The MICA-A4 triplet repeats polymorphism in the transmembrane region confers additional risk for development of psoriatic arthritis in the Croatian population
Summary The aim of this study was to investigate possible differences in the frequencies of alleles at the HLA loci and at microsatellite loci within the HLA region among patients suffering from psoriatic arthritis (PsA) and healthy controls. Fifty‐eight Croatian PsA patients (28 male and 30 female)...
Gespeichert in:
| Veröffentlicht in: | European journal of immunogenetics 2004-04, Vol.31 (2), p.93-98 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 98 |
|---|---|
| container_issue | 2 |
| container_start_page | 93 |
| container_title | European journal of immunogenetics |
| container_volume | 31 |
| creator | Grubi, Z Peri, P Eeeuk-Jelici, E Unec, R Stingl, K Urkovi, B Kerhin-Brkljaci, V |
| description | Summary
The aim of this study was to investigate possible differences in the frequencies of alleles at the HLA loci and at microsatellite loci within the HLA region among patients suffering from psoriatic arthritis (PsA) and healthy controls. Fifty‐eight Croatian PsA patients (28 male and 30 female) and 157 healthy unrelated controls were typed for HLA alleles (A, B, Cw and DRB1) by the polymerase chain reaction–sequence‐specific primers (PCR‐SSP) method, while microsatellite alleles (D6S265, D6S273, MHC class I chain‐related gene (MICA) and MIB) were analysed by electrophoresis in an ALFexpress sequencer (Pharmacia Biotech, Uppsala, Sweden). The findings from this study were: (1) the frequencies of B*39 and B*57 were significantly increased in PsA patients; (2) differences in the frequencies of B*13 and B*27 were not statistically significant after correction; (3) the B*0702, B*18, and B*38 alleles were decreased in patients only before correction; (4) none of the alleles at other HLA loci tested were associated with PsA in Croatia; (5) polymorphism at D6S265, D6S273, and MIB microsatellites in patients did not show any statistically significant differences when compared to controls; (6) the increase in the MICA‐A4 allele frequency in PsA patients was independent of the B*39 and B*57 alleles. |
| doi_str_mv | 10.1111/j.1365-2370.2004.00452.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71832710</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71832710</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4332-c716c68c52d1e8c1a8965b504c5f5cb6975234aa1222adf6294915afac9e6af53</originalsourceid><addsrcrecordid>eNqNkd-OEyEUxonRuHX1FQxX3s3InwGGxJtN4641VW9qvCSUYSxdZhiBavsyPquMreulkpBDOL_vO5APAIhRjct6va8x5awiVKCaINTUZTNSHx-BxUPjMVggyVElGoKuwLOU9ghhiiV_Cq4wQy2nDC3Az83Owg-r5U1108Ac3eRthtFOVucEp-BPQ4jTzqUBuhHmwuaoxzTYYVuqLeRXF0ZowtjbmKDuOpfLhfYwunQP-xBhZ79bH6bBjhmGHk4pRKezM1DHvIsFT3-slzGUhh7L3Ong9Wz0HDzptU_2xaVeg8-3bzfLd9X601159LoyDaWkMgJzw1vDSIdta7BuJWdbhhrDema2XApGaKM1JoTorudENhIz3WsjLdc9o9fg1dl3iuHbwaasBpeM9b58MhySErilRGD0TxAL2TKMSAHbM2hiSCnaXk3RDTqeFEZqDlHt1ZyVmrNSc4jqd4jqWKQvLzMO28F2f4WX1Arw5gz8cN6e_ttYrd6vyqHIq7PcpWyPD3Id7xUXVDD15eOd2hCyllgKJegvOxK8bA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17985102</pqid></control><display><type>article</type><title>The MICA-A4 triplet repeats polymorphism in the transmembrane region confers additional risk for development of psoriatic arthritis in the Croatian population</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Grubi, Z ; Peri, P ; Eeeuk-Jelici, E ; Unec, R ; Stingl, K ; Urkovi, B ; Kerhin-Brkljaci, V</creator><creatorcontrib>Grubi, Z ; Peri, P ; Eeeuk-Jelici, E ; Unec, R ; Stingl, K ; Urkovi, B ; Kerhin-Brkljaci, V</creatorcontrib><description>Summary
The aim of this study was to investigate possible differences in the frequencies of alleles at the HLA loci and at microsatellite loci within the HLA region among patients suffering from psoriatic arthritis (PsA) and healthy controls. Fifty‐eight Croatian PsA patients (28 male and 30 female) and 157 healthy unrelated controls were typed for HLA alleles (A, B, Cw and DRB1) by the polymerase chain reaction–sequence‐specific primers (PCR‐SSP) method, while microsatellite alleles (D6S265, D6S273, MHC class I chain‐related gene (MICA) and MIB) were analysed by electrophoresis in an ALFexpress sequencer (Pharmacia Biotech, Uppsala, Sweden). The findings from this study were: (1) the frequencies of B*39 and B*57 were significantly increased in PsA patients; (2) differences in the frequencies of B*13 and B*27 were not statistically significant after correction; (3) the B*0702, B*18, and B*38 alleles were decreased in patients only before correction; (4) none of the alleles at other HLA loci tested were associated with PsA in Croatia; (5) polymorphism at D6S265, D6S273, and MIB microsatellites in patients did not show any statistically significant differences when compared to controls; (6) the increase in the MICA‐A4 allele frequency in PsA patients was independent of the B*39 and B*57 alleles.