Reduced expression of brain-derived neurotrophic factor in mice deficient for pituitary adenylate cyclase activating polypeptide type-I-receptor

In vitro pituitary adenylate cyclase activating polypeptide (PACAP) induces the expression of brain-derived neurotrophic factor (BDNF) via its specific receptor PAC1. Since BDNF has been implicated in learning paradigms and mice lacking functional PAC1 have deficits in hippocampus-dependent associat...

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Veröffentlicht in:	Neuroscience letters 2004-04, Vol.360 (1), p.106-108
Hauptverfasser:	Zink, Mathias, Otto, Christiane, Zörner, Björn, Zacher, Christiane, Schütz, Günther, Henn, Fritz A., Gass, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - biosynthesis Brain-Derived Neurotrophic Factor - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation - physiology Hippocampus - metabolism In situ-hybridization Male Mice Mice, Inbred C57BL Mice, Transgenic PACAP-type-I-receptor Pilot Projects Pituitary adenylate cyclase activating polypeptide (PACAP) Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I Receptors, Pituitary Hormone - deficiency Receptors, Pituitary Hormone - genetics Vertebrates: nervous system and sense organs
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