacement (N group) and in patients with coronary artery disease and stable angina undergoing coronary artery bypass grafting (CAD group). Baseline VEGF-A levels were not significantly different in CAD (22·3±2·6pg.ml−1) compared to the N group (14·9±2·9pg.ml−1). Following cardiac surgery there was a significant rise of VEGF-A in CAD (P |
| doi_str_mv | 10.1053/euhj.2001.3034 |
| format | Article |
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Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interleukin-6 (IL-6). Methods and Results Plasma VEGF-A and IL-6 were measured prior to and at various time intervals following surgery in individuals with angiographically normal coronary arteries requiring cardiac valve replacement (N group) and in patients with coronary artery disease and stable angina undergoing coronary artery bypass grafting (CAD group). Baseline VEGF-A levels were not significantly different in CAD (22·3±2·6pg.ml−1) compared to the N group (14·9±2·9pg.ml−1). Following cardiac surgery there was a significant rise of VEGF-A in CAD (P<0·0005 vs baseline), but not in the N group, reaching a maximum (∼2 fold increase) after 24h. Surgery caused a rapid increase of plasma IL-6 in both groups, but the rise was significantly larger in CAD patients (P<0·0005 vs N) where it preceded the increase in VEGF-A. Furthermore, in patients with CAD there was a significant correlation between the change in VEGF-A and the change in IL-6 (P<0·04). Conclusion These findings demonstrate that in patients with coronary artery disease cardiothoracic surgery leads to an acute rise in VEGF-A. We suggest that this rise may result from an interaction between the pre-existing atheromatous process and a systemic increase of inflammatory mediators.</description><identifier>ISSN: 0195-668X</identifier><identifier>EISSN: 1522-9645</identifier><identifier>DOI: 10.1053/euhj.2001.3034</identifier><identifier>PMID: 12069450</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Aged ; Atherosclerosis ; Biological and medical sciences ; Biomarkers - blood ; Cardiac Surgical Procedures ; Cardiology. Vascular system ; cardiovascular surgery ; Coronary Artery Disease - blood ; Coronary Artery Disease - surgery ; Coronary heart disease ; cytokines ; Endothelial Growth Factors - blood ; Female ; growth factors ; Heart ; human ; Humans ; Interleukin-6 - blood ; Male ; Medical sciences ; Middle Aged ; P-Selectin - biosynthesis ; P-Selectin - blood ; Postoperative Period ; Vascular Endothelial Growth Factor A</subject><ispartof>European heart journal, 2002-06, Vol.23 (12), p.953-959</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright 2001 The European Society of Cardiology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-15d0f7d8448b54d07be576d3a99e5d487724e85aaf346075169470b338bbe74b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13734825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12069450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cotton, J.M.</creatorcontrib><creatorcontrib>Mathur, A.</creatorcontrib><creatorcontrib>Hong, Y.</creatorcontrib><creatorcontrib>Brown, A.S.</creatorcontrib><creatorcontrib>Martin, J.F.</creatorcontrib><creatorcontrib>Erusalimsky, J.D.</creatorcontrib><title>Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>Aims Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interleukin-6 (IL-6). Methods and Results Plasma VEGF-A and IL-6 were measured prior to and at various time intervals following surgery in individuals with angiographically normal coronary arteries requiring cardiac valve replacement (N group) and in patients with coronary artery disease and stable angina undergoing coronary artery bypass grafting (CAD group). Baseline VEGF-A levels were not significantly different in CAD (22·3±2·6pg.ml−1) compared to the N group (14·9±2·9pg.ml−1). Following cardiac surgery there was a significant rise of VEGF-A in CAD (P<0·0005 vs baseline), but not in the N group, reaching a maximum (∼2 fold increase) after 24h. Surgery caused a rapid increase of plasma IL-6 in both groups, but the rise was significantly larger in CAD patients (P<0·0005 vs N) where it preceded the increase in VEGF-A. Furthermore, in patients with CAD there was a significant correlation between the change in VEGF-A and the change in IL-6 (P<0·04). Conclusion These findings demonstrate that in patients with coronary artery disease cardiothoracic surgery leads to an acute rise in VEGF-A. We suggest that this rise may result from an interaction between the pre-existing atheromatous process and a systemic increase of inflammatory mediators.