</description><identifier>ISSN: 0960-7420</identifier><identifier>EISSN: 1365-2370</identifier><identifier>DOI: 10.1111/j.1365-2370.2004.00452.x</identifier><identifier>PMID: 15086350</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Age of Onset ; Aged ; Alleles ; Arthritis, Psoriatic - genetics ; Case-Control Studies ; Croatia ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Histocompatibility Antigens Class I - genetics ; HLA-B Antigens - genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Genetic ; Risk ; Trinucleotide Repeats</subject><ispartof>European journal of immunogenetics, 2004-04, Vol.31 (2), p.93-98</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4332-c716c68c52d1e8c1a8965b504c5f5cb6975234aa1222adf6294915afac9e6af53</citedby><cites>FETCH-LOGICAL-c4332-c716c68c52d1e8c1a8965b504c5f5cb6975234aa1222adf6294915afac9e6af53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2370.2004.00452.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2370.2004.00452.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15086350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grubi, Z</creatorcontrib><creatorcontrib>Peri, P</creatorcontrib><creatorcontrib>Eeeuk-Jelici, E</creatorcontrib><creatorcontrib>Unec, R</creatorcontrib><creatorcontrib>Stingl, K</creatorcontrib><creatorcontrib>Urkovi, B</creatorcontrib><creatorcontrib>Kerhin-Brkljaci, V</creatorcontrib><title>The MICA-A4 triplet repeats polymorphism in the transmembrane region confers additional risk for development of psoriatic arthritis in the Croatian population</title><title>European journal of immunogenetics</title><addtitle>Eur J Immunogenet</addtitle><description>Summary
The aim of this study was to investigate possible differences in the frequencies of alleles at the HLA loci and at microsatellite loci within the HLA region among patients suffering from psoriatic arthritis (PsA) and healthy controls. Fifty‐eight Croatian PsA patients (28 male and 30 female) and 157 healthy unrelated controls were typed for HLA alleles (A, B, Cw and DRB1) by the polymerase chain reaction–sequence‐specific primers (PCR‐SSP) method, while microsatellite alleles (D6S265, D6S273, MHC class I chain‐related gene (MICA) and MIB) were analysed by electrophoresis in an ALFexpress sequencer (Pharmacia Biotech, Uppsala, Sweden). The findings from this study were: (1) the frequencies of B*39 and B*57 were significantly increased in PsA patients; (2) differences in the frequencies of B*13 and B*27 were not statistically significant after correction; (3) the B*0702, B*18, and B*38 alleles were decreased in patients only before correction; (4) none of the alleles at other HLA loci tested were associated with PsA in Croatia; (5) polymorphism at D6S265, D6S273, and MIB microsatellites in patients did not show any statistically significant differences when compared to controls; (6) the increase in the MICA‐A4 allele frequency in PsA patients was independent of the B*39 and B*57 alleles.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Alleles</subject><subject>Arthritis, Psoriatic - genetics</subject><subject>Case-Control Studies</subject><subject>Croatia</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Histocompatibility Antigens Class I - genetics</subject><subject>HLA-B Antigens - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Genetic</subject><subject>Risk</subject><subject>Trinucleotide Repeats</subject><issn>0960-7420</issn><issn>1365-2370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd-OEyEUxonRuHX1FQxX3s3InwGGxJtN4641VW9qvCSUYSxdZhiBavsyPquMreulkpBDOL_vO5APAIhRjct6va8x5awiVKCaINTUZTNSHx-BxUPjMVggyVElGoKuwLOU9ghhiiV_Cq4wQy2nDC3Az83Owg-r5U1108Ac3eRthtFOVucEp-BPQ4jTzqUBuhHmwuaoxzTYYVuqLeRXF0ZowtjbmKDuOpfLhfYwunQP-xBhZ79bH6bBjhmGHk4pRKezM1DHvIsFT3-slzGUhh7L3Ong9Wz0HDzptU_2xaVeg8-3bzfLd9X601159LoyDaWkMgJzw1vDSIdta7BuJWdbhhrDema2XApGaKM1JoTorudENhIz3WsjLdc9o9fg1dl3iuHbwaasBpeM9b58MhySErilRGD0TxAL2TKMSAHbM2hiSCnaXk3RDTqeFEZqDlHt1ZyVmrNSc4jqd4jqWKQvLzMO28F2f4WX1Arw5gz8cN6e_ttYrd6vyqHIq7PcpWyPD3Id7xUXVDD15eOd2hCyllgKJegvOxK8bA</recordid><startdate>200404</startdate><enddate>200404</enddate><creator>Grubi, Z</creator><creator>Peri, P</creator><creator>Eeeuk-Jelici, E</creator><creator>Unec, R</creator><creator>Stingl, K</creator><creator>Urkovi, B</creator><creator>Kerhin-Brkljaci, V</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200404</creationdate><title>The MICA-A4 triplet repeats