Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice
C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules....
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| Veröffentlicht in: | Journal of investigative dermatology 2004-03, Vol.122 (3), p.670-672 |
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| container_title | Journal of investigative dermatology |
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| creator | Tripp, Christoph H. Chang-Rodriguez, Souyet Stoitzner, Patrizia Holzmann, Sandra Stössel, Hella Douillard, Patrice Saeland, Sem Koch, Franz Elbe-Bürger, Adelheid Romani, Nikolaus |
| description | C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules. We studied the emergence of Langerin expression in LC in epidermal sheets and cell suspensions during ontogeny. Langerin appears later than MHC II expression. Intracellular Langerin expression becomes apparent 2–3 d after birth. Only 10 days after birth all LC co-express Langerin. The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules. |
| doi_str_mv | 10.1111/j.0022-202X.2004.22337.x |
| format | Article |
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Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules. We studied the emergence of Langerin expression in LC in epidermal sheets and cell suspensions during ontogeny. Langerin appears later than MHC II expression. Intracellular Langerin expression becomes apparent 2–3 d after birth. Only 10 days after birth all LC co-express Langerin. The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/j.0022-202X.2004.22337.x</identifier><identifier>PMID: 15086552</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Age Factors ; Animals ; Antigens, Surface - analysis ; Biological and medical sciences ; c-type lectin ; dendritic cells ; Dermatology ; Epidermis - chemistry ; Flow Cytometry ; Histocompatibility Antigens Class II - analysis ; Langerhan ; Langerhans cells ; Langerhans Cells - chemistry ; Lectins, C-Type - analysis ; Mannose-Binding Lectins - analysis ; Medical sciences ; Mice ; Mice, Inbred BALB C ; ontogeny ; postnatal</subject><ispartof>Journal of investigative dermatology, 2004-03, Vol.122 (3), p.670-672</ispartof><rights>2004 The Society for Investigative Dermatology, Inc</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Mar 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-b1ea83e1ad7dd1406685da688f49ac89070510857ab946eac2219487189e879e3</citedby><cites>FETCH-LOGICAL-c545t-b1ea83e1ad7dd1406685da688f49ac89070510857ab946eac2219487189e879e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15849300$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15086552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tripp, Christoph H.</creatorcontrib><creatorcontrib>Chang-Rodriguez, Souyet</creatorcontrib><creatorcontrib>Stoitzner, Patrizia</creatorcontrib><creatorcontrib>Holzmann, Sandra</creatorcontrib><creatorcontrib>Stössel, Hella</creatorcontrib><creatorcontrib>Douillard, Patrice</creatorcontrib><creatorcontrib>Saeland, Sem</creatorcontrib><creatorcontrib>Koch, Franz</creatorcontrib><creatorcontrib>Elbe-Bürger, Adelheid</creatorcontrib><creatorcontrib>Romani, Nikolaus</creatorcontrib><title>Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>C-type lectin receptors help Langerhans cells (LC) to take up and process pathogens. Langerin/CD207 is a mannose-binding C-type lectin that is specifically expressed by LC. It is involved in antigen uptake in an as yet poorly defined way, and it is a major molecular constituent of Birbeck granules. We studied the emergence of Langerin expression in LC in epidermal sheets and cell suspensions during ontogeny. Langerin appears later than MHC II expression. Intracellular Langerin expression becomes apparent 2–3 d after birth. Only 10 days after birth all LC co-express Langerin. The intensity of Langerin expression reaches adult levels by 3 wk after birth. Early Langerin expression appears to correlate at least in part with the physical presence of Birbeck granules.</description><subject>Age Factors</subject><subject>Animals</subject><subject>Antigens, Surface - analysis</subject><subject>Biological and medical sciences</subject><subject>c-type lectin</subject><subject>dendritic cells</subject><subject>Dermatology</subject><subject>Epidermis - chemistry</subject><subject>Flow Cytometry</subject><subject>Histocompatibility Antigens Class II - analysis</subject><subject>Langerhan</subject><subject>Langerhans cells</subject><subject>Langerhans Cells - chemistry</subject><subject>Lectins, C-Type - analysis</subject><subject>Mannose-Binding Lectins - analysis</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>ontogeny</subject><subject>postnatal</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0M9r2zAUwHExWtY0678wzKC72X2SJUu-DNo0_QEpuWzQm1Dk504hkVPJGel_X3kJW-mluujyeY_Hl5CMQkHTu1gWAIzlDNhjwQB4wVhZymL3iYyoYGVOJZdHZPQPnZDTGJcAtOJCfSYnVICqhGAj8mPu--4J_UvWtdnM-CcMzl9MrhnIbLrbBIzRdT5zPut_YzbduAbD2sVBPziLX8hxa1YRzw7_mPy6mf6c3OWz-e395HKWW8FFny8oGlUiNY1sGsqhqpRoTKVUy2tjVQ0SBAUlpFnUvEJjGaM1V5KqGpWssRyT7_u9m9A9bzH2Oh1hcbUyHrtt1EmWlEuV4Ld3cNltg0-3aUahrKCiMiG1RzZ0MQZs9Sa4tQkvmoIeAuulHtrpoZ0eAuu_gfUujX497N8u1tj8HzwUTeD8AEy0ZtUG462Lb5zidQmQ3NXeYcr2x2HQ0Tr0FhsX0Pa66dzH17wCQASWKw</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Tripp, Christoph H.</creator><creator>Chang-Rodriguez, Souyet</creator><creator>Stoitzner, Patrizia</creator><creator>Holzmann, Sandra</creator><creator>Stössel, Hella</creator><creator>Douillard, Patrice</creator><creator>Saeland, Sem</creator><creator>Koch, Franz</creator><creator>Elbe-Bürger, Adelheid</creator><creator>Romani, Nikolaus</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice</title><author>Tripp, Christoph H. ; 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| subjects | Age Factors Animals Antigens, Surface - analysis Biological and medical sciences c-type lectin dendritic cells Dermatology Epidermis - chemistry Flow Cytometry Histocompatibility Antigens Class II - analysis Langerhan Langerhans cells Langerhans Cells - chemistry Lectins, C-Type - analysis Mannose-Binding Lectins - analysis Medical sciences Mice Mice, Inbred BALB C ontogeny postnatal |
| title | Ontogeny of Langerin/CD207 Expression in the Epidermis of Mice |
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