Influence of plasma immunoglobulin level on antibody synthesis
In previous experimental animal studies it has been demonstrated that antibody depletion is not followed by increased antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 pa...
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| Veröffentlicht in: | Blood 2002-07, Vol.100 (1), p.353-355 |
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| creator | Goldammer, Andreas Derfler, Kurt Herkner, Kurt Bradwell, Arthur R. Hörl, Walter H. Haas, Martin |
| description | In previous experimental animal studies it has been demonstrated that antibody depletion is not followed by increased antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 patients treated with immunoadsorption (IA) therapy. Specific and bulk immunoglobulin levels were obtained simultaneously. The mean serum flc concentration increased to the preapheresis value within 1 day and remained unchanged thereafter. Total immunoglobulin G (IgG) and specific antibody concentrations increased to pretreatment values in 88% and 43% of the patients, respectively, and remained below the original values in the others. In conclusion, the lack of increased flc synthesis after IA confirms the absence of a feedback mechanism regulating antibody synthesis. The restoration of serum IgG levels after IA, therefore, does not result from increased antibody synthesis but is probably related to changes of catabolism and immunoglobulin backflow. |
| doi_str_mv | 10.1182/blood-2002-01-0128 |
| format | Article |
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To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 patients treated with immunoadsorption (IA) therapy. Specific and bulk immunoglobulin levels were obtained simultaneously. The mean serum flc concentration increased to the preapheresis value within 1 day and remained unchanged thereafter. Total immunoglobulin G (IgG) and specific antibody concentrations increased to pretreatment values in 88% and 43% of the patients, respectively, and remained below the original values in the others. In conclusion, the lack of increased flc synthesis after IA confirms the absence of a feedback mechanism regulating antibody synthesis. The restoration of serum IgG levels after IA, therefore, does not result from increased antibody synthesis but is probably related to changes of catabolism and immunoglobulin backflow.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2002-01-0128</identifier><identifier>PMID: 12070050</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adult ; Aged ; Antibody Formation - drug effects ; Autoimmune Diseases - blood ; Autoimmune Diseases - drug therapy ; Biological and medical sciences ; Feedback, Physiological - immunology ; Female ; Fundamental and applied biological sciences. 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The restoration of serum IgG levels after IA, therefore, does not result from increased antibody synthesis but is probably related to changes of catabolism and immunoglobulin backflow.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibody Formation - drug effects</subject><subject>Autoimmune Diseases - blood</subject><subject>Autoimmune Diseases - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Feedback, Physiological - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Immunoglobulin kappa-Chains - blood</subject><subject>Immunoglobulins - blood</subject><subject>Immunoglobulins - pharmacology</subject><subject>Immunopathology</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunotherapy (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7vrxBzxIL3qrziRt04IIIn6B4EXPIV_VSJqsTbuw_96uu7A3YWBgeN6X4SHkDOEKsabXysdocgpAc8BpaL1H5ljSOp9OsE_mAFDlRcNxRo5S-gbAgtHykMyQAgcoYU5uX0LrRxu0zWKbLbxMncxc140hfvqoRu9C5u3S-iyGTIbBqWhWWVqF4csml07IQSt9sqfbfUw-Hh_e75_z17enl_u711wXtBpy1RqoGmzaWtGCMaVoZSoKNTcKgStrmIaqbJhFqdE0XDeMalSSm4IiKM2OyeWmd9HHn9GmQXQuaeu9DDaOSXCsGRbAJ5BuQN3HlHrbikXvOtmvBIJYWxN_1sTamgAUa2tT6HzbPqrOml1kq2kCLraATFr6tpdBu7TjGC8pLXDibjacnVwsne1F0m4t17je6kGY6P774xcLdIpL</recordid><startdate>20020701</startdate><enddate>20020701</enddate><creator>Goldammer, Andreas</creator><creator>Derfler, Kurt</creator><creator>Herkner, Kurt</creator><creator>Bradwell, Arthur R.</creator><creator>Hörl, Walter H.</creator><creator>Haas, Martin</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020701</creationdate><title>Influence of plasma immunoglobulin level on antibody synthesis</title><author>Goldammer, Andreas ; Derfler, Kurt ; Herkner, Kurt ; Bradwell, Arthur R. ; Hörl, Walter H. ; Haas, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-bfd06919f8b2433bb26d62087db107bed3c06593e1ac1d97c932c1ba7d4210bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibody Formation - drug effects</topic><topic>Autoimmune Diseases - blood</topic><topic>Autoimmune Diseases - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Feedback, Physiological - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Immunoglobulin kappa-Chains - blood</topic><topic>Immunoglobulins - blood</topic><topic>Immunoglobulins - pharmacology</topic><topic>Immunopathology</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunotherapy (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Goldammer, Andreas</creatorcontrib><creatorcontrib>Derfler, Kurt</creatorcontrib><creatorcontrib>Herkner, Kurt</creatorcontrib><creatorcontrib>Bradwell, Arthur R.</creatorcontrib><creatorcontrib>Hörl, Walter H.</creatorcontrib><creatorcontrib>Haas, Martin</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Goldammer, Andreas</au><au>Derfler, Kurt</au><au>Herkner, Kurt</au><au>Bradwell, Arthur R.</au><au>Hörl, Walter H.</au><au>Haas, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of plasma immunoglobulin level on antibody synthesis</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2002-07-01</date><risdate>2002</risdate><volume>100</volume><issue>1</issue><spage>353</spage><epage>355</epage><pages>353-355</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>In previous experimental animal studies it has been demonstrated that antibody depletion is not followed by increased antibody synthesis. To assess whether these results are conferrable to antibody-depleted humans, we measured free light chains (flcs) as markers of current antibody synthesis in 8 patients treated with immunoadsorption (IA) therapy. Specific and bulk immunoglobulin levels were obtained simultaneously. The mean serum flc concentration increased to the preapheresis value within 1 day and remained unchanged thereafter. Total immunoglobulin G (IgG) and specific antibody concentrations increased to pretreatment values in 88% and 43% of the patients, respectively, and remained below the original values in the others. In conclusion, the lack of increased flc synthesis after IA confirms the absence of a feedback mechanism regulating antibody synthesis. The restoration of serum IgG levels after IA, therefore, does not result from increased antibody synthesis but is probably related to changes of catabolism and immunoglobulin backflow.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>12070050</pmid><doi>10.1182/blood-2002-01-0128</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antibody Formation - drug effects Autoimmune Diseases - blood Autoimmune Diseases - drug therapy Biological and medical sciences Feedback, Physiological - immunology Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunobiology Immunoglobulin kappa-Chains - blood Immunoglobulins - blood Immunoglobulins - pharmacology Immunopathology Immunosuppressive Agents - administration & dosage Immunotherapy (general aspects) Male Medical sciences Middle Aged Modulation of the immune response (stimulation, suppression) |
| title | Influence of plasma immunoglobulin level on antibody synthesis |
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