polymorphism in the transmembrane region confers additional risk for development of psoriatic arthritis in the Croatian population</title><author>Grubi, Z ; Peri, P ; Eeeuk-Jelici, E ; Unec, R ; Stingl, K ; Urkovi, B ; Kerhin-Brkljaci, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4332-c716c68c52d1e8c1a8965b504c5f5cb6975234aa1222adf6294915afac9e6af53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Aged</topic><topic>Alleles</topic><topic>Arthritis, Psoriatic - genetics</topic><topic>Case-Control Studies</topic><topic>Croatia</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Histocompatibility Antigens Class I - genetics</topic><topic>HLA-B Antigens - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Genetic</topic><topic>Risk</topic><topic>Trinucleotide Repeats</topic><toplevel>online_resources</toplevel><creatorcontrib>Grubi, Z</creatorcontrib><creatorcontrib>Peri, P</creatorcontrib><creatorcontrib>Eeeuk-Jelici, E</creatorcontrib><creatorcontrib>Unec, R</creatorcontrib><creatorcontrib>Stingl, K</creatorcontrib><creatorcontrib>Urkovi, B</creatorcontrib><creatorcontrib>Kerhin-Brkljaci, V</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunogenetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grubi, Z</au><au>Peri, P</au><au>Eeeuk-Jelici, E</au><au>Unec, R</au><au>Stingl, K</au><au>Urkovi, B</au><au>Kerhin-Brkljaci, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The MICA-A4 triplet repeats polymorphism in the transmembrane region confers additional risk for development of psoriatic arthritis in the Croatian population</atitle><jtitle>European journal of immunogenetics</jtitle><addtitle>Eur J Immunogenet</addtitle><date>2004-04</date><risdate>2004</risdate><volume>31</volume><issue>2</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>0960-7420</issn><eissn>1365-2370</eissn><abstract>Summary
The aim of this study was to investigate possible differences in the frequencies of alleles at the HLA loci and at microsatellite loci within the HLA region among patients suffering from psoriatic arthritis (PsA) and healthy controls. Fifty‐eight Croatian PsA patients (28 male and 30 female) and 157 healthy unrelated controls were typed for HLA alleles (A, B, Cw and DRB1) by the polymerase chain reaction–sequence‐specific primers (PCR‐SSP) method, while microsatellite alleles (D6S265, D6S273, MHC class I chain‐related gene (MICA) and MIB) were analysed by electrophoresis in an ALFexpress sequencer (Pharmacia Biotech, Uppsala, Sweden). The findings from this study were: (1) the frequencies of B*39 and B*57 were significantly increased in PsA patients; (2) differences in the frequencies of B*13 and B*27 were not statistically significant after correction; (3) the B*0702, B*18, and B*38 alleles were decreased in patients only before correction; (4) none of the alleles at other HLA loci tested were associated with PsA in Croatia; (5) polymorphism at D6S265, D6S273, and MIB microsatellites in patients did not show any statistically significant differences when compared to controls; (6) the increase in the MICA‐A4 allele frequency in PsA patients was independent of the B*39 and B*57 alleles.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15086350</pmid><doi>10.1111/j.1365-2370.2004.00452.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0960-7420 |
| ispartof | European journal of immunogenetics, 2004-04, Vol.31 (2), p.93-98 |
| issn | 0960-7420 1365-2370 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71832710 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Age of Onset Aged Alleles Arthritis, Psoriatic - genetics Case-Control Studies Croatia Female Gene Frequency Genetic Predisposition to Disease Histocompatibility Antigens Class I - genetics HLA-B Antigens - genetics Humans Male Middle Aged Polymorphism, Genetic Risk Trinucleotide Repeats |
| title | The MICA-A4 triplet repeats polymorphism in the transmembrane region confers additional risk for development of psoriatic arthritis in the Croatian population |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T22%3A50%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20MICA-A4%20triplet%20repeats%20polymorphism%20in%20the%20transmembrane%20region%20confers%20additional%20risk%20for%20development%20of%20psoriatic%20arthritis%20in%20the%20Croatian%20population&rft.jtitle=European%20journal%20of%20immunogenetics&rft.au=Grubi,%20Z&rft.date=2004-04&rft.volume=31&rft.issue=2&rft.spage=93&rft.epage=98&rft.pages=93-98&rft.issn=0960-7420&rft.eissn=1365-2370&rft_id=info:doi/10.1111/j.1365-2370.2004.00452.x&rft_dat=%3Cproquest_cross%3E71832710%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17985102&rft_id=info:pmid/15086350&rfr_iscdi=true |