</description><subject>Aged</subject><subject>Atherosclerosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiac Surgical Procedures</subject><subject>Cardiology. Vascular system</subject><subject>cardiovascular surgery</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - surgery</subject><subject>Coronary heart disease</subject><subject>cytokines</subject><subject>Endothelial Growth Factors - blood</subject><subject>Female</subject><subject>growth factors</subject><subject>Heart</subject><subject>human</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>P-Selectin - biosynthesis</subject><subject>P-Selectin - blood</subject><subject>Postoperative Period</subject><subject>Vascular Endothelial Growth Factor A</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtuEzEUQC1ERdPCliXyBnaT2uPnLEPVUqSibkBU3Vge25O4OONgewj8QT-7HiWiq2vpHh_pHgDeY7TEiJELN20ely1CeEkQoa_AArO2bTpO2WuwQLhjDefy_hSc5fyIEJIc8zfgFLeId5ShBXhamak4mHx2MA7Q-GSmoIsf1_CPzvM7QTfaWDYueB3gOsV92cBBmxJTs4J-hLuKu7FkuPd1Y2KKo07_oE7F1WGrWVf5EEOI-9lrdLK-CmPSxhuYp7Su4FtwMuiQ3bvjPAc_rq--X940t3dfvl6ubhtDuq40mFk0CCsplT2jFoneMcEt0V3nmKVSiJY6ybQeCOVIMFzvFKgnRPa9E7Qn5-DTwbtL8ffkclFbn40LQY8uTlkJLAlBmFZweQBNijknN6hd8tt6mcJIze3V3F7N7dXcvn74cDRP_dbZF_wYuwIfj0Atq8OQ9Gh8fuGIIFS2rHLNgfO5uL__9zr9UlwQwdTN_YNqxfXn7ue3B8XIM94Pnw0</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Cotton, J.M.</creator><creator>Mathur, A.</creator><creator>Hong, Y.</creator><creator>Brown, A.S.</creator><creator>Martin, J.F.</creator><creator>Erusalimsky, J.D.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery</title><author>Cotton, J.M. ; Mathur, A. ; Hong, Y. ; Brown, A.S. ; Martin, J.F. ; Erusalimsky, J.D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-15d0f7d8448b54d07be576d3a99e5d487724e85aaf346075169470b338bbe74b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aged</topic><topic>Atherosclerosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiac Surgical Procedures</topic><topic>Cardiology. Vascular system</topic><topic>cardiovascular surgery</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - surgery</topic><topic>Coronary heart disease</topic><topic>cytokines</topic><topic>Endothelial Growth Factors - blood</topic><topic>Female</topic><topic>growth factors</topic><topic>Heart</topic><topic>human</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>P-Selectin - biosynthesis</topic><topic>P-Selectin - blood</topic><topic>Postoperative Period</topic><topic>Vascular Endothelial Growth Factor A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cotton, J.M.</creatorcontrib><creatorcontrib>Mathur, A.</creatorcontrib><creatorcontrib>Hong, Y.</creatorcontrib><creatorcontrib>Brown, A.S.</creatorcontrib><creatorcontrib>Martin, J.F.</creatorcontrib><creatorcontrib>Erusalimsky, J.D.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cotton, J.M.</au><au>Mathur, A.</au><au>Hong, Y.</au><au>Brown, A.S.</au><au>Martin, J.F.</au><au>Erusalimsky, J.D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>23</volume><issue>12</issue><spage>953</spage><epage>959</epage><pages>953-959</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>Aims Vascular endothelial growth factor-A (VEGF-A) is an angiogenic and vasoprotective molecule whose expression is modulated by hypoxia and inflammatory mediators. Here we have tested the hypothesis that plasma levels of VEGF-A are influenced by pre-existing coronary artery disease and by changes in circulating interleukin-6 (IL-6). Methods and Results Plasma VEGF-A and IL-6 were measured prior to and at various time intervals following surgery in individuals with angiographically normal coronary arteries requiring cardiac valve replacement (N group) and in patients with coronary artery disease and stable angina undergoing coronary artery bypass grafting (CAD group). Baseline VEGF-A levels were not significantly different in CAD (22·3±2·6pg.ml−1) compared to the N group (14·9±2·9pg.ml−1). Following cardiac surgery there was a significant rise of VEGF-A in CAD (P<0·0005 vs baseline), but not in the N group, reaching a maximum (∼2 fold increase) after 24h. Surgery caused a rapid increase of plasma IL-6 in both groups, but the rise was significantly larger in CAD patients (P<0·0005 vs N) where it preceded the increase in VEGF-A. Furthermore, in patients with CAD there was a significant correlation between the change in VEGF-A and the change in IL-6 (P<0·04). Conclusion These findings demonstrate that in patients with coronary artery disease cardiothoracic surgery leads to an acute rise in VEGF-A. We suggest that this rise may result from an interaction between the pre-existing atheromatous process and a systemic increase of inflammatory mediators.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12069450</pmid><doi>10.1053/euhj.2001.3034</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Atherosclerosis Biological and medical sciences Biomarkers - blood Cardiac Surgical Procedures Cardiology. Vascular system cardiovascular surgery Coronary Artery Disease - blood Coronary Artery Disease - surgery Coronary heart disease cytokines Endothelial Growth Factors - blood Female growth factors Heart human Humans Interleukin-6 - blood Male Medical sciences Middle Aged P-Selectin - biosynthesis P-Selectin - blood Postoperative Period Vascular Endothelial Growth Factor A |
| title | Acute rise of circulating vascular endothelial growth factor-A in patients with coronary artery disease following cardiothoracic surgery |
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