Selective vulnerability in the developing central nervous system
Selective patterns of cerebral injury are observed after a variety of insults at different ages during development. Distinct populations of cells demonstrate selective vulnerability during these specific developmental stages, which may account for the observed patterns of injury. We review the evide...
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| Veröffentlicht in: | Pediatric Neurology 2004-04, Vol.30 (4), p.227-235 |
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| container_title | Pediatric Neurology |
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| creator | McQuillen, Patrick S Ferriero, Donna M |
| description | Selective patterns of cerebral injury are observed after a variety of insults at different ages during development. Distinct populations of cells demonstrate selective vulnerability during these specific developmental stages, which may account for the observed patterns of injury. We review the evidence that injury to preoligodendrocytes and subplate neurons contributes to periventricular white matter injury in preterm infants, whereas thalamic neuronal cell vulnerability and neuronal nitric oxide synthase–expressing striatal interneurons resistance result in deep gray nuclei damage in the term infant. The unique roles of particular mechanisms including oxidative stress, glutamatergic neurotransmission, and programmed cell death are discussed in the context of this selective vulnerability. |
| doi_str_mv | 10.1016/j.pediatrneurol.2003.10.001 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0887-8994 |
| ispartof | Pediatric Neurology, 2004-04, Vol.30 (4), p.227-235 |
| issn | 0887-8994 1873-5150 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Brain - pathology Brain Damage, Chronic - pathology Cell Differentiation - physiology Female Gestational Age Humans Infant, Newborn Infant, Premature, Diseases - pathology Medical sciences Neurology Neurons - pathology Oligodendroglia - pathology Pregnancy Risk Factors |
| title | Selective vulnerability in the developing central nervous system |
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